SLC26A5 / Prestin antibody

Principal name

SLC26A5 / Prestin antibody

Alternative names for SLC26A5 / Prestin antibody

PRES, Solute carrier family 26 member 5

SwissProt ID

P58743 (Human), Q99NH7 (Mouse), Q9EPH0 (Rat)

Gene ID

375611 (SLC26A5)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of SLC26A5 / Prestin antibody

SLC26A5 (Solute carrier family 26, member 5) is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. It acts as a motor protein that converts auditory stimuli to length changes in outer hair cells. It is a bidirectional voltage-to-force converter which uses cytoplasmic anions as extrinsic voltage sensors. The anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. This translocation triggers conformational changes in the protein that alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). It acts as an incomplete transporter since it moves anions across the membrane, but does not allow the anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the anion-binding site. Mutations in SLC26A5 have been associated with non-syndromic hearing loss.

General readings

Chambard,J.M. (2005) Pflugers Arch. 450 (1), 34-44

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC26A5 / Prestin antibody

WB Suggested Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC26A5 / Prestin antibody

Detection limit for recombinant GST tagged SLC26A5 is approximately 1ng/ml as a capture antibody. Mouse IgG2a 1F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SLC26A5 / Prestin antibody

SLC26A5 / Prestin Goat Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

SLC26A5 / Prestin antibody

Human Lung; SLC26A5 antibody - middle region (ARP44176_T100) in Human Lung cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

SLC26A5 / Prestin antibody

Western Blot: SLC26A5 Antibody [NBP1-59791] - This Anti-SLC26A5 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 2.5ug/ml. Rabbit Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC26A5 / Prestin

SLC26A5 / Prestin Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SLC26A5 overexpression lysate

SLC26A5 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

7 Item(s)

per page
  • LinkedIn