SLC29A2 / ENT2 antibody

Principal name

SLC29A2 / ENT2 antibody

Alternative names for SLC29A2 / ENT2 antibody

DER12, HNP36, Solute carrier family 29 member 2, Equilibrative nucleoside transporter 2, Delayed-early response protein 12, Hydrophobic nucleolar protein 36 kDa, 36 kDa nucleolar protein HNP36

SwissProt ID

O54699 (Rat), Q14542 (Human), Q61672 (Mouse)

Gene ID

3177 (SLC29A2), 100911721 (LOC100911721), 13340 (Slc29a2), 65194

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Rb (Rabbit), Rt (Rat), Ms (Mouse), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SLC29A2 / ENT2 antibody

Nucleosides play other important roles beyond their nucleic acid synthesis building block role. For example, they are involved in energy metabolism; they serve as ligands of purinergic receptors and act as influential sigling molecules. Being hydrophilic, nucleosides cannot simply diffuse across the plasma membrane in order to exert their various functions, but rather need to be physically transported via nucleoside transporters.Two different transporter families are responsible for transporting nucleosides across the plasma membrane: The Concentrative Nucleoside Transporter proteins (CNT, SLC28 family), which consist of three members, CNT1-3, and act as +-dependent symporters. The Equilibrative Nucleoside Transporter proteins ENT1-4 (ENT, SLC29 family), which mediate a +-independent facilitated diffusion. Therefore, ENTs act as bidirectiol carriers, responsible for the influx and efflux of substrates.Structurally, ENT transporters have eleven transmembrane domains with an intracellular N-termil and an extracellular C-termil.The best characterized ENT transporters are ENT1 and ENT2, which although display a broader range of substrate selectivity, have lower affinities for nucleosides compared to concentrative transporters. They are ubiquitously expressed, for example ENT1 is expressed in erythrocytes, vascular endothelium, placenta, brain, heart, liver and colon. ENT2 displays more or less the same expression pattern but in addition, is strongly expressed in skeletal muscle. ENT3 is a lysosomal pH-dependent transporter capable of transporting adenine, and ENT4 also transports adenine at acidic pH. Both ENT3 and ENT4 are broadly expressed. The former displays high expression in the placenta and the latter in the heart.As mentioned above, nucleosides have a variety of cellular/physiological functions suggesting that transporters responsible for their trafficking may also have functiol attributes. Indeed, ENT1 plays a role in proliferation and therefore is responsible for the constitutive trafficking of nucleosides.There is no evidence that nucleoside transporters are directly involved in pathophysiologies, but they are clinically significant. For example, nucleoside transporters are responsible for the cellular uptake of a number of nucleoside-derived anticancer drugs.

General readings

Owen,R.P., (2006) Drug Metab. Dispos. 34 (1), 12-15

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC29A2 / ENT2 antibody

  Rabbit Polyclonal Anti-SLC29A2 Antibody  
WB Suggested Anti-SLC29A2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC29A2 / ENT2 antibody

Hum. Fetal Liver; Host:Rabbit. Target Name:SLC29A2. Sample Tissue:Human Fetal Liver. Antibody Dilution: 1.0ug/ml.; SLC29A2 antibody - C-terminal region (ARP43823_P050) in Hum. Fetal Liver cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SLC29A2 / ENT2 antibody

  Rabbit polyclonal Anti-Equilibrative Nucleoside Transporter 2 (ENT2)  
Western blot analysis of rat heart (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates: 1-2. Anti-Equilibrative Nucleoside Transporter 2 (ENT2) antibody , (1:200). 3-4. Anti-Equilibrative Nucleoside Transporter 2 (ENT2) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC29A2 / ENT2 antibody

  Rabbit Polyclonal Anti-SLC29A2 Antibody  
WB Suggested Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 Rabbit IgG Purified Hu, Rb P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC29A2 / ENT2 antibody

  Rabbit Polyclonal Anti-SLC29A2 Antibody  
Western blot analysis of SLC29A2 in human bladder tissue lysate with SLC29A2 antibody at 1 ug/mL. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC29A2 / ENT2 antibody

Immunofluorescence of purified MaxPab antibody to SLC29A2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

SLC29A2 / ENT2 antibody

Immunofluorescence of purified MaxPab antibody to SLC29A2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

SLC29A2 / ENT2 antibody

Human kidney; SLC29A2 antibody - N-terminal region (ARP43822_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Hu P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

SLC29A2 - human gene knockout kit via CRISPR

SLC29A2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC29A2 - human gene knockout kit via CRISPR

SLC29A2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC29A2 - human gene knockout kit via CRISPR

SLC29A2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC29A2 - human gene knockout kit via CRISPR

SLC29A2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc29a2 - mouse gene knockout kit via CRISPR

Slc29a2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc29a2 - mouse gene knockout kit via CRISPR

Slc29a2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc29a2 - mouse gene knockout kit via CRISPR

Slc29a2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc29a2 - mouse gene knockout kit via CRISPR

Slc29a2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC29A2 / ENT2

  Recombinant protein of human solute carrier family 29 (nucleoside transporters), member 2 (SLC29A2)  
SLC29A2 / ENT2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SLC29A2 / ENT2

SLC29A2 / ENT2 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SLC29A2 293T Cell Transient Overexpression Lysate(Denatured)

SLC29A2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC29A2 (mGFP-tagged) - Human solute carrier family 29 (nucleoside transporters), member 2 (SLC29A2), 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC29A2 (mGFP-tagged) - Human solute carrier family 29 (nucleoside transporters), member 2 (SLC29A2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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