SLC35E4 antibody

Principal name

SLC35E4 antibody

Alternative names for SLC35E4 antibody

Solute carrier family 35 member E4

SwissProt ID

Q5RKL7 (Rat), Q6ICL7 (Human), Q8K3D6 (Mouse)

Gene ID

339665 (SLC35E4), 103710 (Slc35e4)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Mky (Monkey)

Available hosts

Rabbit

Available applications

Dot blot (Dot), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of SLC35E4 antibody

In Alzheimer’s disease (AD) a progressive neurodegeneration and cognitive decline occurs during the course of the disease and amylloid beta-peptide (Abeta) is believed to play a central role for the molecular pathogenesis of AD. The gamma-Secretase is a key enzyme involved in the processing of the beta-amyloid precursor protein into Abeta. Abeta accumulates in brain and forms plaques in AD brains. One of the mechanism behind neurodegenration in AD is apoptosis due to preservation of gamma secretase activity. Several proteins (presenilin1, presenilin 2, nicastrin, Aph-1 and Pen-2) interact with gamma secretase complex during apoptosis in neuronal cells to make active gamma secretase complexes in apoptotic cells. The fragments corresponding to the PS1 N-terminal fragment and the caspase-cleaved PS1 C-terminal fragment (PS1-caspCTF) were found to form active gamma-secretase complexes when co-expressed in presenilin (PS) knockout cells (1). Mutations in presenilin 1 (PS1) lead to dominant inheritance of early-onset familial Alzheimer’s disease (FAD). These mutations are known to alter the gamma-secretase cleavage of the amyloid precursor protein (APP), resulting in increased ratio of Abeta42/Abeta40 and accelerated amyloid plaque pathology and altered intracellular Ca(2+) homeostasis involving endoplasmic reticulum Ca(2+) stores (2, 3). It is suggested that Presenilin binds to phospholipase D1 through its loop region thereby recruiting golgi/transgolgi network that perturbs gamma secretase activity and Abeta formation.
Numerous mutations in the presenilins are known to cause early-onset familial Alzheimer’s disease (FAD). These mutations are known to alter the gamma-secretase cleavage of the amyloid precursor protein (APP), resulting in increased ratio of Abeta42/Abeta40 and accelerated amyloid plaque pathology in transgenic mouse models. Presenelin 1is a 467 amino acid membrane bound protein with 8 putative TMD. It is believed to be the catalytic domain of gamma secretase complex that catalyzes the intramembrane cleavage of integral membraneproteins such as Notch receptors and beta amyloid precursor protein. Other functions include intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Some regulatory proteins associated with Resenelin are Nicastrin, NTF, CTF, APH1/2and PEN2. It also interacts with other proteins such as Notch1, cadherin 1, plakophilin 4, dock 3, catenin, HERPUD1, FLNA and FLNB.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC35E4 control peptide

SLC35E4
0.1 mg / €250.00
  Acris Antibodies GmbH

SLC35E4 (172-195) antibody

Western Blot using Slc35E4 antibody (AP10325PU-N at 1/500 dilution) Rabbit IgG Aff - Purified Hu, Mky, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SLC35E4 antibody

SLC35E4 Rabbit Ms, Rt Dot, E, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC35E4

SLC35E4 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SLC35E4 overexpression lysate

SLC35E4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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