SLC47A1 antibody

Principal name

SLC47A1 antibody

Alternative names for SLC47A1 antibody

MATE1, Multidrug and toxin extrusion protein 1, MATE-1, Solute carrier family 47 member 1

SwissProt ID

A7KAU2 (Rabit), Q5I0E9 (Rat), Q8K0H1 (Mouse), Q96FL8 (Human)

Gene ID

55244 (SLC47A1)

Available reactivities

Hu (Human)

Available hosts

Goat, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of SLC47A1 antibody

Transporters are expressed in a wide variety of tissues where they perform the critical function of enabling anionic and cationic chemicals of exogenous and endogenous origin to cross otherwise impermeable cell membranes. The multidrug and toxin extrusion (MATE) transporters mediate cellular efflux of a variety of organic cations, including many drugs, and are involved in excretion of toxic electrolytes through urine and bile. Members of the MATE family share homology with the bacterial MATE protein family, which is responsible for drug resistance. MATE1 (multidrug and toxin extrusion protein 1), also known as SLC47A1, is a 570 amino acid multi-pass membrane protein that predominantly localizes to the plasma membrane but is also found in intracellular organelles. Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney, MATE1 is responsible for the secretion of cationic drugs across the brush border membranes. MATE1 exists as three isoforms, which are produced by alternative splicing events.

General readings

1. Chen Y, Zhang S, Sorani M, Giacomini KM.
Transport of paraquat by human organic cation transporters and multidrug and toxic. compound extrusion family. J. Pharmacol. Exp. Ther. 2007 Aug 322 (2): 695-700.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC47A1 antibody

TA305903 (0.1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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