SLC4A4 / NBCE1 antibody

Principal name

SLC4A4 / NBCE1 antibody

Alternative names for SLC4A4 / NBCE1 antibody

Sodium bicarbonate cotransporter 1, NBC1, NBC, Solute carrier family 4 member 4, Electrogenic sodium bicarbonate cotransporter 1, Na(+)/HCO3(-) cotransporter

SwissProt ID

O88343 (Mouse), Q4U116 (Pig), Q9GL77 (Bovin), Q9JI66 (Rat), Q9XSZ4 (Rabit), Q9Y6R1 (Human)

Gene ID

8671 (SLC4A4), 84484 (Slc4a4)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of SLC4A4 / NBCE1 antibody

SLC4 membrane transporter proteins play important roles in kidney acidâ??base regulation through their transport of bicarbote (or carbote), ?+, Cl-, and (possibly NH4+)1. These transporters differ in their substrate (+?, Cl-) dependence, charge transport stoichiometry, cell-type and developmental expression, functiol regulation, and proteinâ??protein interactions. In mammals, SLC4 proteins are encoded by 10 different genes that share protein sequence homology and are grouped according to their functiol properties.In humans, the electrogenic sodium bicarbote cotransporter NBCe-1 is encoded by the SLC4A4 gene. NBCe1-A has a large N-termil cytoplasmic region, a lipid embedded transmembrane region, and a C-termil cytoplasmic tail. The N-termil cytoplasmic region is tightly folded and is predicted to form a domain structure, unlike the freely aqueous accessible C-termil cytoplasmic tail. NBCe1-A is composed of either 10 or 14 transmembrane domains. Based on the 10 transmembrane topology, a large extracellular loop (EL) is present between TM3 and TM4 and contains two glycosylated sites. The oligomeric state of the cotransporter is dimeric and each monomeric subunit has independent transport activity.Mutations in NBCe1 cause autosomal recessive proximal rel tubular acidosis (pRTA). Patients with NBCe1 mutations have severe pRTA, growth and mental retardation, basal ganglia calcification, cataracts, corneal opacities (band keratopathy), glaucoma, elevated serum amylase and lipase, and defects in the emel consistent with amelogenesis imperfect. Mice with loss of NBCe1 have a more severe phenotype with marked volume deletion and decreased survival.

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  2. Highly Validated (2)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC4A4 / NBCE1 antibody

Western blot analysis of rat brain lysate: 1. Anti-NBCe1 (extracellular) antibody , (1:200). 2. Anti-NBCe1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

Western blot analysis of extracts of various cell lines, using SLC4A4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

Predicted cell location: Cytoplasm . Positive control: Human brain and colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using SLC4A4 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

Predicted cell location: Cytoplasm . Positive control: Human brain and colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using SLC4A4 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

SLC4A4 / NBCE1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SLC4A4 / NBCE1 antibody

Detection limit for recombinant GST tagged SLC4A4 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 1G2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SLC4A4 / NBCE1 antibody

SLC4A4 / NBCE1 Rabbit Hu, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC4A4 / NBCE1 (Isoform 2) (1-424, His-tag)

NBC1, 1-424 aa human, His-tagged, recombinant, E.coli: 15% SDS-PAGE (3 µg) Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

SLC4A4 / NBCE1 (Isoform 2) (1-424, His-tag)

NBC1, 1-424 aa human, His-tagged, recombinant, E.coli: 15% SDS-PAGE (3 µg) Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

SLC4A4 / NBCE1

SLC4A4 / NBCE1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SLC4A4 / NBCE1

SLC4A4 / NBCE1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

SLC4A4 / NBCE1

SLC4A4 / NBCE1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SLC4A4 / NBCE1

SLC4A4 / NBCE1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

SLC4A4 / NBCE1

SDS-Page: SLC4A4 Protein [NBC1-22950] - NBC1, 51.5 kDa (460aa) with a purity of 90% by SDS - PAGE Protein
0.1 mg / €380.00
  Novus Biologicals Inc.

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