SLC4A4 / NBCE1 antibody

Principal name

SLC4A4 / NBCE1 antibody

Alternative names for SLC4A4 / NBCE1 antibody

Sodium bicarbonate cotransporter 1, NBC1, NBC, Solute carrier family 4 member 4, Electrogenic sodium bicarbonate cotransporter 1, Na(+)/HCO3(-) cotransporter

SwissProt ID

O88343 (Mouse), Q4U116 (Pig), Q9GL77 (Bovin), Q9JI66 (Rat), Q9XSZ4 (Rabit), Q9Y6R1 (Human)

Gene ID

8671 (SLC4A4), 84484 (Slc4a4), 54403

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SLC4A4 / NBCE1 antibody

SLC4 membrane transporter proteins play important roles in kidney acidâ??base regulation through their transport of bicarbote (or carbote), ?+, Cl-, and (possibly NH4+)1. These transporters differ in their substrate (+?, Cl-) dependence, charge transport stoichiometry, cell-type and developmental expression, functiol regulation, and proteinâ??protein interactions. In mammals, SLC4 proteins are encoded by 10 different genes that share protein sequence homology and are grouped according to their functiol properties.In humans, the electrogenic sodium bicarbote cotransporter NBCe-1 is encoded by the SLC4A4 gene. NBCe1-A has a large N-termil cytoplasmic region, a lipid embedded transmembrane region, and a C-termil cytoplasmic tail. The N-termil cytoplasmic region is tightly folded and is predicted to form a domain structure, unlike the freely aqueous accessible C-termil cytoplasmic tail. NBCe1-A is composed of either 10 or 14 transmembrane domains. Based on the 10 transmembrane topology, a large extracellular loop (EL) is present between TM3 and TM4 and contains two glycosylated sites. The oligomeric state of the cotransporter is dimeric and each monomeric subunit has independent transport activity.Mutations in NBCe1 cause autosomal recessive proximal rel tubular acidosis (pRTA). Patients with NBCe1 mutations have severe pRTA, growth and mental retardation, basal ganglia calcification, cataracts, corneal opacities (band keratopathy), glaucoma, elevated serum amylase and lipase, and defects in the emel consistent with amelogenesis imperfect. Mice with loss of NBCe1 have a more severe phenotype with marked volume deletion and decreased survival.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC4A4 / NBCE1 antibody

  Rabbit polyclonal Anti-NBCe1 (extracellular)  
Western blot analysis of rat brain lysate: 1. Anti-NBCe1 (extracellular) antibody , (1:200). 2. Anti-NBCe1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

  Rabbit anti-SLC4A4 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using SLC4A4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

  Anti-SLC4A4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human brain and colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using SLC4A4 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC4A4 / NBCE1 antibody

  Anti-SLC4A4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human brain and colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using SLC4A4 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SLC4A4 - human gene knockout kit via CRISPR

SLC4A4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC4A4 - human gene knockout kit via CRISPR

SLC4A4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC4A4 - human gene knockout kit via CRISPR

SLC4A4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC4A4 - human gene knockout kit via CRISPR

SLC4A4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc4a4 - mouse gene knockout kit via CRISPR

Slc4a4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc4a4 - mouse gene knockout kit via CRISPR

Slc4a4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc4a4 - mouse gene knockout kit via CRISPR

Slc4a4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc4a4 - mouse gene knockout kit via CRISPR

Slc4a4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC4A4 / NBCE1 (Isoform 2) (1-424, His-tag)

NBC1, 1-424 aa human, His-tagged, recombinant, E.coli: 15% SDS-PAGE (3 µg) Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

SLC4A4 / NBCE1 (Isoform 2) (1-424, His-tag)

NBC1, 1-424 aa human, His-tagged, recombinant, E.coli: 15% SDS-PAGE (3 µg) Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC4A4 (mGFP-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC4A4 (mGFP-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC4A4 (mGFP-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC4A4 (mGFP-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC4A4 (Myc-DDK-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC4A4 (Myc-DDK-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,950.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC4A4 (Myc-DDK-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC4A4 (Myc-DDK-tagged)-Human solute carrier family 4, sodium bicarbonate cotransporter, member 4 (SLC4A4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,890.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc4a4 (GFP-tagged) - Mouse solute carrier family 4 (anion exchanger), member 4 (Slc4a4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc4a4 (GFP-tagged) - Mouse solute carrier family 4 (anion exchanger), member 4 (Slc4a4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,890.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc4a4 (GFP-tagged) - Mouse solute carrier family 4 (anion exchanger), member 4 (Slc4a4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc4a4 (GFP-tagged) - Mouse solute carrier family 4 (anion exchanger), member 4 (Slc4a4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,900.00
  OriGene Technologies, Inc.

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