SLC6A4 / SERT antibody

Principal name

SLC6A4 / SERT antibody

Alternative names for SLC6A4 / SERT antibody

5HT transporter, 5HTT, HTT, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4

SwissProt ID

O35899 (Cavpo), P31645 (Human), P31652 (Rat), P51905 (Drome), Q60857 (Mouse), Q9XT49 (Bovin)

Gene ID

6532 (SLC6A4), 25553 (Slc6a4)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of SLC6A4 / SERT antibody

Many physiological, endocrine and behavioral functions are determined and regulated by monoamine sigling. Many brain disorders such as depression, drug abuse, schizophrenia, attention deficit hyperactivity disorder (ADHD) are caused by the malfunction of monoaminergic transmission. The intensity of monoaminergic sigling is determined by the availability of the monoamine, which is in turn determined in part by its uptake from the extracellular milieu via monoamine transporters. These transporters include DAT, SERT, and NET, responsible for uptaking dopamine, serotonin (5-HT) and noradreline respectively, and recycling them back for release. DAT, SERT and NET are members of the +/Cl dependent membrane transporter family which also includes other members. These transporters consist of 12 transmembrane domains and intracellular N- and C-termini. Like its counterparts, SERT’s intracellular N- and C-termil domains are also subject to phosphorylation and protein-protein interactions important for modulating its activity and localization. SERTs are evidently expressed in serotonergic neurons, and are also expressed in various peripheral tissues including specialized cells of the gut, placenta, lung, blood lymphocytes and platelets. SERT knockout mice are viable and as a consequence exhibit increased extracellular levels of 5-HT and significantly decreased levels of brain tissue 5-HT due to deficient recycling and re-accumulation of serotonin by SERT. Phenotypes displayed by SERT knockout mice include stress sensitivity, obesity and various behavioral changes

General readings

Voeller KK. Attention-deficit hyperactivity disorder (ADHD). J Child Neurol. 2004 Oct;19(10):798-814.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC6A4 / SERT antibody

  Rabbit Polyclonal Anti-Serotonin Transporter (SERT) (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1-2. Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:200). 3-4. Anti-Serotonin Transporter (SERT) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC6A4 / SERT (605-618) antibody

Staining of Mouse Small Intestine lysate (35µg protein in RIPA buffer) using SLC6A4 Antibody Cat.-No AP31853PU-N at 0.5 µg/ml. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SLC6A4 / SERT antibody

  Goat Polyclonal Antibody against SLC6A4  
TA303021 staining (1µg/ml) of Human Duodenum lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC6A4 / SERT antibody

  Rabbit Polyclonal Anti-SLC6A4 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (SLC6A4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC6A4 / SERT antibody

SLC6A4 / SERT Mouse IgG1 2D7/3 Aff - Purified Ms, Rt C
0.1 mg / €930.00
  Acris Antibodies GmbH

SLC6A4 / SERT antibody

SLC6A4 / SERT Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SLC6A4 / SERT antibody

SLC6A4 MaxPab rabbit polyclonal antibody. Western Blot analysis of SLC6A4 expression in mouse lung. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SLC6A4 / SERT antibody

Detection limit for recombinant GST tagged SLC6A4 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 2A9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SLC6A4 / SERT antibody

SLC6A4 polyclonal antibody ( Cat # PAB6784 ) staining ( 1 µg/ml ) of human duodenum lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

SLC6A4 / SERT antibody

SLC6A4 / SERT Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

SLC6A4 / SERT antibody

SLC6A4 / SERT Rabbit IgG Aff - Purified Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

SLC6A4 / SERT (579-599) antibody

Staining with 5-HT (Serotonin) Transporter Antibody 24330 Rabbit Serum Hu, Mky, Ms, Rt C, ICC/IF, WB
0.1 ml / €520.00
  ImmunoStar Inc.

SLC6A4 / SERT Control Peptide

SLC6A4 / SERT Purified
25 µg / €190.00
  ImmunoStar Inc.

SLC6A4 / SERT antibody

SLC6A4 / SERT Mouse IgG1 17-7A4 Purified Ms, Rt P
0.1 mg / €360.00
  Neuromics Antibodies

SLC6A4 / SERT antibody

SLC6A4 / SERT Rabbit Serum Rt C, ICC/IF, WB
0.1 ml / €440.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

SLC6A4 - human gene knockout kit via CRISPR

SLC6A4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC6A4 - human gene knockout kit via CRISPR

SLC6A4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC6A4 - human gene knockout kit via CRISPR

SLC6A4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC6A4 - human gene knockout kit via CRISPR

SLC6A4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC6A4 / SERT

  Purified recombinant protein of Homo sapiens solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4)  
SLC6A4 / SERT Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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