SLC6A4 / SERT antibody
Principal name
SLC6A4 / SERT antibody
Alternative names for SLC6A4 / SERT antibody
5HT transporter, 5HTT, HTT, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4
SwissProt ID
O35899 (Cavpo), P31645 (Human), P31652 (Rat), P51905 (Drome), Q60857 (Mouse), Q9XT49 (Bovin)
Ncbi ID
NP_001036, NP_001036.1, 9606, NP_037166.2, NM_013034, NM_001045
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P)
Background of SLC6A4 / SERT antibody
Many physiological, endocrine and behavioral functions are determined and regulated by monoamine sigling. Many brain disorders such as depression, drug abuse, schizophrenia, attention deficit hyperactivity disorder (ADHD) are caused by the malfunction of monoaminergic transmission. The intensity of monoaminergic sigling is determined by the availability of the monoamine, which is in turn determined in part by its uptake from the extracellular milieu via monoamine transporters. These transporters include DAT, SERT, and NET, responsible for uptaking dopamine, serotonin (5-HT) and noradreline respectively, and recycling them back for release. DAT, SERT and NET are members of the +/Cl dependent membrane transporter family which also includes other members. These transporters consist of 12 transmembrane domains and intracellular N- and C-termini. Like its counterparts, SERT’s intracellular N- and C-termil domains are also subject to phosphorylation and protein-protein interactions important for modulating its activity and localization. SERTs are evidently expressed in serotonergic neurons, and are also expressed in various peripheral tissues including specialized cells of the gut, placenta, lung, blood lymphocytes and platelets. SERT knockout mice are viable and as a consequence exhibit increased extracellular levels of 5-HT and significantly decreased levels of brain tissue 5-HT due to deficient recycling and re-accumulation of serotonin by SERT. Phenotypes displayed by SERT knockout mice include stress sensitivity, obesity and various behavioral changes
General readings
Voeller KK. Attention-deficit hyperactivity disorder (ADHD). J Child Neurol. 2004 Oct;19(10):798-814.










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- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA328879 | SLC6A4 / SERT antibody |
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Rabbit Polyclonal Anti-Serotonin Transporter (SERT) (extracellular) | |||||||
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Rabbit | Purified | Hu, Ms, Rt | WB |
0.2 ml /
€622.00
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OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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AP31853PU-N | SLC6A4 / SERT (605-618) antibody |
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Goat | Aff - Purified | Bov, Hu, Ms, Rt | E, F, ICC/IF, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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Acris recommends this product for Western blotting. |
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TA303021 | SLC6A4 / SERT antibody |
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Goat Polyclonal Antibody against SLC6A4 | |||||||
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Goat | Aff - Purified | Hu | WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA350956 | SLC6A4 / SERT antibody |
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Rabbit Polyclonal Anti-SLC6A4 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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BM711 | SLC6A4 / SERT antibody |
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Mouse | IgG1 | 2D7/3 | Aff - Purified | Ms, Rt | C |
0.1 mg /
€960.00
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Acris Antibodies GmbH | |||||||
24330 | SLC6A4 / SERT (579-599) antibody |
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Rabbit | Serum | Hu, Mky, Ms, Rt | C, ICC/IF, WB |
0.1 ml /
€520.00
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ImmunoStar Inc. | |||||||
24332 | SLC6A4 / SERT Control Peptide |
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Purified |
25 µg /
€190.00
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ImmunoStar Inc. | |||||||
RA24330-100 | SLC6A4 / SERT antibody |
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Rabbit | Serum | Rt | C, ICC/IF, WB |
0.1 ml /
€490.00
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Neuromics Antibodies |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN210187 | SLC6A4 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN210187BN | SLC6A4 - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN210187LP | SLC6A4 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN210187RB | SLC6A4 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP310187 | SLC6A4 / SERT |
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Purified recombinant protein of Homo sapiens solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
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OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC210187L2V | Lenti ORF particles, SLC6A4 (mGFP-tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC210187L1V | Lenti ORF particles, SLC6A4 (Myc-DDK tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) , 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
Catalog No. | ||
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RR213933L2V | Lenti ORF particles, Slc6a4 (GFP-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4), 200 uL, >10^7 TU/mL |
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200 µl /
€1,329.00
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OriGene Technologies, Inc. | ||
RR213933L1V | Lenti ORF particles, Slc6a4 (Myc-DDK-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4), 200 uL, >10^7 TU/mL |
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200 µl /
€1,192.00
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OriGene Technologies, Inc. | ||