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Home » Target » SLC6A4 / SERT antibody

SLC6A4 / SERT antibody

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Principal name

SLC6A4 / SERT antibody

Alternative names for SLC6A4 / SERT antibody

5HT transporter, 5HTT, HTT, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4

SwissProt ID

O35899 (Cavpo), P31645 (Human), P31652 (Rat), P51905 (Drome), Q60857 (Mouse), Q9XT49 (Bovin)

Gene ID

6532 (SLC6A4), 25553 (Slc6a4)

Ncbi ID

NP_001036, NP_001036.1, 9606, NP_037166.2, NM_013034, NM_001045

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of SLC6A4 / SERT antibody

Many physiological, endocrine and behavioral functions are determined and regulated by monoamine sigling. Many brain disorders such as depression, drug abuse, schizophrenia, attention deficit hyperactivity disorder (ADHD) are caused by the malfunction of monoaminergic transmission. The intensity of monoaminergic sigling is determined by the availability of the monoamine, which is in turn determined in part by its uptake from the extracellular milieu via monoamine transporters. These transporters include DAT, SERT, and NET, responsible for uptaking dopamine, serotonin (5-HT) and noradreline respectively, and recycling them back for release. DAT, SERT and NET are members of the +/Cl dependent membrane transporter family which also includes other members. These transporters consist of 12 transmembrane domains and intracellular N- and C-termini. Like its counterparts, SERT’s intracellular N- and C-termil domains are also subject to phosphorylation and protein-protein interactions important for modulating its activity and localization. SERTs are evidently expressed in serotonergic neurons, and are also expressed in various peripheral tissues including specialized cells of the gut, placenta, lung, blood lymphocytes and platelets. SERT knockout mice are viable and as a consequence exhibit increased extracellular levels of 5-HT and significantly decreased levels of brain tissue 5-HT due to deficient recycling and re-accumulation of serotonin by SERT. Phenotypes displayed by SERT knockout mice include stress sensitivity, obesity and various behavioral changes

General readings

Voeller KK. Attention-deficit hyperactivity disorder (ADHD). J Child Neurol. 2004 Oct;19(10):798-814.

24330 - SLC6A4 / SERT
Staining with 5-HT (Serotonin) Transporter Antibody 24330
H00006532-M06 - SLC6A4 / SERT
Detection limit for recombinant GST tagged SLC6A4 is approximately 0.3ng/ml as a capture antibody.
PAB6784 - SLC6A4 / SERT
SLC6A4 polyclonal antibody ( Cat # PAB6784 ) staining ( 1 µg/ml ) of human duodenum lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
H00006532-D01P - SLC6A4 / SERT
SLC6A4 MaxPab rabbit polyclonal antibody. Western Blot analysis of SLC6A4 expression in mouse lung.
H00006532-D01P - SLC6A4 / SERT
Western Blot analysis of SLC6A4 expression in transfected 293T cell line (H00006532-T01) by SLC6A4 MaxPab polyclonal antibody.Lane 1: SLC6A4 transfected lysate(70.30 KDa).Lane 2: Non-transfected lysate.
AP31853PU-N - SLC6A4 / SERT
Staining of Mouse Small Intestine lysate (35µg protein in RIPA buffer) using SLC6A4 Antibody Cat.-No AP31853PU-N at 0.5 µg/ml. Primary incubation was 1 hour. Detected by chemiluminescence.
TP310187 - SLC6A4 / SERT
TA303021 - SLC6A4 / SERT
TA303021 staining (1µg/ml) of Human Duodenum lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
TA328879 - SLC6A4 / SERT
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1-2. Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:200). 3-4. Anti-Serotonin Transporter (SERT) (extracellular) antibody, preincubated with the control peptide antigen.
TA328879 - SLC6A4 / SERT
Expression of SERT in mouse brain. Immunohistochemical staining of immersion-fixed, free floating mouse brain frozen sections using Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:400). A. SERT (green) was visualized in axonal fibers of the hippocampal dentate gyrus. B. Axonal fibers of neurons expressing gamma amino butyric acid (GABA) were labeled with mouse anti parvalbumin (red). C. Merge of the two images demonstrates separate axonal processes (no co-localization).
TA328879 - SLC6A4 / SERT
Expression of SERT in rat brain. Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:400). A. SERT (green) was visualized in axonal fibers of the rat hippocampal CA1 region. B. Axonal fibers of neurons expressing gamma amino butyric acid (GABA) were labeled with mouse anti parvalbumin (red). C. Merge of the two images demonstrates separate axonal processes (no co-localization).
TA328879 - SLC6A4 / SERT
Expression of Serotonin Transporter (SERT) rat PC12 cells. Immunocytochemical staining of live intact rat pheochromocytoma PC12 cells. A. Cells were stained with Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:100), followed by goat anti-rabbit-AlexaFluor- 594 secondary antibody (red). B. Cell nuclei were visualized using Hoechst 33342 (blue). C. Live view of the cells.
TA328879 - SLC6A4 / SERT
Indirect flow cytometry analysis in live intact human T cell leukemia (Jurkat) cell line:black line, Unstained cells + goat-anti-rabbit-Cy5. green line, Cells + Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:25) + goat-anti-rabbit-Cy5.
TA350956 - SLC6A4 / SERT
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (SLC6A4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
TA350956 - SLC6A4 / SERT
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (SLC6A4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
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17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC6A4 / SERT antibody
  Rabbit Polyclonal Anti-Serotonin Transporter (SERT) (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1-2. Anti-Serotonin Transporter (SERT) (extracellular) antibody, (1:200). 3-4. Anti-Serotonin Transporter (SERT) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €622.00
  OriGene Technologies, Inc.
+4 additional images

Highly validated antibody!

SLC6A4 / SERT (605-618) antibody
Staining of Mouse Small Intestine lysate (35µg protein in RIPA buffer) using SLC6A4 Antibody Cat.-No AP31853PU-N at 0.5 µg/ml. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt E, F, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH
+2 additional images

Acris recommends this product for Western blotting.

SLC6A4 / SERT antibody
  Goat Polyclonal Antibody against SLC6A4  
TA303021 staining (1µg/ml) of Human Duodenum lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

SLC6A4 / SERT antibody
  Rabbit Polyclonal Anti-SLC6A4 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (SLC6A4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

SLC6A4 / SERT antibody
SLC6A4 / SERT Mouse IgG1 2D7/3 Aff - Purified Ms, Rt C
0.1 mg / €960.00
  Acris Antibodies GmbH

SLC6A4 / SERT (579-599) antibody
Staining with 5-HT (Serotonin) Transporter Antibody 24330 Rabbit Serum Hu, Mky, Ms, Rt C, ICC/IF, WB
0.1 ml / €520.00
  ImmunoStar Inc.

SLC6A4 / SERT Control Peptide
SLC6A4 / SERT Purified
25 µg / €190.00
  ImmunoStar Inc.

SLC6A4 / SERT antibody
SLC6A4 / SERT Rabbit Serum Rt C, ICC/IF, WB
0.1 ml / €490.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

SLC6A4 - human gene knockout kit via CRISPR
SLC6A4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC6A4 - human gene knockout kit via CRISPR
SLC6A4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC6A4 - human gene knockout kit via CRISPR
SLC6A4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC6A4 - human gene knockout kit via CRISPR
SLC6A4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC6A4 / SERT
  Purified recombinant protein of Homo sapiens solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4)  
SLC6A4 / SERT Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC6A4 (mGFP-tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), 200 uL, >10^7 TU/mL
Lenti ORF particles, SLC6A4 (mGFP-tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, SLC6A4 (Myc-DDK tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) , 200 uL, >10^7 TU/mL
Lenti ORF particles, SLC6A4 (Myc-DDK tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) , 200 uL, >10^7 TU/mL  
200 µl / €969.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc6a4 (GFP-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4), 200 uL, >10^7 TU/mL
Lenti ORF particles, Slc6a4 (GFP-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4), 200 uL, >10^7 TU/mL  
200 µl / €1,329.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Slc6a4 (Myc-DDK-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4), 200 uL, >10^7 TU/mL
Lenti ORF particles, Slc6a4 (Myc-DDK-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4), 200 uL, >10^7 TU/mL  
200 µl / €1,192.00
  OriGene Technologies, Inc.
 

17 Item(s)

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17 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. CRISPR (4)
  2. Control Peptide (1)
  3. Human Lenti ORF Particle (2)
  4. Primary Antibody (7)
  5. Protein | Growth Factor (1)
  6. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (7)
  2. Monoclonal (1)
Target
  1. SLC6A4 / SERT (9)
Property
  1. 579-599 (1)
  2. 605-618 (1)
Reactivity
  1. Rat (Rt) (6)
  2. Human (Hu) (5)
  3. Mouse (Ms) (5)
  4. Bovine (Bov) (1)
  5. Monkey (Mky) (1)
Applications
  1. Western blot / Immunoblot (WB) (5)
  2. Frozen sections (C) (3)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (3)
  4. Enzyme Immunoassay (E) (2)
  5. Flow cytometry (F) (1)
  6. Paraffin Sections (P) (1)
Presentation
  1. Aff - Purified (3)
  2. Purified (3)
  3. Serum (2)
Host
  1. Rabbit (4)
  2. Goat (2)
  3. Mouse (1)
Images
  1. 1 image (7)
  2. 3+ images (2)
  3. 5+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
  3. IHC (2)
  4. Flow cytometry (F) (1)
  5. Immunofluorescence (IF) (1)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Species (CRISPR)
  1. Human (4)
Donor Vector
  1. GFP-Puro (1)
  2. Luciferase-Puro (1)
  3. RFP-BSD (1)
  4. mBFP-Neo (1)
Manufacturer
  1. Acris - OriGene (14)
  2. ImmunoStar Inc. (2)
  3. Neuromics Antibodies (1)
Service
  • OriGene EU
  • Acris Antibodies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info@acris-online.de
  • orders: ordering@acris-online.de
 
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