SLC6A5 / GLYT2 antibody

Principal name

SLC6A5 / GLYT2 antibody

Alternative names for SLC6A5 / GLYT2 antibody

GLYT-2, NET1, Solute carrier family 6 member 5, Sodium- and chloride-dependent glycine transporter 2

SwissProt ID

A7Y2X0 (Xenla), P58295 (Rat), Q761V0 (Mouse), Q9Y345 (Human)

Gene ID

9152 (SLC6A5), 171148 (Slc6a5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of SLC6A5 / GLYT2 antibody

Apart from its obvious biochemical functions, glycine is also an important inhibitory neurotransmitter. Following depolarization, glycine is released from syptic vesicles, binds to glycine receptors (GlyRs) on postsyptic membranes thereby causing hyperpolarization of postsyptic neurons due to the massive influx of Cl ions. Glycine is then taken up from the syptic cleft via the glycine transporters GlyT1 and GlyT2 . GlyT1 and GlyT2 belong to the SLC6, +/Cl dependent transporter family, of which members include transporters for GABA, serotonin, dopamine and norepinephrine. Like all SLC6 members, GlyT1 and GlyT2 have 12 transmembrane domains and intracellular N- and C-termils. Both can be found in different splice variants. SLC6 transporters undergo post-translatiol modifications. For instance, GlyT1 and GlyT2 are glycosylated, which is important for their membrane trafficking. Phosphorylation of these two transporters also takes place in a PKC-dependent manner, which may lead to down regulation of both transporters. Pharmacologically, GlyT1 and GlyT2 can be differentiated by applying sarcosine which inhibits GlyT1 but not GlyT2 . GlyT1 and GlyT2 are broadly expressed in the nervous system; GlyT1 is concentrated in glial cells, while GlyT2 is present in glycenergic neurons in the spil cord, brainstem and cerebellum. GlyT1 can also be detected in the pancreas, uterus, stomach, spleen, liver and reti. GlyT1 has become a target for the treatment of schizophrenia, although a defect of the protein is not directly associated with the disorder. Inhibiting GlyT1 should lead to the increase in glutamatergic pathways, thereby decreasing psychotic effects in schizophrenic individuals. GlyT2 has been associated with hyperekplexia, a motor disorder characterized by neotal hypertonia and startle reflex.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC6A5 / GLYT2 antibody

Western blot analysis of mouse brain (lanes 1 and 4), rat brain (lanes 2 and 5) and rat cerebellum (lanes 3 and 6) lysates: 1-3. Anti-Glycine Transporter 2 (GlyT2) (extracellular) antibody, (1:200). 4-6. Anti-Glycine Transporter 2 (GlyT2) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC6A5 / GLYT2 antibody

Host: Rabbit; Target Name: SLC6A5; Sample Tissue: COLO205 Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC6A5 / GLYT2 antibody

WB Suggested Anti-SLC6A5 Antibody Titration: 0.2-1 ug/ml; Positive Control: PANC1 cell lysate;SLC6A5 is supported by BioGPS gene expression data to be expressed in PANC1 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC6A5 / GLYT2 antibody

SLC6A5 / GLYT2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SLC6A5 / GLYT2 antibody

SLC6A5 / GLYT2 Mouse IgG1 3B3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SLC6A5 / GLYT2 antibody

Human PANC1; WB Suggested Anti-SLC6A5 Antibody Titration: 0.2-1 ug/ml. Positive Control: PANC1 cell lysate. SLC6A5 is supported by BioGPS gene expression data to be expressed in PANC1.; SLC6A5 antibody - middle region (ARP43873_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC6A5 / GLYT2

SLC6A5 / GLYT2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SLC6A5 / GLYT2

SLC6A5 / GLYT2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC6A5 (mGFP-tagged) - Human solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5), 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC6A5 (mGFP-tagged) - Human solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC6A5 (Myc-DDK tagged) - Human solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC6A5 (Myc-DDK tagged) - Human solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc6a5 (GFP-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5), 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc6a5 (GFP-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5), 200 uL, >10^7 TU/mL  
200 µl / €1,510.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc6a5 (Myc-DDK-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5), 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc6a5 (Myc-DDK-tagged ORF) - Rat solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5), 200 uL, >10^7 TU/mL  
200 µl / €1,360.00
  OriGene Technologies, Inc.

12 Item(s)

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