SLC6A9 / GLYT1 antibody

Principal name

SLC6A9 / GLYT1 antibody

Alternative names for SLC6A9 / GLYT1 antibody

GLYT-1, Solute carrier family 6 member 9, Sodium- and chloride-dependent glycine transporter 1

SwissProt ID

A7Y2W8 (Xenla), P28571 (Mouse), P28571-1, P28572 (Rat), P48067 (Human), Q28039 (Bovin)

Gene ID

6536 (SLC6A9), 14664 (Slc6a9), 116509

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SLC6A9 / GLYT1 antibody

Apart from its obvious biochemical functions, glycine is also an important inhibitory neurotransmitter. Following depolarization, glycine is released from syptic vesicles, binds to glycine receptors (GlyRs) on postsyptic membranes thereby causing hyperpolarization of postsyptic neurons due to the massive influx of Cl ions. Glycine is then taken up from the syptic cleft via the glycine transporters GlyT1 and GlyT2 . GlyT1 and GlyT2 belong to the SLC6, +/Cl dependent transporter family, of which members include transporters for GABA, serotonin, dopamine and norepinephrine. Like all SLC6 members, GlyT1 and GlyT2 have 12 transmembrane domains and intracellular N- and C-termils. Both can be found in different splice variants. SLC6 transporters undergo post-translatiol modifications. For instance, GlyT1 and GlyT2 are glycosylated, which is important for their membrane trafficking. Phosphorylation of these two transporters also takes place in a PKC-dependent manner, which may lead to down regulation of both transporters. Pharmacologically, GlyT1 and GlyT2 can be differentiated by applying sarcosine which inhibits GlyT1 but not GlyT2 . GlyT1 and GlyT2 are broadly expressed in the nervous system; GlyT1 is concentrated in glial cells, while GlyT2 is present in glycenergic neurons in the spil cord, brainstem and cerebellum. GlyT1 can also be detected in the pancreas, uterus, stomach, spleen, liver and reti. GlyT1 has become a target for the treatment of schizophrenia, although a defect of the protein is not directly associated with the disorder. Inhibiting GlyT1 should lead to the increase in glutamatergic pathways, thereby decreasing psychotic effects in schizophrenic individuals. GlyT2 has been associated with hyperekplexia, a motor disorder characterized by neotal hypertonia and startle reflex.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC6A9 / GLYT1 antibody

Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and human U87-MG glioma cell (lanes 3 and 6) lysates: 1-3. Anti-Glycine Transporter 1 (GlyT1) (extracellular) antibody, (1:200). 4-6. Anti-Glycine Transporter 1 (GlyT1) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC6A9 / GLYT1 antibody

SLC6A9 / GLYT1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

SLC6A9 / GLYT1 (C-term) antibody

Mouse Spleen; WB Suggested Anti-Slc6a9 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Spleen; Slc6a9 antibody - C-terminal region (ARP42330_P050) in Mouse Spleen cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

SLC6A9 / GLYT1 antibody

SLC6A9 / GLYT1 Rabbit Aff - Purified Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

SLC6A9 / GLYT1 antibody

Immunohistochemistry-Paraffin: SLC6A9 Antibody [NBP1-81820] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

SLC6A9 overexpression lysate

SLC6A9 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

SLC6A9 overexpression lysate

SLC6A9 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

SLC6A9 overexpression lysate

SLC6A9 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

SLC6A9 overexpression lysate

SLC6A9 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SLC6A9 overexpression lysate

SLC6A9 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

10 Item(s)

per page
  • LinkedIn