SLC7A10 / ASC1 antibody

Principal name

SLC7A10 / ASC1 antibody

Alternative names for SLC7A10 / ASC1 antibody

ASC-1, Asc-type amino acid transporter 1, Solute carrier family 7 member 10

SwissProt ID

P63115 (Mouse), P63116 (Rat), Q9NS82 (Human)

Gene ID

56301 (SLC7A10), 53896 (Slc7a10)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Dot blot (Dot), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of SLC7A10 / ASC1 antibody

Amino acid transport across the plasma membrane is mediated by both sodium-dependent and sodium independent transport mechanisms (1). The recent advances in the molecular biology techniques let to discovery of several amino acid transporters that are homologues to the amino acid transport system describe for tissue culture cells and in membrane vesicle preparations (2). It has been shown that sodium- independent amino acid transporter covalently interact with the heavy chain of a cell surface antigen 4F2 also known as CD98. Structurally, 4F2 compose of a 4F2 heavy chain (4F2hc), an integral membrane protein and a light chain that has intrinsic amino acid transport properties. Various amino acid transporters including transport type L, y+L and xc- has been shown to be the 2F4 light chains and assemble with 2F4hc for their functional amino acid transport activities (3-5). Recently a protein structurally related to amino acid transporter, with a characteristic 12 trans-membrane domains (TMDs) has been cloned mouse brain that associates with 2F4hc for its small neutral amino acid transport activity (1). This transporter belongs to the LAT2 family, a component for system L transporter. The ASC-1 showed 65% identity to LAT2, 45% to LAT1, y+LAT1 and KIAA0245/y+LAT2 type transporters (6). The transporter ASC-1 is a member of the solute carrier family 7 and serves as a cationic amino acid transporter (y+ system). The ASC-1 protein has 530 amino acids (MW 63-64 kDa) is expressed in brain, lungs and intestine. It has two consensus phosphorylation sites (PKA and PKC) that are conserved in all y+ transport system. ASC1 transporter also transports with high affinity D and L-amino acid-related compounds and may involve in glutamenergic transmission in brain by modulating D-serine at glutamiergic synapse. ASC-1 forms disulfide dimmers with ASC transporter and SLC3A2/4F2hc proteins.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC7A10 / ASC1 antibody

  Rabbit Polyclonal Anti-SLC7A10 Antibody  
Host: Rabbit; Target Name: SLC7A10; Sample Tissue: ACHN Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SLC7A10 - human gene knockout kit via CRISPR

SLC7A10 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC7A10 - human gene knockout kit via CRISPR

SLC7A10 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC7A10 - human gene knockout kit via CRISPR

SLC7A10 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC7A10 - human gene knockout kit via CRISPR

SLC7A10 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc7a10 - mouse gene knockout kit via CRISPR

Slc7a10 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc7a10 - mouse gene knockout kit via CRISPR

Slc7a10 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SLC7A10 overexpression lysate

SLC7A10 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc7a10 (GFP-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 (Slc7a10), 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc7a10 (GFP-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 (Slc7a10), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc7a10 (Myc-DDK-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 (Slc7a10), 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc7a10 (Myc-DDK-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 (Slc7a10), 200 uL, >10^7 TU/mL  
200 µl / €1,040.00
  OriGene Technologies, Inc.

10 Item(s)

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