SLC8A1 / NCX1 antibody

Principal name

SLC8A1 / NCX1 antibody

Alternative names for SLC8A1 / NCX1 antibody

CNC, Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1

SwissProt ID

P23685 (Canfa), P32418 (Human), P48765 (Bovin), P48766 (Cavpo), P48767 (Felca), P70414 (Mouse), Q01728 (Rat), Q9UKX6 (Human)

Gene ID

6546 (SLC8A1), 29715 (Slc8a1)

Available reactivities

Can (Canine), GP (Guinea Pig), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Bov (Bovine), Frog

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E)

Background of SLC8A1 / NCX1 antibody

Ca2+ has proven to be a universal sigling molecule in excitable and non-excitable cells. However, being that its intracellular concentration is 1000 time lower than the extracellular milieu, it is important for the cell to keep this ratio for proper function. NCX, a +/Ca2+ exchanger is responsible for most of the efflux of Ca2+ out from the cell.The NCX transporter is a member of the SLC8 family of solute carriers which in turn belong to the CaCA superfamily.NCX-1 is one of three +/Ca2+ exchangers (NCX-1, NCX-2, NCX-3) leading to one Ca2+ movement across the plasma membrane in exchange of three + influx. However, the transporter can reverse the direction of the transport if the concentrations of + and Ca2+ change.The transporter has nine transmembrane domains and intracellular N- and C-termils. Between tansmembrane domains 5 and 6, the presence of an extra-long intracellular loop, termed the f loop is responsible for regulating the activity of NCX-1 via several different mechanisms like ion binding, phosphorylation, etc. The f loop also has sites which undergo altertive splicing.Of the three NCX-1 expressed in mammalian cells, NCX-1 is the most widely expressed. Its expression is detected in the heart, brain, and kidney. NCX-1 undergoes altertive splicing in a tissue dependent manner. The first splice region does not change the overall structure of the protein but rather ebles the expression of the gene specific to the tissues which require the expression of the gene. The second splicing site leads to a number of proteins varying in length. NCX-2 expression is much more limited; it is expressed only in neurons. NCX-3 is expressed in skeletal muscle and in some regions of the brain and undergoes altertive splicing in a similar fashion to that of NCX-1.Due to its central role in modulating Ca2+ levels in the cell, NCX-1 has become a pharmaceutical target in the development of drugs for various heart diseases and neurological disorders.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC8A1 / NCX1 antibody

Western blot of various tissues showing specific immunolabeling of the ~120k and ~160k NaCX-1 protein.  Lane 1 - Brain; Lane 2 - Heart; Lane 3 - Kidney; Lane 4 - Lung; Lane 5 - Spleen. Mouse IgG2b 6H2 Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC8A1 / NCX1 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-Na+/Ca2+ Exchanger 1 (NCX-1) antibody , (1:200). 3, 4. Anti-Na+/Ca2+ Exchanger 1 (NCX-1) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC8A1 / NCX1 antibody

Host: Rabbit; Target Name: SLC8A1; Sample Tissue: ACHN Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC8A1 / NCX1 antibody

Western blot analysis of NCX1 expression in K562 (A); A549 (B); HL60 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SLC8A1 / NCX1 antibody

Western blot analysis of NCX1 expression in K562 (A); A549 (B); HL60 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SLC8A1 / NCX1 antibody

Western blot analysis of NCX1 expression in K562 (A); A549 (B); HL60 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SLC8A1 / NCX1 antibody

Western Blot: NCX1 Antibody [NB300-127] - Western blot of various tissues showing specific immunolabeling of the ~120k and ~160k NaCX-1 protein. Lane 1 - Brain; Lane 2 - Heart; Lane 3 - Kidney; Lane 4 - Lung; Lane 5 - Spleen. Mouse IgG2b Purified Rb WB
0.1 mg / €380.00
  Novus Biologicals Inc.

SLC8A1 / NCX1 antibody

SLC8A1 /  NCX1 Rabbit IgG Serum Bov, Frog, GP, Hu, Ms, Rb, Rt C, IP, P, WB
0.2 ml / €450.00
  Swant

8 Item(s)

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