SLC8A1 / NCX1 antibody

Principal name

SLC8A1 / NCX1 antibody

Alternative names for SLC8A1 / NCX1 antibody

CNC, Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1

SwissProt ID

P23685 (Canfa), P32418 (Human), P48765 (Bovin), P48766 (Cavpo), P48767 (Felca), P70414 (Mouse), Q01728 (Rat), Q9UKX6 (Human)

Gene ID

6546 (SLC8A1), 29715 (Slc8a1), 20541

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Frog, GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C), Paraffin Sections (P)

Background of SLC8A1 / NCX1 antibody

Ca2+ has proven to be a universal sigling molecule in excitable and non-excitable cells. However, being that its intracellular concentration is 1000 time lower than the extracellular milieu, it is important for the cell to keep this ratio for proper function. NCX, a +/Ca2+ exchanger is responsible for most of the efflux of Ca2+ out from the cell.The NCX transporter is a member of the SLC8 family of solute carriers which in turn belong to the CaCA superfamily.NCX-1 is one of three +/Ca2+ exchangers (NCX-1, NCX-2, NCX-3) leading to one Ca2+ movement across the plasma membrane in exchange of three + influx. However, the transporter can reverse the direction of the transport if the concentrations of + and Ca2+ change.The transporter has nine transmembrane domains and intracellular N- and C-termils. Between tansmembrane domains 5 and 6, the presence of an extra-long intracellular loop, termed the f loop is responsible for regulating the activity of NCX-1 via several different mechanisms like ion binding, phosphorylation, etc. The f loop also has sites which undergo altertive splicing.Of the three NCX-1 expressed in mammalian cells, NCX-1 is the most widely expressed. Its expression is detected in the heart, brain, and kidney. NCX-1 undergoes altertive splicing in a tissue dependent manner. The first splice region does not change the overall structure of the protein but rather ebles the expression of the gene specific to the tissues which require the expression of the gene. The second splicing site leads to a number of proteins varying in length. NCX-2 expression is much more limited; it is expressed only in neurons. NCX-3 is expressed in skeletal muscle and in some regions of the brain and undergoes altertive splicing in a similar fashion to that of NCX-1.Due to its central role in modulating Ca2+ levels in the cell, NCX-1 has become a pharmaceutical target in the development of drugs for various heart diseases and neurological disorders.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Na+-Ca2+-exchanger antibody

Na+-Ca2+-exchanger Mouse IgG1 Lyophilized C, IP, WB
0.2 ml / €590.00
  Swant

SLC8A1 / NCX1 antibody

Western blot of various tissues showing specific immunolabeling of the ~120k and ~160k NaCX-1 protein.  Lane 1 - Brain; Lane 2 - Heart; Lane 3 - Kidney; Lane 4 - Lung; Lane 5 - Spleen. Mouse IgG2b 6H2 Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC8A1 / NCX1 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-Na+/Ca2+ Exchanger 1 (NCX-1) antibody , (1:200). 3, 4. Anti-Na+/Ca2+ Exchanger 1 (NCX-1) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC8A1 / NCX1 antibody

Host: Rabbit; Target Name: SLC8A1; Sample Tissue: ACHN Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC8A1 / NCX1 antibody

Western blot analysis of NCX1 expression in K562 (A); A549 (B); HL60 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SLC8A1 / NCX1 antibody

Western blot analysis of NCX1 expression in K562 (A); A549 (B); HL60 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SLC8A1 / NCX1 antibody

Western blot analysis of NCX1 expression in K562 (A); A549 (B); HL60 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SLC8A1 / NCX1 antibody

SLC8A1 /  NCX1 Rabbit IgG Serum Bov, Frog, GP, Hu, Ms, Rb, Rt C, IP, P, WB
0.2 ml / €450.00
  Swant

CRISPR

Catalog No. Species Donor Vector  

SLC8A1 - human gene knockout kit via CRISPR

SLC8A1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC8A1 - human gene knockout kit via CRISPR

SLC8A1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC8A1 - human gene knockout kit via CRISPR

SLC8A1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC8A1 - human gene knockout kit via CRISPR

SLC8A1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc8a1 - mouse gene knockout kit via CRISPR

Slc8a1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc8a1 - mouse gene knockout kit via CRISPR

Slc8a1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc8a1 - mouse gene knockout kit via CRISPR

Slc8a1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc8a1 - mouse gene knockout kit via CRISPR

Slc8a1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC8A1 (mGFP-tagged) - Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant A, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC8A1 (mGFP-tagged) - Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant A, 200 uL, >10^7 TU/mL  
200 µl / €2,000.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC8A1 (mGFP-tagged)-Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant B, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC8A1 (mGFP-tagged)-Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant B, 200 uL, >10^7 TU/mL  
200 µl / €1,990.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC8A1 (mGFP-tagged)-Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant C, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC8A1 (mGFP-tagged)-Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant C, 200 uL, >10^7 TU/mL  
200 µl / €1,980.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC8A1 (Myc-DDK tagged) - Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant A , 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC8A1 (Myc-DDK tagged) - Human solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant A , 200 uL, >10^7 TU/mL  
200 µl / €1,800.00
  OriGene Technologies, Inc.

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