SLC9A2 / NHE2 antibody

Principal name

SLC9A2 / NHE2 antibody

Alternative names for SLC9A2 / NHE2 antibody

NHE-2, Sodium/hydrogen exchanger 2, Solute carrier family 9 member 2, Na(+)/H(+) exchanger 2

SwissProt ID

P48763 (Rat), P50482 (Rabit), Q9UBY0 (Human)

Gene ID

6549 (SLC9A2), 24783 (Slc9a2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P)

Background of SLC9A2 / NHE2 antibody

In order to function in optimal conditions, cells must maintain a close to neutral intracellular pH. They have adopted various mechanisms in order to do so, one of which is via +/H+ exchangers (NHEs). Genes belonging to this group are expressed along a very broad range of organisms and are essential for protecting cells against intracellular acidification.To date, nine genes have been identified in mammals; NHE1-9. These membrane proteins have 10-12 transmembrane domains depending on whether a splice variant is expressed and an intracellular N-termil. The C-termil domain can be either intracellular or extracellular, also depending whether a splice variant of the protein is involved. The C-termil part of the protein also undergoes posttranslatiol modification such as phosphorylation. Both NHE-1 and NHE-2 have an extracellular loop which is glycosylated.Under physiological conditions, the +/H+ exchanger mediates the exchange of one extracellular + ion for one intracellular proton, thereby keeping the overall charge neutral1. The extracellular binding site of + is not selective as it can also bind Li+ and H+,K+ ions inhibit NHE-1 but have no effect on NHE-2.The activation of NHE-1 and NHE-2 is sensitive to intracellular acidic pH. Under physiological conditions, both exchangers are not active and upon a drop of intracellular pH, they are rapidly activated.NHE-2 is detected in the intestine, kidney and parietal cells.It is also detected in skeletal muscle and testis.

4 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC9A2 / NHE2 antibody

Western blot analysis of rat kidney membranes (lanes 1 and 4), mouse kidney lysate (lanes 2 and 5) and rat stomach lysate (lanes 3 and 6): 1-3. Anti-Na+/H+ Exchanger 2 (NHE-2) antibody , (1:200). 4-6. Anti-Na+/H+ Exchanger 2 (NHE-2) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC9A2 / NHE2 antibody

SLC9A2 / NHE2 Rabbit Purified Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

SLC9A2 / NHE2 antibody

Immunohistochemistry-Paraffin: SLC9A2 Antibody [NBP1-82576] Immunohistochemical staining of human stomach shows moderate luminal membrane and cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

SLC9A2 overexpression lysate

SLC9A2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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