SLIT1 antibody

Principal name

SLIT1 antibody

Alternative names for SLIT1 antibody

SLIT-1, KIAA0813, MEGF4, SLIL1, Slit homolog 1 protein, Multiple epidermal growth factor-like domains protein 4

SwissProt ID

O75093 (Human), O88279 (Rat), Q80TR4 (Mouse)

Gene ID

20562 (Slit1), 6585 (SLIT1)

Available reactivities

Ms (Mouse), Rt (Rat), Chk (Chicken), Frog, Hu (Human), Ze (Zebrafish), African clawed frog, Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts


Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of SLIT1 antibody

SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein.

General readings

1. Long,H., Sabatier,C., Ma,L., Plump,A., Yuan,W., Ornitz,D.M., Tamada,A., Murakami,F., Goodman,C.S. and Tessier-Lavigne,M. (2004) Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron 42 (2), 213-223.
2. Nguyen-Ba-Charvet,K.T., Picard-Riera,N., Tessier-Lavigne,M., Baron-Van Evercooren,A., Sotelo,C. and Chedotal,A. (2004) Multiple roles for slits in the
control of cell migration in the rostral migratory stream. J. Neurosci. 24 (6), 1497-1506.
3. Knoll,B., Schmidt,H., Andrews,W., Guthrie,S., Pini,A., Sundaresan,V. and Drescher,U. (2003) On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion. Development 130 (21), 5073-5082.
4. Luukko,K., Loes,S., Furmanek,T., Fjeld,K., Kvinnsland,I.H. and Kettunen,P. (2003) Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. Mech. Dev. 120 (3), 270-276.
5. Nguyen-Ba-Charvet,K.T., Plump,A.S., Tessier-Lavigne,M. and Chedotal,A. (2002) Slit1 and slit2 proteins control the development of the lateral olfactory tract. J. Neurosci. 22 (13), 5473-5480.
6. Causeret,F., Danne,F., Ezan,F., Sotelo,C. and Bloch-Gallego,E. (2002) Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev. Biol. 246 (2), 429-440.
7. Little,M., Rumballe,B., Georgas,K., Yamada,T. and Teasdale,R.D. (2002) Conserved modularity and potential for alternate splicing in mouse and human Slit genes. Int. J. Dev. Biol. 46 (4), 385-391.
8. Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M. (1999) The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev. Biol. 212 (2), 290-306.

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLIT1 (487-504) antibody

SLIT1 Rabbit IgG Aff - Purified Ms E, WB
  OriGene Technologies, Inc.

SLIT1 antibody

SLIT1 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
  OriGene Technologies, Inc.

SLIT1 (487-504) antibody

SLIT1 Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
  Acris Antibodies GmbH

SLIT1 antibody

SLIT1 Rabbit Chk, Frog, Hu, Ms, Rt E, WB
  Abnova Taiwan Corp.

SLIT1 antibody

SLIT1 Rabbit Aff - Purified African clawed frog, Chk, Hu, Ms, Rt, Ze P, WB
  AVIVA Systems Biology

SLIT1 antibody

SLIT1 Rabbit IgG Aff - Purified Ms, Rt E, WB
  Novus Biologicals Inc.

SLIT1 antibody

SLIT1 Rabbit IgG Aff - Purified Hu ICC/IF, P
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLIT1 (His-tagged)

SLIT1 Human Purified > 80 % CHO cells
  Neuromics Antibodies

8 Item(s)

per page
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