Sm / Smith Antigen antibody

Principal name

Sm / Smith Antigen antibody

Alternative names for Sm / Smith Antigen antibody

Human Autoantigens

Available reactivities

Dros (Drosophila), Hu (Human), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Human

Available applications

Immunoelectron Microscopy (EM), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunodiffusion (ID)

Background of Sm / Smith Antigen antibody

The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE. This antibody recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. It precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sm (Smith Antigen) antibody

Sm (Smith Antigen) Human Purified Hu E, ID
  Acris Antibodies GmbH

Sm (Smith Antigen) antibody

Sm (Smith Antigen) Mouse IgG3 Y12 Purified Dros, Hu, Por, Rb, Rt EM, ICC/IF, P, WB
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sm (Smith Antigen)

Sm (Smith Antigen) Bovine Aff - Purified Immobilized human anti-Sm immune globulins. Purification is verified by SDS PAGE. Other antigens (SSA, SSB, RNP, Scl-70, Jo-1) are not detected with ELISA assays. Spleen
  Acris Antibodies GmbH

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