SMARCB1 antibody

Principal name

SMARCB1 antibody

Alternative names for SMARCB1 antibody

Integrase interactor 1 protein, INI1, SNF5 homolog, SNF5L1, BAF47, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47

SwissProt ID

P18480 (Yeast), Q09699 (Schpo), Q12824 (Human), Q5BIN2 (Bovin), Q5U379 (Danre), Q5ZK40 (Chick), Q6GQ82 (Xenla), Q9Z0H3 (Mouse)

Gene ID

6598 (SMARCB1), 20587 (Smarcb1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), African clawed frog, Rt (Rat), Chk (Chicken), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of SMARCB1 antibody

Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

General readings

Mueller,W., et al., (2004) Neuropathol Appl Neurobiol 30 (3), 304-307

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SMARCB1 (81-181) antibody

Formalin-Fixed, Paraffin-Embedded Human Colon stained with Anti-SMARCB1 antibody at 10 ug/ml. Mouse IgG1 3E10 Purified Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SMARCB1 antibody

  Rabbit anti-SMARCB1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using SMARCB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

  Rabbit Polyclonal Anti-SMARCB1 Antibody  
WB Suggested Anti-SMARCB1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

  Rabbit Polyclonal Anti-SMARCB1 Antibody  
WB Suggested Anti-SMARCB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysateSMARCB1 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

  Rabbit Polyclonal Anti-SMARCB1 Antibody  
Host: Rabbit; Target Name: SMARCB1; Sample Tissue: Lymph Node Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

  Rabbit Polyclonal Anti-SMARCB1 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Jurkat cells, K562 cells, hepg2 cells, Primary antibody: (SMARCB1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

Formalin-Fixed, Paraffin-Embedded Human astrocytoma stained with INI1 antibody Cat.-No. AM10099SU-N using peroxidase conjugate and DAB chromogen. Note the nuclear staining of malignant glial cells. Mouse IgG2a 25 Supernatant Hu P
1 ml / €590.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SMARCB1 - human gene knockout kit via CRISPR

SMARCB1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SMARCB1 - human gene knockout kit via CRISPR

SMARCB1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SMARCB1 - human gene knockout kit via CRISPR

SMARCB1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SMARCB1 - human gene knockout kit via CRISPR

SMARCB1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Smarcb1 - mouse gene knockout kit via CRISPR

Smarcb1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Smarcb1 - mouse gene knockout kit via CRISPR

Smarcb1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Smarcb1 - mouse gene knockout kit via CRISPR

Smarcb1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Smarcb1 - mouse gene knockout kit via CRISPR

Smarcb1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SMARCB1 (transcript variant 2)

  Recombinant protein of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 2  
SMARCB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SMARCB1 overexpression lysate

SMARCB1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SMARCB1 (mGFP-tagged) - Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SMARCB1 (mGFP-tagged) - Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, SMARCB1 (mGFP-tagged) - Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SMARCB1 (mGFP-tagged) - Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SMARCB1 (Myc-DDK tagged) - Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SMARCB1 (Myc-DDK tagged) - Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

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