SMARCB1 antibody

Principal name

SMARCB1 antibody

Alternative names for SMARCB1 antibody

Integrase interactor 1 protein, INI1, SNF5 homolog, SNF5L1, BAF47, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47

SwissProt ID

P18480 (Yeast), Q09699 (Schpo), Q12824 (Human), Q5BIN2 (Bovin), Q5U379 (Danre), Q5ZK40 (Chick), Q6GQ82 (Xenla), Q9Z0H3 (Mouse)

Gene ID

6598 (SMARCB1), 799716 (smarcb1a), 65985 (AACS), 3623 (INHA)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), African clawed frog, Rt (Rat), Chk (Chicken), Ze (Zebrafish), Fi (Fish), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of SMARCB1 antibody

Chromatin, the physiological packaging structure of histone proteins and DNA, is considered a key element in regulating gene expression. Several complexes involved in transcriptional regulation function by either modifying histones or altering chromatin structure. Postranslational modifications of histones, such as acetylation, phosphorylation and methylation, contribute to the regulation of transcription. The ATP-dependent chromatin-remodeling complexes alter chromatin structure by using the energy of ATP hydrolysis to locally disrupt the association of histones with DNA, displacing the nucleosomes from promoter and enhancer regions, and therefore allowing transcription initiation. Chromatin remodeling complexes have been purified from a variety of organisms, and most cell types contain more than one type of complex. These complexes contain structurally related catalytic subunits, but differ in the way in which they manipulate chromatin. Three families of complexes have been described the SWI/SNF family, ISWI family, and Mi-2 family. The SWI/SNF family of ATP-dependent remodeling complexes was identified in yeast, drosophila, and human. It causes nucleosomes to change structure and/or position in order to allow transcriptional activators to gain access to their target sites. The SWI/SNF complex was originally identified in yeast as a 2 MDa complex, later shown to be highly conserved in all eukaryotes. Components of the hSWI/SNF complexes have been implicated in a range of cellular events including gene activation, regulation of cell growth, and development. The human homologue of yeast SNF5, SMARCB1, was identified in a two-hybrid screening performed to identify binding targets of the integrase of HIV, and the gene called INI1. Many studies have indicated that yeast SNF and its human counterparts are able to interact with sequence-specific transcription factors, which may recruit the complex to specific genes. For example, it has been shown that SMARCB1 interacts with the protooncogene c-Myc and the SWI complex is necessary for c-Myc mediated transactivation. Mutations in SNF5 and Brg1, both SWI components, suggest a connection of the complex with cancer. In fact, SMARCB1 displays properties of a tumor-suppressor gene, as sporadic rhabdoid tumors show biallelic loss-of-function mutations, and germline mutations confer and autosomal-dominant syndrome that predisposes patients to a variety of rhabdoid cancers.

General readings

Mueller,W., et al., (2004) Neuropathol Appl Neurobiol 30 (3), 304-307

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SMARCB1 (81-181) antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3E10 Purified Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SMARCB1 antibody

Immunoperoxidase of purified MaxPab antibody to SMARCB1 on formalin-fixed paraffin-embedded human esophagus. [antibody concentration 3 ug/ml] Mouse Purified Hu E(detection), ICC/IF, P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between SMARCB1 and BAZ1B. Huh7 cells were stained with anti-SMARCB1 rabbit purified polyclonal 1:1200 and anti-BAZ1B mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SMARCB1 antibody

Immunoperoxidase of monoclonal antibody to SMARCB1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3ug/ml] Mouse IgG1 3E10 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 monoclonal antibody (M02), clone 3E3. Western Blot analysis of SMARCB1 expression in NIH/3T3(Cat # L018V1 ). Mouse IgG1 3E3 Purified Hu, Ms, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

Immunohistochemistry staining of Paraffin Brain, endothelial cells tissue by INI-1 antibody (dilution: 1:100 - 1:500; visualization of staining: Nuclear) Mouse IgG2a MRQ-27 Purified Hu P
1 ml / €670.00
  OriGene Technologies, Inc.

SMARCB1 antibody

Western blot analysis of extracts of various cell lines, using SMARCB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

WB Suggested Anti-SMARCB1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

WB Suggested Anti-SMARCB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysateSMARCB1 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

Host: Rabbit; Target Name: SMARCB1; Sample Tissue: Lymph Node Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMARCB1 antibody

Formalin-Fixed, Paraffin-Embedded Human astrocytoma stained with INI1 antibody Cat.-No. AM10099SU-N using peroxidase conjugate and DAB chromogen. Note the nuclear staining of malignant glial cells. Mouse IgG2a 25 Supernatant Hu P
1 ml / €570.00
  Acris Antibodies GmbH

SMARCB1 antibody

SMARCB1 Mouse IgG2a MRQ-27 Supernatant Hu C, P
1 ml / €950.00
  Acris Antibodies GmbH

SMARCB1 antibody

SMARCB1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 MaxPab rabbit polyclonal antibody. Western Blot analysis of SMARCB1 expression in mouse intestine. Rabbit Serum Hu, Ms E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

SMARCB1 antibody

Western Blot analysis of SMARCB1 expression in transfected 293T cell line (H00006598-T02) by SMARCB1 MaxPab polyclonal antibody.

Lane 1: SMARCB1 transfected lysate(44.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 monoclonal antibody (M03), clone 3C4 Western Blot analysis of SMARCB1 expression in Hela NE ( Cat # L013V3 ). Mouse IgG2b 3C4 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 monoclonal antibody (M04), clone 3H3 Western Blot analysis of SMARCB1 expression in Hela NE ( Cat # L013V3 ). Mouse IgG2b 3H3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 monoclonal antibody (M06), clone 2A3. Western Blot analysis of SMARCB1 expression in Hela NE(Cat # L013V3 ). Mouse IgG2b 2A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 Mouse IgG2a 3F11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMARCB1 antibody

SMARCB1 monoclonal antibody (M12), clone 2D10. Western Blot analysis of SMARCB1 expression in human ovary cancer. Mouse IgG2b 2D10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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