Alternative names for SMG6 antibody
C17orf31, EST1A, KIAA0732, EST1-like protein A, Smg-6 homolog, hSmg5/7a, Telomerase-binding protein EST1A, Ever shorter telomeres 1A, Telomerase subunit EST1A
Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)
Background of SMG6 antibody
This gene encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC); interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene.