SMN1 / SMN2 antibody

Principal name

SMN1 / SMN2 antibody

Alternative names for SMN1 / SMN2 antibody

SMN, SMNT, SMNC, Survival motor neuron protein, Component of gems 1, Gemin1, Gemin-1

SwissProt ID

O02771 (Canfa), O18870 (Bovin), O35876 (Rat), P97801 (Mouse), Q16637 (Human), Q8HYB8 (Felca)

Gene ID

6606 (SMN1), 6607 (SMN2), 20595 (Smn1)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey), Prim (Primate), Xen (Xenopus), Eq (Equine), Gt (Goat), Rb (Rabbit), Bov (Bovine), GP (Guinea Pig)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of SMN1 / SMN2 antibody

SMN1 localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein.This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants are produced by this gene.

General readings

1. Setola V, Terao M, Locatelli D, Bassanini S, Garattini E, Battaglia G.
Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis.
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1959-64. Epub 2007 Jan 29. PMID: 17261814

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SMN1 / SMN2 antibody

WB Suggested Anti-SMN1 Antibody; Titration: 0.2-1 ug/ml; Positive Control: HepG2 Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMN1 / SMN2 antibody

Immunohistochemical analysis of paraffin-embedded testis tissues (left) and lung cancer tissues (right) using SMN1 mouse mAb with DAB staining. Mouse IgG1 2F1 Ascites Hu, Mky E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

SMN1 / SMN2 antibody

Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and testis tissues (right) using SMN1 mouse mAb with DAB staining. Mouse IgG1 5H1 Ascites Hu, Mky E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

SMN1 / SMN2 antibody

Hum. Fetal Muscle; Host: Rabbit. Target Name: NOP56 . Sample Tissue: Human Fetal Muscle . Antibody Dilution: 1.0ug/ml.; SMN1 antibody - N-terminal region (ARP40209_P050) in Hum. Fetal Muscle cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SMN1 / SMN2 (Isoforms b and d of SMN1) (All isoforms of SMN2) antibody

TA303208 (2µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SMN1 / SMN2 antibody

Western Blot: SMN Antibody (2B1) [TA336277] - Western blot analysis of SMN expression in 1) HeLa, 2) NTera2, 3) HepG2, 4) MCF7, 5) NIH 3T3, 6) PC12 and 7) COS7 whole cell lysates. Mouse IgG1 2B1 Purified Hu, Ms, Prim, Rt, Xen E, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SMN1 / SMN2 antibody

WB Suggested Anti-SMN2 Antibody; Titration: 1.0 ug/ml; Positive Control: Jurkat Whole Cell SMN2 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Can, Eq, Gt, Hu, Ms, Por, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMN1 / SMN2 antibody

WB Suggested Anti-SMN1 Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SMN1 / SMN2 antibody

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: 293T cells, Raji cells, Primary antibody: (SMN1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse IgG1 SCB3 Purified Hu C, E, IP, WB
50 µg / €290.00
  Acris Antibodies GmbH

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN2 MaxPab polyclonal antibody. Western Blot analysis of SMN2 expression in human kidney. Mouse Purified Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN1 / SMN2 Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse IgG2a 2B11-2A9 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

SMN1 / SMN2 Mouse IgG2a 1A3-2B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

The SMN1/SMN2 polyclonal antibody ( Cat # PAB7236 ) ( 2 µg/ml ) staining of human brain ( cerebellum ) lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Purified Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

SMN1 / SMN2 antibody

The cell lysate derived from HeLa was immunoprobed by SMN1 polyclonal antibody ( Cat # PAB12734 ) at 1 : 500.
An immunoreactive band is observed around ~35 kDa ( 1 ). This band is abolished by pre-incubation with immunizing peptide ( 2 ). Rabbit IgG Hu C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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