SMURF1 antibody

Principal name

SMURF1 antibody

Alternative names for SMURF1 antibody

SMURF 1, SMURF-1, KIAA1625, E3 ubiquitin-protein ligase SMURF1, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1

SwissProt ID

Q9CUN6 (Mouse), Q9HCE7 (Human), Q9PUN2 (Xenla)

Gene ID

57154 (SMURF1), 75788 (Smurf1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of SMURF1 antibody

Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e.g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SMURF1 (66-96) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with SMURF1 antibody AP22777PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms P, WB
0.2 ml / €470.00
  Acris Antibodies GmbH

SMURF1 (165-269) antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1D7 Purified Hu, Ms E, ICC/IF, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SMURF1 antibody

  Rabbit Polyclonal Anti-SMURF1 Antibody  
Western blot analysis of SMURF1 in 293 cell lysate with SMURF1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SMURF1 antibody

  Rabbit Polyclonal Anti-SMURF1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (SMURF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SMURF1 (N-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with hSMURF1-W81 (AP11952PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SMURF1 (C-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SMURF1 (Center) antibody

SMURF1 Antibody (Center) (Cat. #AP53953PU-N) western blot analysis in mouse Neuro-2a cell line lysates (35µg/lane).This demonstrates the SMURF1 antibody detected the SMURF1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SMURF1 - human gene knockout kit via CRISPR

SMURF1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SMURF1 - human gene knockout kit via CRISPR

SMURF1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SMURF1 - human gene knockout kit via CRISPR

SMURF1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SMURF1 - human gene knockout kit via CRISPR

SMURF1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Smurf1 - mouse gene knockout kit via CRISPR

Smurf1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Smurf1 - mouse gene knockout kit via CRISPR

Smurf1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Smurf1 - mouse gene knockout kit via CRISPR

Smurf1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Smurf1 - mouse gene knockout kit via CRISPR

Smurf1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SMURF1 (transcript variant 2)

  Recombinant protein of human SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 2  
SMURF1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SMURF1 overexpression lysate

SMURF1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

SMURF1 overexpression lysate

SMURF1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

SMURF1 overexpression lysate

SMURF1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SMURF1 (mGFP-tagged) - Human SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SMURF1 (mGFP-tagged) - Human SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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