snRNP-N / Sm-N antibody

Principal name

snRNP-N / Sm-N antibody

Alternative names for snRNP-N / Sm-N antibody

Sm protein N, SNRPN, HCERN3, SMN, Small nuclear ribonucleoprotein-associated protein N, Tissue-specific-splicing protein

SwissProt ID

P63162 (Human), P63163 (Mouse), P63164 (Rat), Q17QN3 (Bovin)

Gene ID

6638 (SNRPN), 20646 (Snrpn), 84704 (Snurf), 81781

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of snRNP-N / Sm-N antibody

SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family.SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

General readings

1. Bielinska, B., Blaydes, S. M., Buiting, K., Yang, T., Krajewska-Walasek, M., Horsthemke, B.,
Brannan, C. I. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a
paternal to maternal imprint switch. Nature Genet. 25: 74-78, 2000.
2. Cattanach, B. M., Barr, J. A., Evans, E. P., Burtenshaw, M., Beechey, C. V., Leff, S. E., Brannan, C.
I., Copeland, N. G., Jenkins, N. A., Jones, J. A candidate mouse model for Prader-Willi syndrome
which shows an absence of Snrpn expression. Nature Genet. 2: 270-274, 1992.
3. Geuns, E., De Rycke, M., Van Steirteghem, A., Liebaers, I. Methylation imprints of the imprint
control region of the SNRPN-gene in human gametes and preimplantation embryos. Hum. Molec.
Genet. 12: 2873-2879, 2003.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

snRNP-N / Sm-N antibody

WB Suggested Anti-SNRPN Antibody; Titration: 1.0 ug/ml; Positive Control: THP-1 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

snRNP-N / Sm-N antibody

Western blot analysis of SNRPN in THP-1 cell lysate with SNRPN antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

snRNP-N / Sm-N antibody

Western Blot analysis of SNRPN expression in transfected 293T cell line (H00006638-T01) by SNRPN MaxPab polyclonal antibody.

Lane 1: SNRPN transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

snRNP-N / Sm-N (N-term) antibody

Human THP-1; WB Suggested Anti-SNRPN Antibody. . Titration: 1.0 ug/ml. . Positive Control: THP-1 Whole Cell; SNRPN antibody - N-terminal region (ARP40450_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

snRNP-N / Sm-N antibody

snRNP-N / Sm-N Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €290.00
  Boster Immunoleader

CRISPR

Catalog No. Species Donor Vector  

Snurf - mouse gene knockout kit via CRISPR

Snurf - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Snurf - mouse gene knockout kit via CRISPR

Snurf - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Snurf - mouse gene knockout kit via CRISPR

Snurf - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Snurf - mouse gene knockout kit via CRISPR

Snurf - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

snRNP-N / Sm-N (transcript variant 2)

snRNP-N / Sm-N Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

snRNP-N / Sm-N

snRNP-N / Sm-N Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SNRPN 293T Cell Transient Overexpression Lysate(Denatured)

SNRPN 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SNRPN (mGFP-tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (mGFP-tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (mGFP-tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (mGFP-tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (mGFP-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (mGFP-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (mGFP-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (mGFP-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (Myc-DDK tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (Myc-DDK tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (Myc-DDK tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (Myc-DDK tagged) - Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (Myc-DDK-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (Myc-DDK-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, SNRPN (Myc-DDK-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SNRPN (Myc-DDK-tagged)-Human small nuclear ribonucleoprotein polypeptide N (SNRPN), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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