snRNP-N / Sm-N antibody

Principal name

snRNP-N / Sm-N antibody

Alternative names for snRNP-N / Sm-N antibody

Sm protein N, SNRPN, HCERN3, SMN, Small nuclear ribonucleoprotein-associated protein N, Tissue-specific-splicing protein

SwissProt ID

P63162 (Human), P63163 (Mouse), P63164 (Rat), Q17QN3 (Bovin)

Gene ID

6638 (SNRPN)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of snRNP-N / Sm-N antibody

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq]. Transcript Variant: This variant (1) utilizes alternative exon 1 and represents the predominant variant. Since this variant alone contains exon 1, it is the only one which also contains the complete open reading frame for SNURF. Alternative splicing takes place only in the 5' UTR, resulting in variants that all share exons 2-10, encoding identical proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Bielinska, B., Blaydes, S. M., Buiting, K., Yang, T., Krajewska-Walasek, M., Horsthemke, B.,
Brannan, C. I. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a
paternal to maternal imprint switch. Nature Genet. 25: 74-78, 2000.
2. Cattanach, B. M., Barr, J. A., Evans, E. P., Burtenshaw, M., Beechey, C. V., Leff, S. E., Brannan, C.
I., Copeland, N. G., Jenkins, N. A., Jones, J. A candidate mouse model for Prader-Willi syndrome
which shows an absence of Snrpn expression. Nature Genet. 2: 270-274, 1992.
3. Geuns, E., De Rycke, M., Van Steirteghem, A., Liebaers, I. Methylation imprints of the imprint
control region of the SNRPN-gene in human gametes and preimplantation embryos. Hum. Molec.
Genet. 12: 2873-2879, 2003.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

snRNP-N / Sm-N antibody

WB Suggested Anti-SNRPN Antibody; Titration: 1.0 ug/ml; Positive Control: THP-1 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

snRNP-N / Sm-N antibody

Western blot analysis of SNRPN in THP-1 cell lysate with SNRPN antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

snRNP-N / Sm-N antibody

Western Blot analysis of SNRPN expression in transfected 293T cell line (H00006638-T01) by SNRPN MaxPab polyclonal antibody.

Lane 1: SNRPN transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

snRNP-N / Sm-N (N-term) antibody

Human THP-1; WB Suggested Anti-SNRPN Antibody. . Titration: 1.0 ug/ml. . Positive Control: THP-1 Whole Cell; SNRPN antibody - N-terminal region (ARP40450_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

snRNP-N / Sm-N antibody

snRNP-N / Sm-N Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €290.00
  Boster Immunoleader

snRNP-N / Sm-N antibody

snRNP-N / Sm-N Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

snRNP-N / Sm-N antibody

Immunohistochemistry-Paraffin: SNRPN Antibody [NBP1-83280] - Immunohistochemical staining of human lateral ventricle shows strong nuclear positivity in neuronal cells and glial cells. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

snRNP-N / Sm-N (transcript variant 2)

snRNP-N / Sm-N Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

snRNP-N / Sm-N

snRNP-N / Sm-N Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SNRPN 293T Cell Transient Overexpression Lysate(Denatured)

SNRPN 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

10 Item(s)

per page
  • LinkedIn