SOCS1 antibody

Principal name

SOCS1 antibody

Alternative names for SOCS1 antibody

Suppressor of cytokine signaling 1, SOCS-1, SSI1, SSI-1, TIP3, TIP-3, JAB, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3

SwissProt ID

O15524 (Human), O35716 (Mouse), Q9QX78 (Rat)

Gene ID

8651 (SOCS1), 252971 (Socs1)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Chk (Chicken), Rt (Rat), Bov (Bovine), Rb (Rabbit), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SOCS1 antibody

Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways. Proteins that mediate these signals from the cell surface to the nucleus include Janus kinases, e.g., Janus kinase 1, and the signal transducers and activators of transcription (STATs), such as STAT1. To maintain tight control of these signal transduction pathways, mechanisms for turning off the signals are necessary. The adverse consequences of an imbalance between positive and negative signals is evident in the motheaten mouse, which lacks the phosphatase SHP1. These mice fail to regulate cytokine responses appropriately, resulting in hyperproliferation and accumulation of cells in several hematopoietic lineages and the development of systemic autoimmune disease. SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.

General readings

1. Larsen L, Ropke C. Suppressors of Cytokine Signaling: SOCS. APMIS. December 2002; 110(12):833-844.
2. Oh J, Hur MW, Lee CE. SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates JAK to suppress ROS mediated apoptosis. Oncogene. 3 September 2009; 28(35):3145-3156.
3. Yandava CN, Pillari A, Drazen JM. Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. Genomics. 1 October 1999; 61(1):108-111.
4. Starr R, Wilson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signaling. Nature. 26 June 1997; 6636:917-921.
5. Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, Mattfeldt T, Barth TF, Muller P. Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with delayed degradation of JAK2 protein. Oncogene. 2006; 25(18):2679-2684.
6. Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB. SOCS-1 localizes to the microtubule organizing complexassociated
20S proteasome. Mol Cell Biol. 2004; 24(20):9092-9101.

  1. Quick-Filters:
  2. Highly Validated (1)

Items 1 to 20 of 38 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOCS1 antibody

Human Kidney; Rabbit Anti-SOCS1 Antibody. Catalog Number: ARP42147. Paraffin Embedded Tissue: Human Kidney. Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; SOCS1 antibody - N-terminal region (ARP42147_T100) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified Can, Chk, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

SOCS1 (C-term) antibody

TA302691 staining (2µg/ml) of mouse spleen lysate (RIPA buffer,  35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
20 µg / €200.00
  Acris Antibodies GmbH

SOCS1 (C-term) antibody

TA302691 staining (2µg/ml) of mouse spleen lysate (RIPA buffer,  35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOCS1 (C-term) antibody

Western blot analysis of SOCS1 in Human spleen cell lysate with SOCS1 antibody at (A) 1, (B) 2 and (C) 4 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOCS1 (N-term) antibody

Western blot analysis of SOCS1 in Human spleen cell lysate with SOCS1 antibody at (A) 1, (B) 2 and (C) 4 µg/ml. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOCS1 antibody

Predicted band size: 24 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/1000-5000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/1300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS1 antibody

Predicted band size: 24kDa. Positive control: HT-29 and 231 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: HT-29 cell lysate Lane2: 231 cell lysate Lysates: 40 ug per lane Primary antibody: 1/1700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS1 antibody

Western Blot: SOCS1 Antibody [TA336433] - Western blot analysis of SOCS1 using TA336433 at 1:1000 dilution against 15 ug/lane of Ramos (A) and Raw (B) cell lysate. Rabbit Purified Hu, Ms WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

SOCS1 (2-78) antibody

Western blot analysis of GST-SOCS-1 (2-78 a.a.) using AM26561AF-N. Mouse IgG1 4H1 Azide Free Ms IP, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

SOCS1 (2-78) antibody

Immunoprecipitation of SOCS-1 from mouse splenocytes with mouse IgG1 (1), AM26561AF-N (2), and from mouse hepatocytes with mouse IgG1 (3), AM26561AF-N (4). After immunoprecipitated with the antibody, immunocomplex was resolved on SDS-PAGE and immunoblotted with AM26561BT-N. Mouse IgG1 4H1 Biotin Ms WB
0.1 ml / €390.00
  Acris Antibodies GmbH

SOCS1 antibody

Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SOCS1 antibody

Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SOCS1 Control Peptide

SOCS1
0.1 mg / €250.00
  Acris Antibodies GmbH

SOCS1 antibody

SOCS1 Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SOCS1 (N-term) antibody

Western blot analysis of SOCS1 Antibody (N-term) (AP18204PU-N) in mouse kidney tissue lysates (35ug/lane). SOCS1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SOCS1 antibody

Western blot analysis of SOCS-1 in extracts from Jurkat cells using SOCS1 / JAB antibody (Cat.-No. AP20630PU-N). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SOCS1 (C-term) antibody

Immunohistochemical analysis of paraffin-embedded rat tissue sections (lung), staining SOCS1 in nucleus, DAB chromogenic reaction Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

SOCS1 Control Peptide

SOCS1
50 µg / €160.00
  Acris Antibodies GmbH

SOCS1 Control Peptide

SOCS1
50 µg / €160.00
  Acris Antibodies GmbH

SOCS1 antibody

SOCS1 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

Items 1 to 20 of 38 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn