SOCS2 / CIS2 antibody

Principal name

SOCS2 / CIS2 antibody

Alternative names for SOCS2 / CIS2 antibody

Suppressor of cytokine signaling 2, SOCS-2, CIS-2, SSI2, SSI-2, STATI2, Cytokine-inducible SH2 protein 2, STAT-induced STAT inhibitor 2

SwissProt ID

O14508 (Human), O35717 (Mouse), O88582 (Rat), Q7YRV6 (Pig), Q861R0 (Bovin)

Gene ID

8835 (SOCS2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Can (Canine), Mky (Monkey), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SOCS2 / CIS2 antibody

The eight members of the recently identified Suppressor of Cytokines Signalling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signalling in different ways.SOCS2 is capable of inhibiting cytokine signalling by interleukin-6 (IL-6) and growth hormone. SOCS2 interacts with the phosphorylated insulin-like growth factor (IGF-I) receptor, where it may play a regulatory role in cellular growth, differentiation, and inhibition of apoptosis via the Ras and PI3K signalling pathways. In humans, SOCS2 mRNA is expressed widely in both foetal and adult tissues, including foetal kidney and adult heart, skeletal muscle, pancreas, and liver. In rats, SOCS2 mRNA exhibits high levels of expression in liver and heart, and in the mouse nervous system, SOCS2 is expressed exclusively by neurons, where it is switched on developmentally in concordance with neuronal differentiation.Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatal growth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

General readings

Krebs DL & Hilton DJ SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-87 (2001). PubMed PMID: 11553846
Gregorieff A et al. Regulation of SOCS-1 expression by translational repression. J Biol Chem 275:21596-604 (2000). PubMed PMID: 10764816
Krebs DL & Hilton DJ SOCS: physiological suppressors of cytokine signaling. J Cell Sci 113(Pt 16):2813-9 (2000). PubMed PMID: 10910765
Ram PA & Waxman DJ SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem 274:35553-61 (1999). PubMed PMID: 10585430
Yoshimura A The CIS family: negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev 9:197-204 (1998). PubMed PMID: 9918119
Hilton DJ et al. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A 95:114-9 (1998). PubMed PMID: 9419338
Ransome MI & Turnley AM Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2. Neuroscience 132:673-87 (2005). PubMed: 15837129

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOCS2 / CIS2 (C-term) antibody

AP15780PU-N SOCS2 antibody staining of Human Pancreas. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

SOCS2 / CIS2 (C-term) antibody

AP15780PU-N SOCS2 antibody staining of Human Pancreas. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

SOCS2 / CIS2 (C-term) antibody

AP15780PU-N SOCS2 antibody staining of Human Pancreas. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

SOCS2 / CIS2 antibody

ELISA: SOCS2 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOCS2 / CIS2 antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SOCS2 / CIS2 antibody

SOCS2 / CIS2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SOCS2 / CIS2 antibody

SOCS2 / CIS2 Mouse IgG2a 3E7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SOCS2 / CIS2 antibody

SOCS2 / CIS2 Mouse IgG2a 3E7 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

SOCS2 / CIS2 antibody

Immunohistochemical staining of SOCS2 on formalin fixed, paraffin embedded human pancreas with SOCS2 polyclonal antibody. Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

SOCS2 / CIS2 antibody

The tissue lysates derived from mouse liver ( Lane 1 ), mouse muscle ( Lane 2 ) were immunoprobed by SOCS2 polyclonal antibody ( Cat # PAB12779 ) at 1 : 500. An immunoreactive band is observed around ~23kDa. Rabbit Bov, Chk, Hu, Ms, Rt C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

SOCS2 / CIS2 antibody

SOCS2 / CIS2 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

SOCS2 / CIS2 antibody

Western blot analysis of SOCS2 expression in K562 (A); A204 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Mky, Ms, Por, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SOCS2 / CIS2 antibody

Western blot analysis of SOCS2 expression in K562 (A); A204 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Mky, Ms, Por, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SOCS2 / CIS2 antibody

Western blot analysis of SOCS2 expression in K562 (A); A204 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Mky, Ms, Por, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SOCS2 / CIS2 antibody

ELISA: SOCS2 Antibody [29920002] Rabbit Hu E
50 µg / €440.00
  Novus Biologicals Inc.

SOCS2 / CIS2 antibody

SOCS2 / CIS2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €360.00
  Novus Biologicals Inc.

SOCS2 / CIS2 antibody

Immunofluorescence: SOCS2 Antibody (EPR2588(2)) [NBP1-95516] HeLa cells using anti-SOCS2. Rabbit EPR2588(2) Purified Hu ICC/IF, IP, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SOCS2 / CIS2

SOCS2 / CIS2 Human
2 µg / €300.00
  Abnova Taiwan Corp.

18 Item(s)

per page
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