SOCS4 antibody

Principal name

SOCS4 antibody

Alternative names for SOCS4 antibody

Suppressor of cytokine signaling 4, SOCS-4, SOCS7, Suppressor of cytokine signaling 7, SOCS-7

SwissProt ID

Q0VC91 (Bovin), Q8WXH5 (Human), Q91ZA6 (Mouse)

Gene ID

122809 (SOCS4)

Available reactivities

Hu (Human), Bov (Bovine), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of SOCS4 antibody

Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). Currently, there are eight members of the SOCS family that have been recognized, SOCS-1, -2, -3, -4, - 5, -6, -7 and CIS. Structurally, the SOCS proteins are composed of an N-terminus region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminus motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STATinduced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. Within the SOCS subfamily, SOCS-4, SOCS-5, SOCS-6, SOCS-7 remain poorly understood (6). On the basis of structural considerations, it would be expected that SOCS-4, -5, -6, and -7, like SOCS-1, SOCS-2, SOCS-3 and CIS, act to negatively regulate signal transduction (4), but it is uncertain which specific cytokine is involved (7-9).

General readings

1. Gregorieff A. et al. J. Biol. Chem. 275(28), 21596(2000).
2. Krebs DL. et al. J. Cell Sci. 113, 2813(2000).
3. Ram PA. et al. J. Biol. Chem. 274(50), 35553(1999).
4. Hilton DJ. et al. Proc. Natl. Acad. Sci USA 95, 114(1998).
5. Yoshimura A. el al. Cytokine Growth Factor Rev 9, 197(1998).
6. Krebs DL. et al. Stem Cells 19, 378(2001)
7. Masuhara M. et al. Biochem Biophys Res Commun
239(2), 439(1997).
8. Minamoto S. et al. Biochem Biophys Res Commun 237, 79(1997).
9. Cohney SJ. et al. Mol. Cell Biol. 19, 4980(1999).
10. Davey HW. et al. Mol. Cwll Endocrinol 158, 111(1999).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOCS4 antibody

  Rabbit polyclonal antibody to SOCS4 (suppressor of cytokine signaling 4)  
Sample(30 ug of whole cell lysate). A:HeLa S3. 12% SDS PAGE. TA308763 diluted at 1:200 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS4 antibody

  Rabbit polyclonal SOCS4 Antibody (Center)  
Western blot analysis of lysate from MCF-7 cell line,using SOCS4 Antibody (Center)(Cat. #TA324438).TA324438 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane. Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

SOCS4 (C-term) antibody

SOCS4 antibody Cat.-No AP07230PU-N staining of Formalin-Fixed Paraffin-Embedded Human Adrenal at 10 µg/ml after heat-induced antigen retrieval. Rabbit Aff - Purified Hu IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SOCS4 (C-term) antibody

SOCS4 antibody Cat.-No AP15982PU-N staining of paraffin embedded Human Pancreas at3.8 μg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Hu, Por E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SOCS4 - human gene knockout kit via CRISPR

SOCS4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SOCS4 - human gene knockout kit via CRISPR

SOCS4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SOCS4 - human gene knockout kit via CRISPR

SOCS4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SOCS4 - human gene knockout kit via CRISPR

SOCS4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SOCS4 (full length, N-term HIS tag, transcript variant 1)

  Purified recombinant protein of Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
SOCS4 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

SOCS4 (full length, N-term HIS tag, transcript variant 2)

  Purified recombinant protein of Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug  
SOCS4 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SOCS4 (mGFP-tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SOCS4 (mGFP-tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SOCS4 (mGFP-tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SOCS4 (mGFP-tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SOCS4 (Myc-DDK tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SOCS4 (Myc-DDK tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, SOCS4 (Myc-DDK tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SOCS4 (Myc-DDK tagged) - Human suppressor of cytokine signaling 4 (SOCS4), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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