SOCS6 / CIS4 antibody

Principal name

SOCS6 / CIS4 antibody

Alternative names for SOCS6 / CIS4 antibody

Suppressor of cytokine signaling 6, SOCS-6, CIS-4, SOCS-4, SOCS4, Cytokine-inducible SH2 protein 4, Suppressor of cytokine signaling 4

SwissProt ID

O14544 (Human), Q9JLY0 (Mouse)

Gene ID

9306 (SOCS6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP)

Background of SOCS6 / CIS4 antibody

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOCS6 / CIS4 antibody

  Anti-SOCS6 rabbit polyclonal antibody  
Predicted band size: 60kDa. Positive control: jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate :40 ug Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 second) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS6 / CIS4 antibody

  Anti-SOCS6 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human colon and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using SOCS6 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS6 / CIS4 antibody

  Rabbit Polyclonal anti-SOCS-6 Antibody  
Human Placenta stained with anti-SOCS-6 antibody. Rabbit Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SOCS6 - human gene knockout kit via CRISPR

SOCS6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SOCS6 - human gene knockout kit via CRISPR

SOCS6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SOCS6 - human gene knockout kit via CRISPR

SOCS6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SOCS6 - human gene knockout kit via CRISPR

SOCS6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SOCS6 / CIS4 (full length, N-term HIS tag)

  Recombinant protein of human suppressor of cytokine signaling 6 (SOCS6), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
SOCS6 / CIS4 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SOCS6 (mGFP-tagged) - Human suppressor of cytokine signaling 6 (SOCS6), 200 uL, >10^7 TU/mL

Lenti ORF particles, SOCS6 (mGFP-tagged) - Human suppressor of cytokine signaling 6 (SOCS6), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SOCS6 (Myc-DDK tagged) - Human suppressor of cytokine signaling 6 (SOCS6) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SOCS6 (Myc-DDK tagged) - Human suppressor of cytokine signaling 6 (SOCS6) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

10 Item(s)

per page
  • LinkedIn