SOCS6 / CIS4 antibody

Principal name

SOCS6 / CIS4 antibody

Alternative names for SOCS6 / CIS4 antibody

Suppressor of cytokine signaling 6, SOCS-6, CIS-4, SOCS-4, SOCS4, Cytokine-inducible SH2 protein 4, Suppressor of cytokine signaling 4

SwissProt ID

O14544 (Human), Q9JLY0 (Mouse)

Gene ID

9306 (SOCS6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of SOCS6 / CIS4 antibody

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOCS6 / CIS4 (C-term) antibody

AP15782PU SOCS6 antibody staining of Human Placenta. Rabbit Purified Hu, Ms P
0.5 ml / €360.00
  Acris Antibodies GmbH

SOCS6 / CIS4 (C-term) antibody

AP15782PU SOCS6 antibody staining of Human Placenta. Rabbit Purified Hu, Ms P
1 ml / €520.00
  Acris Antibodies GmbH

SOCS6 / CIS4 (C-term) antibody

AP15782PU SOCS6 antibody staining of Human Placenta. Rabbit Purified Hu, Ms P
0.1 ml / €190.00
  Acris Antibodies GmbH

SOCS6 / CIS4 antibody

Predicted band size: 60kDa. Positive control: jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate :40 ug Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 second) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS6 / CIS4 antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using SOCS6 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOCS6 / CIS4 antibody

SOCS6 / CIS4 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

SOCS6 / CIS4 antibody

Western Blot analysis of SOCS6 expression in transfected 293T cell line (H00009306-T01) by SOCS6 MaxPab polyclonal antibody.

Lane 1: SOCS6 transfected lysate(58.85 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SOCS6 / CIS4 antibody

SOCS6 / CIS4 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

SOCS6 / CIS4 antibody

SOCS6 MaxPab rabbit polyclonal antibody. Western Blot analysis of SOCS6 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SOCS6 / CIS4 antibody

Detection limit for recombinant GST tagged SOCS6 is approximately 1ng/ml as a capture antibody. Mouse IgG2a M2-F12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SOCS6 / CIS4 antibody

Immunohistochemical staining of SOCS6 on formalin fixed, paraffin embedded human placenta with SOCS6 polyclonal antibody. Rabbit Hu P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

SOCS6 / CIS4 antibody

SOCS6 / CIS4 Rabbit IgG Hu, Ms P
7 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SOCS6 / CIS4 (full length, N-term HIS tag)

SOCS6 / CIS4 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

SOCS6 / CIS4

SOCS6 / CIS4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SOCS6 / CIS4

SOCS6 / CIS4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

SOCS6 (Human) IP-WB Antibody Pair

SOCS6 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

SOCS6 (Human) Matched Antibody Pair

SOCS6 (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SOCS6 293T Cell Transient Overexpression Lysate(Denatured)

SOCS6 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

18 Item(s)

per page
  • LinkedIn