Somatotropin / Growth Hormone / GH1 antibody

Principal name

Somatotropin / Growth Hormone / GH1 antibody

Alternative names for Somatotropin / Growth Hormone / GH1 antibody

Pituitary growth hormone, Growth hormone 1, HGH

SwissProt ID

P01241 (Human), P01244 (Rat), P01245 (Horse), P01246 (Bovin), P01248 (Pig), P06880 (Mouse), P08998 (Chick), P46404 (Felca), P46407 (Rabit), P67930 (Sheep), Q9JKM4 (Cavpo)

Gene ID

2688 (GH1), 24391 (Gh1), 280804, 14599 (Gh), 443329 (GH), 378781

Available reactivities

Hu (Human), Por (Porcine), Rt (Rat), Bov (Bovine), Can (Canine), Fe (Feline), Sh (Sheep), Ms (Mouse), Mky (Monkey)

Available hosts

Mouse, Rabbit, Chicken, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Radioimmunoassay (R), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Dot blot (Dot), Functional assay (FN), Immunoprecipitation (IP), Neutralisation (NEUT)

Background of Somatotropin / Growth Hormone / GH1 antibody

The peptide hormones of the anterior pituitary are essential for growth, reproduction and intermediary metabolism. Their synthesis and secretion is controlled by hormones of hypothalamic origin, diseases and several pharmacological agents. In vertebrates 10 anterior pituitary hormones have been identified and are classified in to three classes based on their structural features. The growth hormone (GH), prolactin (Prl) and placental lactogen (PL) are members of somototropic hormone family. The glycoprotein hormone family comprise of Thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH). The corticotrophin (ACTH), two melanocyte stimulating hormones (MSH) and the two lipotropins (LPH) are the members of hormones derived from POMC gene. The human growth hormone (hGH) is coded by one gene of a five gene cluster located on chromosome 17, the other genes code for two other variants of lactogen or a growth hormone variant expressed in placenta. The hGH is a single polypeptide chain with 191 amino acids (22 kDa). The hGH has 2 disulfide bonds and it is not glycosylated. There exist a splice variant of hGH where amino acids 32-46 is not translated and this splice variant accounts up to 5-10% of the total hGH. Placenta also secrete a 22 kDa hGH that can be distinguished from the pituitary form but its significance is not clear. The amount of GH secreted in 24 hours is high in children reaches maximal levels at the time of adolescence then tapers off during adult hood. The secretion of GH is in pulses and occurs at irregular intervals. The amplitude of GH concentration is maximum at night shortly after onset of REM sleep. Somatotrophs in anterior pituitary have an intracellular Ca+2 oscillations that are believed to to be responsible for pulsatile secretion of GH (1). The release of GH is under direct control of GH release hormone (GHRH) which stimulates GH. Both GH and GHRH bind to their cognate GPCR leading to an increase (GHRH) or decrease (somatotropin) in cAMP and calcium levels. Several pharmacological agents can increase GH release via acting on hypothalamus.
The physiological effects of GH is via its interaction with cell surface receptor which are widely distributed throughout body. The GH receptor is a 620 amino acid single trans-membrane protein with large extracellular N-terminal domain that interacts with GH and a about 250 amino acid cytoplasmic end of the protein. The large extracellular domain of GH receptor is cleaved to acts as GH binding protein of about 60kDa. The GH has direct effect on lipid and carbohydrate metabolism, its anabolic growth promoting effects are mediated by somatomedins or insulin like growth factors (IGF-1 and IGF-2) which share significant homology (2). GH administration increase the production of IGF in liver, triglyceride hydrolysis and hepatic glucose output. IGF-1 also exerts indirect growth promoting effects of GH by increase chondrogenesis, skeletal and soft tissue growth.

General readings

Bubenik GA, Schams D, White RG, Rowell J, Blake J, Bartos L. Seasonal levels of metabolic hormones and substrates in male and female reindeer (Rangifer tarandus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998;120(2):307-315.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Somatotropin / Growth Hormone + HRP antibody

Somatotropin / Growth Hormone + HRP Mouse GH-Px-2 Aff - Purified Hu ICC/IF, P
0.1 mg / €190.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Human anterior pituitary stained with Anti-hGH antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Human anterior pituitary stained with Anti-hGH antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Human anterior pituitary stained with Anti-hGH antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Immunohistochemistry staining of Paraffin Pituitary tissue by GH antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €290.00
  OriGene Technologies, Inc.

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 090-12610 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 090-11212 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 090-12210 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 090-12610 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 090-10154 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 YC8 Biotin Hu E
0.1 ml / €420.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 YC8 HRP Hu E
0.2 ml / €420.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Mouse IgG1 GA-8 Purified Hu P
0.1 mg / €340.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Rabbit Purified Rt C, WB
50 µl / €490.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Rabbit Serum Bov C, E, R, WB
0.1 ml / €530.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Rabbit Serum Bov C, E, R, WB
20 µl / €180.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Rabbit Serum Bov C, R, WB
0.1 ml / €500.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Rabbit Serum Bov C, R, WB
20 µl / €180.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Rabbit IgG Purified Can, Fe, Hu, Rt, Sh C, ICC/IF, P, WB
50 µl / €330.00
  Acris Antibodies GmbH

Somatotropin / Growth Hormone / GH1 antibody

Somatotropin / Growth Hormone / GH1 Sheep IgG Serum Hu E, R
0.25 ml / €320.00
  Acris Antibodies GmbH

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