Sortilin-related receptor (SORL1) antibody

Principal name

Sortilin-related receptor (SORL1) antibody

Alternative names for Sortilin-related receptor (SORL1) antibody

SorLA, SorLA-1, LR11, Sorting protein-related receptor containing LDLR class A repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats

SwissProt ID

O88307 (Mouse), Q92673 (Human), Q95209 (Rabit), Q98930 (Chick)

Gene ID

6653 (SORL1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Sortilin-related receptor (SORL1) antibody

Sorting protein-related receptor (SORLA/LR11) is a highly conserved mosaic receptor that is expressed by cells in carious tissues including cell of the collecting ducts in the kidney and in neurons of the CNS and peripheral nervous system. The functional features on SORLA/LR11receptor indicate it serves as a sorting receptor shuttling the plasma membrane, endosomes and the Golgi. The terminal oligo saccharides on the SORLA receptors that are synthesized in kidney and brains are modified with terminal beta 1,4 linked GalNAc-4-SO (1). The SORLA receptor interacts with LDL receptor, a protein of approximately 250kDa called LR11 which contained a cluster of 11 LDL receptor binding repeats, a group of 5 LDL receptor YWTD repeats, a learge hexa repeats of elements found in neuronal cell adhesion molecule and a portion similar to yeast receptor for vacuolar protein sorting called VSP10. The oligo saccharides located on the VSP10doamin are modified with beta 1, 4-linked GalNAc when the VPs10 is expressed in cells along with either of two recently coned protein-specific beta 1-4GalNAc-transferase, galNAcTIII and GalNAcTIV. These highly specific modification on LR11 and VSP10 domains are responsible for SORLA interaction for protein sorting and influence the protein trafficking in cells (1).
SORLA protein in neuronal cells is also identified and recognized as neuronal receptor for amyloid precursor protein (APP) that affect its intracellular transport and processing. The expression of SORLA is decreased in Alzheime’s patients and elevated levels in amyloid-beta peptide in SORLA-deficient mice suggest the importance of this protein sorting receptor in neurodegenerative disorders. The SORLA receptor directly interacts with beta-site APP cleaving enzyme (BACE) and APP and inhibit the BACE-APP complex formation and SORLA carboxy tail construct significantly inhibits APP shedding in a (BACE) dependent manner. It is suggested that SORLA acts as a trafficking receptor that prevents BACE-APP interactions and hence BACE cleavage of APP and genetic variants in SORLA may be important risk factors for late-onset Alzheimer’s disease (2). In transfected experiments about 10% of full length SORLA receptor is expressed on the cell surface capable of mediating endocytosis. The SORLA receptor is regulated by proteolytic cleavage mediated by protease furin at site (50-RRKR-53), the truncated SORLA receptor was found in the late golgi suggesting its interaction with newly synthesized ligands (3).
SORLA is a relatively large protein with 2215amino acids with an approximate molecular weight of 250kDa.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sortilin-related receptor (SORL1) antibody

Immunohistochemical analysis of paraffin-embedded human cerebrum tissues using SORL1 antibody Cat.-No AM06185SU-N with DAB staining. Mouse IgG1 3B6B11 Ascites Hu C, F, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Sortilin-related receptor (SORL1) (C-term) antibody

  Goat Anti-SORL1 / LR11 (C Terminus) Antibody  
TA305805 (0.3ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

Sortilin-related receptor (SORL1) antibody

Western blot analysis using SORL1 antibody  against truncated SORL1 recombinant protein (Lane 1) and SORL1 (aa2159-2214)-hIgGFc transfected CHO-K1 cell lysate (Lane 2). Mouse IgG1 7D7B11 Ascites Hu WB
0.1 ml / €440.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SORL1 (Myc-DDK tagged) - Human sortilin-related receptor, L(DLR class) A repeats containing (SORL1), 200 uL, >10^7 TU/mL

Lenti ORF particles, SORL1 (Myc-DDK tagged) - Human sortilin-related receptor, L(DLR class) A repeats containing (SORL1), 200 uL, >10^7 TU/mL  
200 µl / €2,349.00
  OriGene Technologies, Inc.

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