SOX17 antibody

Principal name

SOX17 antibody

Alternative names for SOX17 antibody

Transcription factor SOX-17, SRY-box 17, FLJ22252

SwissProt ID

Q61473 (Mouse), Q9H6I2 (Human)

Gene ID

64321 (SOX17), 20671 (Sox17)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Ze (Zebrafish), Rt (Rat), Mky (Monkey), Op (Opossum), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Luminex (LMNX)

Background of SOX17 antibody

SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors that play important roles in embryonic development and in the determination of the cell fate. The Sox family of proteins contains a high mobility group (HMG) motif that binds the DNA minor groove and are often used as markers to assess the differentiation of specific cell lineages. Whereas the association of Oct 4 with Sox 2 is associated with pluripotent cell fate, the association of Oct 4 with Sox 17 is associated with endodermal cell fate. The expression pattern of Sox 17 is complex. It is expressed in progenitor cells derived from two different germ layers and activates the transcription of key regulator genes for vasculogenesis, hematopoiesis, and erythrocyte differentiation. Sox 17 plays a key role in endoderm formation, cardiac myogenesis, kidney and urinary development and differentiation of oligodendrocytes. The expression of Sox 17 has been used as a marker of lineage or disease in various studies. The overexpression of Sox 17 is thought to promote tumor progression by promoting tumor angiogenesis and vascular abnormalities. Sox 17 expression is associated with gastric cancer progression, whereas SOX2 and SOX17 expression patterns are thought to be useful for distinguishing between seminoma and embryonal carcinoma. Sox17 was shown to be specifically expressed in fetal and neonatal but not adult HSCs. 
Although Sox 17 was first characterized in embryonal development, it has also been shown to be expressed in some cancers. Our unpublished characterization of the developed antibodies show that the protein is expressed in various types of cancer cell lines and as shown in the previous page, the expression of Sox 17 may be modulated by drugs such as Aphidicolin and Nocadazole that block cells in Go or G2M stage of the cell cycle respectively. That Sox 17 is expressed in the G2M stage of the cell cycle is interesting and warrants further study.

General readings

Schepers,G.E., et al., (2002) Dev. Cell 3 (2), 167-170

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOX17 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-SOX17 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500044) Mouse IgG1 OTI3B10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SOX17 antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-SOX17 mouse monoclonal antibody. (TA500281). Dilution Factor: 1:50; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min. Mouse IgG2b OTI2B6 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SOX17 antibody

SOX17 staining of  endodermal cells derived from human embyronic stem cells. Cells were stained using Rhodamine Red-conjugated donkey anti-goat secondary antibody  and counterstained using Fluoro Nissl (green). Courtesy of Dr. Jong-Hoon Kim and Dr. Ron McKay from the National Institute of Neurological Disorders and Stroke & Stem Cell Unit at NIH. Goat Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €450.00
  Neuromics Antibodies

SOX17 antibody

SOX17 Mouse IgG2b OTI2G8 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SOX17 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-SOX17 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500045) Mouse IgG2b OTI2F9 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SOX17 antibody

Anti-SOX17 mouse monoclonal antibody (TA500046) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOX17(RC220888). Mouse IgG2a OTI3H5 Purified Can, Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SOX17 antibody

SOX17 ELISA with 2F9 Capture (TA600123) and 2G8 Detection (TA700124) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI2F9 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 ELISA with 3H5 Capture (TA600125) and 2G8 Detection (TA700124) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI3H5 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 ELISA with 2G8 Capture (TA600124) and 2F9 Detection (TA700123) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI2F9 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 ELISA with 2F9 Capture (TA600123) and 2G8 Detection (TA700124) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI2G8 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 ELISA with 2F9 Capture (TA600123) and 5G6 Detection (TA700126) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI5G6 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 Antibody Cat.-No AM32707PU-N (Clone BC24-3.5CH) staining of Rh18 and Rh30 Cells after treatment with Aphidicolin which blocks in Go (Upper panels) or Nocadazole which blocks in the G2M of the cell cycle (bottom panels). PE anti-mouse Ig labeled secondary antibody. Mouse IgG1 BC24-3.5CH Purified Can, Hu, Ms C, ICC/IF, WB
0.1 mg / €250.00
  Acris Antibodies GmbH

SOX17 antibody

Immunohistochemistry-Paraffin: SOX17 Antibody (2G8) [NBP1-47996] - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-SOX17 mouse monoclonal antibody. (Dilution 1:50) Mouse IgG2b 2G8 Aff - Purified Can, Hu ICC/IF, P, WB
0.1 ml / €620.00
  Novus Biologicals Inc.

SOX17 antibody

Western Blot: SOX17 Antibody [TA337006] - analysis of SOX17 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using SOX17 antibody at 1 ug/ml. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solut Rabbit Purified Hu, Ms, Op, Prim, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX17 antibody

Western blot analysis of SOX17 in HepG2 cell lysate with SOX17 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX17 antibody

Anti-SOX17 mouse monoclonal antibody (TA500282) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOX17(RC220888). Mouse IgG1 OTI5G6 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SOX17 antibody

SOX17 ELISA with 2G8 Capture (TA600124) and 2F9 Detection (TA700123) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI2G8 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 ELISA with 5G6 Capture (TA600126) and 2F9 Detection (TA700123) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI5G6 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 Luminex with 2G8 Capture (TA600124) and 3H5 Detection (TA700125) Antibodies. Substrate used: Recombinant Human SOX17 (TP320888) Mouse IgG1 OTI3H5 Purified Hu LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

SOX17 antibody

SOX17 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

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