SOX2 antibody

Principal name

SOX2 antibody

Alternative names for SOX2 antibody

Transcription factor SOX-2, ANOP3, MCOPS3, SRY-box 2, SRY-related HMG-box gene 2, SRY (sex determining region Y)-box 2

SwissProt ID

O42569 (Xenla), P48431 (Human), P48432 (Mouse), P54231 (Sheep), Q6P0E1 (Danre)

Gene ID

6657 (SOX2), 20674 (Sox2)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Sh (Sheep), Xen (Xenopus), Bov (Bovine), Por (Porcine), African clawed frog, Fi (Fish), Fe (Feline), Prim (Primate)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot)

Background of SOX2 antibody

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Sox2 and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells.

General readings

Wei Z., et al. (2009) Stem Cells. 27(12):2969-78.
Martinez-Fernandez A., et al. (2009) Circ Res. 25; 105(7):648-56.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOX2 antibody

SRY (sex determining region Y)-box 2 (SOX2)  detected in immersion fixed BG01V human embryonic stem cells cultured on irradiated mouse embryonic fibroblasts  for 3 hours at room temperature (Dilution: 10 µg/mL). Cells were stained using the 493-conjugated Anti-Goat IgG Secondary Antibody (green) and counterstained with DAPI (blue, inset). Goat Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €470.00
  Neuromics Antibodies

SOX2 antibody

  Mouse Monoclonal Antibody against SOX2  
Western blot analysis of SOX2 Antibody (Cat.#TA302025) by SOX2 recombinant protein. SOX2(arrow) was detected using the purified Mab. Mouse IgG1 57CT23.3.4 Purified Hu ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 (N-term) antibody

  Rabbit Polyclonal Antibody against SOX2 (N-term)  
Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35ug/lane). SOX2(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms, Ze F, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Mouse Monoclonal SOX2 Antibody (4G8)  
Western Blot: SOX2 Antibody (4G8) [TA337182] - Western blot detection of SOX2 in A. HEK293 cell lysate B. NCCIT cell lysate and C. Full length recombinant protein. Mouse IgG2b 4G8 Purified Hu C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Monoclonal anti-SOX-2 Antibody  
Western Blot analysis of MCF7 cell lysate with SOX-2 antibody Rabbit SP76 Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal SOX2 Antibody  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-SOX2 rabbit polyclonal antibody. (TA590150) Rabbit IgG Purified Hu, Ms Dot, E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Xenopus laevis cornea epithellium; Researcher:Kim Perry, University of IllinoisApplication:IHCSpecies+tissue/cell type:Xenopus laevis cornea epithelliumPrimary antibody dilution:1:300Secondary antibody:Goat anti-rabbit -rhodamineSecondary antibody dilution:1:300; SOX2 antibody - N-terminal region (ARP31737_P050) in Xenopus laevis cornea epithellium cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

SOX2 antibody

  Rabbit Polyclonal Antibody against SOX2 - Embryonic Stem Cell Marker  
Detection of SOX2 in mouse brain lysate (0.5ug/ml). Rabbit IgG Purified Hu, Ms, Sh F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal SOX2 Antibody  
Western blot analysis of SOX2 in 3T3 cell lysate with SOX2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Anti-SOX2 Goat Polyclonal Antibody  
Anti-SOX2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

SOX2 antibody

  Anti-SOX2 Rabbit Polyclonal Antibody  
Predicted band size: 34 kDa . Positive control: MCF7 cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 45 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Anti-SOX2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human thyroid and ovarian cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using SOX2 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal anti-SOX2 (NH2 terminus) Antibody  
NTERA-2 whole cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal antibody raised against the N-terminal region of SOX2. Proteins were visualized using HRP Donkey anti-rabbit IgG and a chemiluminescence detection system. Rabbit IgG Poly6308 Purified Hu ICC/IF, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit anti-SOX2 Polyclonal Antibody  
Western blot analysis of brain cell lysate using SOX2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal SOX2 Antibody  
Western Blot: SOX2 Antibody [TA336549] - WB analysis of SOX-2 protein in 10ug of normal human brain lysate with SOX-2 antibody TA336549 at a dilution of 1:500 Rabbit Purified Fi, Hu, Ms, Rt C, E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal SOX2 Antibody  
Western Blot: SOX2 Antibody [TA336966] - analysis of SOX2 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used fo Rabbit Purified Chk, Fe, Hu, Ms, Por, Prim P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Mouse Monoclonal Sox2 Antibody  
Western blot detection of Sox2 in F9 cell lysates using Sox2 mouse mAb (1:1000 diluted).Predicted band size:35KDa.Observed band size:35KDa. Mouse IgG1 2A10-F11-F12 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal Anti-SOX2 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: 231 cells, hela cells, Primary antibody: (SOX2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal anti-SOX2 (NH2 terminus) Antibody  
NTERA-2 whole cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal antibody raised against the N-terminal region of SOX2. Proteins were visualized using HRP Donkey anti-rabbit IgG and a chemiluminescence detection system. Rabbit Poly6308 Purified Hu ICC/IF, WB
50 µl / €280.00
  OriGene Technologies, Inc.

SOX2 antibody

  Rabbit Polyclonal anti-SOX2 Antibody  
Western blot analysis of extracts from NF-1 (lane 1) and HepG2 (lane 2) using anti-SOX2 antibody(poly6519). Rabbit Poly6519 Purified Hu ICC/IF, WB
50 µl / €280.00
  OriGene Technologies, Inc.

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