SOX2 antibody

Principal name

SOX2 antibody

Alternative names for SOX2 antibody

Transcription factor SOX-2, ANOP3, MCOPS3, SRY-box 2, SRY-related HMG-box gene 2, SRY (sex determining region Y)-box 2

SwissProt ID

O42569 (Xenla), P48431 (Human), P48432 (Mouse), P54231 (Sheep), Q6P0E1 (Danre)

Gene ID

6657 (SOX2), 378723 (sox2), 20674 (Sox2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Bov (Bovine), Chk (Chicken), Can (Canine), Por (Porcine), African clawed frog, Sh (Sheep), Xen (Xenopus), Eq (Equine), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Gorilla, Fi (Fish), Fe (Feline), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot)

Background of SOX2 antibody

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Sox2 and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells.

General readings

Bylund, M., Andersson, E. Novitch, B. G., Muhr, J. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nature Neurosci. 6: 1162-1168, (2003). Chassaing, N., Gilbert-Dussardier, B., Nicot, F., Fermeaux, V., Encha-Razavi, F., Fiorenza, M., Toutain, A., Calvas, P. Germinal mosaicism and familial recurrence of a SOX2 mutation with highly variable phenotypic expression extending from AEG syndrome to absence of ocular involvement. Am. J. Med. Genet. 143A: 289-291, (2007).

  1. Quick-Filters:
  2. Cited (2)
  3. Highly Validated (8)

Items 1 to 20 of 61 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SOX2 antibody

SRY (sex determining region Y)-box 2 (SOX2)  detected in immersion fixed BG01V human embryonic stem cells cultured on irradiated mouse embryonic fibroblasts  for 3 hours at room temperature (Dilution: 10 µg/mL). Cells were stained using the 493-conjugated Anti-Goat IgG Secondary Antibody (green) and counterstained with DAPI (blue, inset). Goat Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €470.00
  Neuromics Antibodies

SOX2 antibody

Western blot analysis of SOX2 Antibody (Cat.#TA302025) by SOX2 recombinant protein. SOX2(arrow) was detected using the purified Mab. Mouse IgG1 57CT23.3.4 Purified Hu ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 (N-term) antibody

Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35ug/lane). SOX2(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms, Ze F, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Western Blot: SOX2 Antibody (4G8) [TA337182] - Western blot detection of SOX2 in A. HEK293 cell lysate B. NCCIT cell lysate and C. Full length recombinant protein. Mouse IgG2b 4G8 Purified Hu C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-SOX2 rabbit polyclonal antibody. (TA590150) Rabbit IgG Purified Hu, Ms Dot, E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Xenopus laevis cornea epithellium; Researcher:Kim Perry, University of IllinoisApplication:IHCSpecies+tissue/cell type:Xenopus laevis cornea epithelliumPrimary antibody dilution:1:300Secondary antibody:Goat anti-rabbit -rhodamineSecondary antibody dilution:1:300; SOX2 antibody - N-terminal region (ARP31737_P050) in Xenopus laevis cornea epithellium cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

SOX2 antibody

Western Blot: SOX2 Antibody [29930002] - Cell lysate from 293 over expressing Sox2 was subjected to SDS-PAGE and transfer to nitrocellulose membrane. The membrane was incubated with anti-Sox2 antibody (1:1000 dilution) and then probed anti-rabbit IgG-HRP.  Signals were acquired with a CCD camera. Arrow points to Sox2.  Data courtesy of a SDI customer. Rabbit Hu E
50 µg / €440.00
  Novus Biologicals Inc.

SOX2 antibody

Immunohistochemistry: SOX2 Antibody (EPR3131) [NBP1-40712] - Immunohistochemical analysis of paraffin-embedded human adult brain tissue using anti-SOX2 Rabbit IgG EPR3131 Hu, Ms ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

SOX2 antibody

Immunohistochemistry: SOX2 Antibody (EPR3130) [NBP1-40720] - Immunohistochemical analysis of paraffin-embedded fetal brain tissue using anti-SOX2 Rabbit IgG EPR3130 Hu IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

SOX2 (N-term) antibody

AM09112PU SOX2 antibody staining of Human newborn brain. Rabbit IgG SP76 Purified Hu P, WB
0.5 ml / €510.00
  Acris Antibodies GmbH

SOX2 (N-term) antibody

AM09112PU SOX2 antibody staining of Human newborn brain. Rabbit IgG SP76 Purified Hu P, WB
1 ml / €730.00
  Acris Antibodies GmbH

SOX2 (N-term) antibody

AM09112PU SOX2 antibody staining of Human newborn brain. Rabbit IgG SP76 Purified Hu P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

SOX2 (N-term) antibody

Human skin stained with anti-SOX2 antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

SOX2 (N-term) antibody

Human skin stained with anti-SOX2 antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

SOX2 (N-term) antibody

Human skin stained with anti-SOX2 antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

SOX2 antibody

Detection of SOX2 in mouse brain lysate (0.5ug/ml). Rabbit IgG Purified Hu, Ms, Sh F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Western blot analysis of SOX2 in 3T3 cell lysate with SOX2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Anti-SOX2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

SOX2 antibody

Predicted band size: 34 kDa . Positive control: MCF7 cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 45 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SOX2 antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid and ovarian cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using SOX2 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Items 1 to 20 of 61 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  • LinkedIn