SP3 / SPR-2 antibody

Principal name

SP3 / SPR-2 antibody

Alternative names for SP3 / SPR-2 antibody

Transcription factor Sp3

SwissProt ID

O70494 (Mouse), Q02447 (Human), Q90WR8 (Chick)

Gene ID

6670 (SP3), 20687 (Sp3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of SP3 / SPR-2 antibody

The Sp (specificity protein) family is a family of transcription factors that bind to cis-elements in the promoter regions of various genes. Members of the family bind with varying affinities to sequences designated as 'Sp1 sites' (e.g., GC-boxes, CACCC-boxes, and basic transcription elements) (4,8). In human cells, telomerase activity is tightly regulated by the expression of human telomerase reverse transcriptase (hTERT). Sp1 and Sp3 have been shown to associate with the hTERT promoter, recruiting histone deacetylase for the localized deacetylation of nucleosomal histones and transcriptional silencing of the hTERT gene in normal human somatic cells (3). The role of the Sp family members in many diseases is being investigated. Sp-1 has been discussed in association with diabetic microvasculopathy and Huntington's disease (2,5). It has been suggested that transcription of the Sp3 gene is blocked in immune cells from most patients with multiple sclerosis and that this contributes to the development of central nervous system inflammation in the disease (6). Sp3 has also been shown to be required for proper skeletal ossification (7). Down-regulation of the transcription factor Sp-1 is thought to be involved in the inhibition of strain-induced mitogenesis in human vascular smooth muscle cells by estrogen via an estrogen receptor mediated process (1).

General readings

Whitten,C., Gene 413 (1-2), 58-66 (2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SP3/4 antibody

Immunohistochemistry (IHC) analysis of Sp3/4 antibody (Cat.-No.: AP06710PU-N) on paraffin-embedded sections. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SP3/4 antibody

Immunofluorescent analysis of SP3/4 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Chk, Hu, Ms, Ze ICC/IF, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SP3/4 antibody

Immunofluorescent analysis of SP3/4 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Chk, Hu, Ms, Ze ICC/IF, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SP3/4 antibody

Immunofluorescent analysis of SP3/4 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Chk, Hu, Ms, Ze ICC/IF, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SP3 / SPR-2 antibody

Western blot analysis of extracts from Jurkat cells, using SP3/4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SP3 / SPR-2 antibody

Western blot analysis of Sp3 using lysates from Jurkat cells (Lane 1& 2), 3T3 cells (Lane 3) and Rat kidney (Lane 4). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SP3 / SPR-2 antibody

Staining of mouse bone marrow with Anti-Mouse CD202b (TIE2) PE and Anti-Mouse Ly-6A/E (Sca-1) APC + Anti-Mouse CD117 (c-Kit) APC (cat 17-1171).  Total viable lineage negative cells were used for analysis. Rat TEK4 Purified Ms F, P
50 µg / €120.00
  OriGene Technologies, Inc.

SP3 / SPR-2 antibody

WB Suggested Anti-SP3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SP3 / SPR-2 (C-term) antibody

Formalin-Fixed Paraffin-Embedded Human tonsil tissue was stained with SP3 Antibody Cat.-No AP33176PU and developed with an alkaline phosphatase chromogen substate (red color). Tissue was counterstained with H&E (blue/pink). Magnification, 40X. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €390.00
  Acris Antibodies GmbH

SP3 / SPR-2 (C-term) antibody

Formalin-Fixed Paraffin-Embedded Human tonsil tissue was stained with SP3 Antibody Cat.-No AP33176PU and developed with an alkaline phosphatase chromogen substate (red color). Tissue was counterstained with H&E (blue/pink). Magnification, 40X. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µl / €230.00
  Acris Antibodies GmbH

SP3 / SPR-2 antibody

SP3 / SPR-2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 / SPR-2 Mouse IgG2a 3D4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 monoclonal antibody (M07), clone 2E5 Western Blot analysis of SP3 expression in A-549 ( Cat # L025V1 ). Mouse IgG2a 2E5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 monoclonal antibody (M08), clone 2F6. Western Blot analysis of SP3 expression in human stomach. Mouse IgG2a 2F6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 monoclonal antibody (M09), clone 4E5. Western Blot analysis of SP3 expression in human stomach. Mouse IgG2a 4E5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 / SPR-2 Mouse IgG2a 2E8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 / SPR-2 Mouse IgG2a 2D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 monoclonal antibody (M12), clone 3G5. Western Blot analysis of SP3 expression in human stomach. Mouse IgG2a 3G5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 monoclonal antibody (M13), clone 1D3. Western Blot analysis of SP3 expression in human Intestinal wall. Mouse IgG2a 1D3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SP3 / SPR-2 antibody

SP3 / SPR-2 Mouse IgG2a 4B4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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