SP8 antibody

Principal name

SP8 antibody

Alternative names for SP8 antibody

Transcription factor Sp8

SwissProt ID

Q8BMJ8 (Mouse), Q8IXZ3 (Human)

Gene ID

221833 (SP8)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB)

Background of SP8 antibody

Sp8 is a member of the zinc finger transcription factor family. It is expressed during embryogenesis in the forming apical ectodermal ridge (AER), restricted regions of the central nervous system, and tail bud. Targeted deletion of the Sp8 gene gives a striking phenotype, with severe truncation of both forelimbs and hindlimbs, absent tail, as well as defects in anterior and posterior neuropore closure leading to exencephaly and spina bifida. 
Outgrowth of the limb depends on formation of the AER, a signaling center that forms at the limb bud apex. In Sp8 mutants, the AER precursor cells are induced and initially express multiple appropriate marker genes, but expression of these genes is not maintained and progression to a mature AER is blocked. These observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates AER formation. {Bell, et al (2003) "Sp8 is crucial for limb outgrowth and neuropore closure" PNAS, 100(21):12197.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SP8 (C-term) antibody

Western blot analysis of SP8 Antibody (C-term) Cat.-No AP53993PU-N in Mouse heart tissue lysates (35ug/lane).This demonstrates the SP8 antibody detected the SP8 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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