SPAM1 antibody

Principal name

SPAM1 antibody

Alternative names for SPAM1 antibody

Sperm adhesion molecule 1, Hyaluronidase PH-20, Hyal-PH20, PH20, HYAL3

SwissProt ID

P23613 (Cavpo), P38566 (Rabit), P38567 (Human), P48794 (Mouse), Q62803 (Rat)

Gene ID

6677 (SPAM1), 20690 (Spam1), 117037

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of SPAM1 antibody

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctiol protein is a hyaluronidase that ebles sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell sigling, and a receptor that is involved in sperm-zo pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SPAM1 antibody

  Rabbit anti-SPAM1 Polyclonal Antibody  
Western blot analysis of extracts of PC-3 cell lines , using SPAM1 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPAM1 antibody

  Rabbit Polyclonal Anti-SPAM1 Antibody  
WB Suggested Anti-SPAM1 Antibody; Titration: 1.0 ug/ml; Positive Control: Jurkat Whole Cell Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SPAM1 - human gene knockout kit via CRISPR

SPAM1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPAM1 - human gene knockout kit via CRISPR

SPAM1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPAM1 - human gene knockout kit via CRISPR

SPAM1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPAM1 - human gene knockout kit via CRISPR

SPAM1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spam1 - mouse gene knockout kit via CRISPR

Spam1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Spam1 - mouse gene knockout kit via CRISPR

Spam1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spam1 - mouse gene knockout kit via CRISPR

Spam1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spam1 - mouse gene knockout kit via CRISPR

Spam1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SPAM1 (transcript variant 1)

  Recombinant protein of human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 1  
SPAM1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (mGFP-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPAM1 (Myc-DDK-tagged)-Human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Spam1 (GFP-tagged) - Mouse sperm adhesion molecule 1 (Spam1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Spam1 (GFP-tagged) - Mouse sperm adhesion molecule 1 (Spam1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

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