Spatacsin antibody

Principal name

Spatacsin antibody

Alternative names for Spatacsin antibody

SPG11, KIAA1840, Spastic paraplegia 11 protein, FLJ21439, Colorectal carcinoma-associated protein

SwissProt ID

Q3UHA3 (Mouse), Q96JI7 (Human)

Gene ID

80208 (SPG11)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Spatacsin antibody

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon D damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene. Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Spatacsin antibody

  Rabbit Polyclonal SPG11 Antibody  
Western blot analysis of SPG11 in mouse heart tissue lysate with SPG11 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SPG11 - human gene knockout kit via CRISPR

SPG11 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPG11 - human gene knockout kit via CRISPR

SPG11 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPG11 - human gene knockout kit via CRISPR

SPG11 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPG11 - human gene knockout kit via CRISPR

SPG11 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SPG11 (Myc-DDK tagged) - Human spastic paraplegia 11 (autosomal recessive) (SPG11), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPG11 (Myc-DDK tagged) - Human spastic paraplegia 11 (autosomal recessive) (SPG11), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

6 Item(s)

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