Spectrin alpha chain (brain) / SPTAN1 antibody

Principal name

Spectrin alpha chain (brain) / SPTAN1 antibody

Alternative names for Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin non-erythroid alpha chain, Alpha-II spectrin, Fodrin alpha chain, SPTA2

SwissProt ID

P07751 (Chick), P16086 (Rat), P16546 (Mouse), Q13813 (Human), Q9P0V0 (Human)

Gene ID

6709 (SPTAN1), 374234

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Dros (Drosophila), Ze (Zebrafish), GP (Guinea Pig), Mam (Mammalia), Por (Porcine), Rb (Rabbit), Eq (Equine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ChIP assay (ChIP), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of Spectrin alpha chain (brain) / SPTAN1 antibody

Alpha Fodrin (SPTAN1; also called non-erythroid alpha spectrin) belongs to spectrin family of proteins which are widely distributed filamentous proteins implicated in generating a supporting/organizing scaffold for cell membranes, and SPTAN1 protein is involved in processes such as secretion, interactions with calmodulin in Ca2+ dependent manner and Ca2+ dependent cytoskeletal movements at the membranes. SPTAN1 interacts with several proteins including ACP1, CALM, EMD, TRPC4 etc. and forms a component of a complex that contains several other proteins such as ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. SPTAN1 cleavage accompanies apoptosis, induced by activation via CD3/TCR complex, Fas/CD95 ligation and other Fas-expressing cells or through cellular exposure to staurosporine, dexamethasone, synthetic ceramide etc. Major products of SPTAN1 cleavage are N-termil/C-termil fragments, and phosphorylation of Tyr-1176 has been shown to decrease its sensitivity to cleavage by calpain in vitro. Defects in SPTAN1 have been linked to EIEE5 (epileptic encephalopathy early infantile type 5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Spectrin alpha chain (brain) / SPTAN1 antibody

  Rabbit polyclonal SPTA2 (Cleaved-Asp1185) antibody  
Western blot analysis of extracts from HeLa cells and A549 cells, all treated with etoposide (25uM, 24hours), using SPTA2 (Cleaved-Asp1185) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Rabbit Polyclonal Alpha Fodrin Antibody  
Western Blot: Alpha Fodrin Antibody [TA336859] - Western blot of mouse sciatic nerve extract (lanes 1 and 2) and brain homogenate (3). A prominent band running at 240kDa represents the intact Alpha Fodrin heavy chain. More minor bands below this likely re Rabbit Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Rabbit Polyclonal Anti-SPTAN1 Antibody - N-terminal region  
WB Suggested Anti-SPTAN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Hela cell lysateSPTAN1 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells Rabbit IgG Purified Bov, Eq, Hu, Por, Rb, Rt IP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Rabbit Polyclonal Anti-SPTAN1 Antibody  
Spectrin alpha chain (brain) / SPTAN1 Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Mouse Monoclonal anti-Alpha-I Spectrin Antibody  
Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 17C7 Purified Hu E, ICC/IF, P, WB
200 µl / €479.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Mouse Monoclonal anti-Alpha-II Spectrin Antibody  
Western blot showing alpha;-II spectrin (D8B7) specificity. Lane 1: Hela cell lysate; Lane 2: Mouse cerebellum; Lane 3: NIH/3T3 cell lysate: Lane 4: BSA negative control. Mouse IgG2b D8B7 Purified Hu E, ICC/IF, P, WB
200 µl / €479.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Mouse Monoclonal anti-a-Spectrin (SPTAN1) Antibody  
Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 8B8D10F11 Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Mouse Monoclonal anti-a-Spectrin (SPTAN1) Antibody  
Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 2A5A7H8 Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

  Mouse Monoclonal anti-a-Spectrin (SPTAN1) Antibody  
Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 1C2B10C3C11 Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 AA6 Ig Fraction Hu C, E, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and DNA (blue). Mouse IgG1 3D7 Aff - Purified Bov, Hu, Rt ICC/IF, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Western blot analysis of α-Fodrin in HeLa cell extract. Rabbit IgG Aff - Purified Chk, Hu, Ms, Rt P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and Nestin (red). Rabbit Serum Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 7A3 (AA6) Purified Chk, GP, Hu, Mam, Ms, Por, Rb, Rt ChIP, ICC/IF, IP, WB
50 µg / €850.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 (cleaved) antibody

Western blot analysis of extracts from HeLa/A549 cells, treated with etoposide 25uM 24H, using SPTA2 (Cleaved-Asp1185) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

Spectrin alpha chain (brain) / SPTAN1 (cleaved) antibody

Western blot analysis of extracts from HeLa/A549 cells, treated with etoposide 25uM 24H, using SPTA2 (Cleaved-Asp1185) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

Spectrin alpha chain (brain) / SPTAN1 (676-1043) antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

SPTAN1 - human gene knockout kit via CRISPR

SPTAN1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPTAN1 - human gene knockout kit via CRISPR

SPTAN1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPTAN1 - human gene knockout kit via CRISPR

SPTAN1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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