Spectrin alpha chain (brain) / SPTAN1 antibody

Principal name

Spectrin alpha chain (brain) / SPTAN1 antibody

Alternative names for Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin non-erythroid alpha chain, Alpha-II spectrin, Fodrin alpha chain, SPTA2

SwissProt ID

P07751 (Chick), P16086 (Rat), P16546 (Mouse), Q13813 (Human), Q9P0V0 (Human)

Gene ID

6709 (SPTAN1), 374234

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), GP (Guinea Pig), Mam (Mammalia), Por (Porcine), Rb (Rabbit), Bov (Bovine), Can (Canine), Dros (Drosophila), Ze (Zebrafish), Eq (Equine)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ChIP assay (ChIP)

Background of Spectrin alpha chain (brain) / SPTAN1 antibody

Alpha Fodrin (SPTAN1; also called non-erythroid alpha spectrin) belongs to spectrin family of proteins which are widely distributed filamentous proteins implicated in generating a supporting/organizing scaffold for cell membranes, and SPTAN1 protein is involved in processes such as secretion, interactions with calmodulin in Ca2+ dependent manner and Ca2+ dependent cytoskeletal movements at the membranes. SPTAN1 interacts with several proteins including ACP1, CALM, EMD, TRPC4 etc. and forms a component of a complex that contains several other proteins such as ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. SPTAN1 cleavage accompanies apoptosis, induced by activation via CD3/TCR complex, Fas/CD95 ligation and other Fas-expressing cells or through cellular exposure to staurosporine, dexamethasone, synthetic ceramide etc. Major products of SPTAN1 cleavage are N-termil/C-termil fragments, and phosphorylation of Tyr-1176 has been shown to decrease its sensitivity to cleavage by calpain in vitro. Defects in SPTAN1 have been linked to EIEE5 (epileptic encephalopathy early infantile type 5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Spectrin alpha chain (brain) / SPTAN1 antibody

Western Blot: SPTAN1/Alpha II-Spectrin Antibody [NB100-60441] - Detection of Human and Mouse SPTAN1/Alpha II-Spectrin by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg), 293T (T; 50 mcg), and mouse NIH3T3 (M; 50 mcg) cells. Antibody: Affinity purified rabbit anti- SPTAN1/Alpha II-Spectrin antibody for WB at 0.1 mcg/ml Detection: Chemiluminescence with an exposure time of 30 seconds. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €380.00
  Novus Biologicals Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

Western blot analysis of extracts from HeLa cells and A549 cells, all treated with etoposide (25uM, 24hours), using SPTA2 (Cleaved-Asp1185) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

Western Blot: Alpha Fodrin Antibody [TA336859] - Western blot of mouse sciatic nerve extract (lanes 1 and 2) and brain homogenate (3). A prominent band running at 240kDa represents the intact Alpha Fodrin heavy chain. More minor bands below this likely re Rabbit Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

WB Suggested Anti-SPTAN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Hela cell lysateSPTAN1 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells Rabbit IgG Purified Bov, Eq, Hu, Por, Rb, Rt IP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 AA6 Ig Fraction Hu C, E, WB
0.1 mg / €470.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and DNA (blue). Mouse IgG1 3D7 Aff - Purified Bov, Hu, Rt ICC/IF, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Western blot analysis of α-Fodrin in HeLa cell extract. Rabbit IgG Aff - Purified Chk, Hu, Ms, Rt P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and Nestin (red). Rabbit Serum Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 7A3 (AA6) Purified Chk, GP, Hu, Mam, Ms, Por, Rb, Rt ChIP, ICC/IF, IP, WB
50 µg / €850.00
  Acris Antibodies GmbH

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 AA6 Chk C, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG2b D8B7 Hu, Ms, Rt C, E, ICC/IF, WB
0.2 ml / €1,170.00
  Abnova Taiwan Corp.

Spectrin alpha chain (brain) / SPTAN1 antibody

Western blot analysis of Spna2 expression in HeLa cell lysate. Rabbit Chk, Hu, Ms, Rt C, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Spectrin alpha chain (brain) / SPTAN1 (cleaved) antibody

Western blot analysis of extracts from HeLa/A549 cells, treated with etoposide 25uM 24H, using SPTA2 (Cleaved-Asp1185) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

Spectrin alpha chain (brain) / SPTAN1 (cleaved) antibody

Western blot analysis of extracts from HeLa/A549 cells, treated with etoposide 25uM 24H, using SPTA2 (Cleaved-Asp1185) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

Spectrin alpha chain (brain) / SPTAN1 antibody

Human NT-2, mouse brain,rat brain; Immunohistochemistry with NT-2 cell line, mouse brain, and rat brain tissue; SPTAN1 antibody - N-terminal region (ARP58532_P050) in Human NT-2, mouse brain,rat brain cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Dros, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Spectrin alpha chain (brain) / SPTAN1 (676-1043) antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Neuromics Antibodies

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Rabbit IgG Serum Chk ICC/IF, WB
0.2 ml / €340.00
  Novus Biologicals Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

Spectrin alpha chain (brain) / SPTAN1 Mouse IgG1 AA6 Hu, Rt C, P, WB
50 µg / €400.00
  Novus Biologicals Inc.

Spectrin alpha chain (brain) / SPTAN1 antibody

Western Blot: Alpha Fodrin Antibody [NBP1-53093] - This Anti-SPTAN1 antibody was used in Western Blot of Hela tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Spectrin alpha chain (brain) / SPTAN1 (transcript variant 2)

Spectrin alpha chain (brain) / SPTAN1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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