Spectrin beta chain (erythrocyte) / SPTB antibody

Principal name

Spectrin beta chain (erythrocyte) / SPTB antibody

Alternative names for Spectrin beta chain (erythrocyte) / SPTB antibody

Beta-I spectrin, SPTB1

SwissProt ID

P11277 (Human), P15508 (Mouse)

Gene ID

6710 (SPTB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Spectrin beta chain (erythrocyte) / SPTB antibody

Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. It is associated with the cytoplasmic surface of the membrane by attachment to ankyrin, a peripheral membrane protein. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol. On SDS PAGE gels erythrocyte spectrin appears as two bands referred to as alpha (240 kDa) and beta (220 kDa). While the simplest form of spectrin in solution is an alpha-beta heterodimer, spectrin can undergo self-association in various conditions to form a tetramer of alpha2-beta2. In recent years a large number of spectrin-like molecules have been found in non-erythroid cells. These proteins are known by such different names as fodrin, CBP I, calspectin and TW 260/240.

General readings

This product has been used in:Porter GA et al. Two populations of beta-spectrin in rat skeletal muscle. Cell Motil Cytoskeleton 37:7-19 (1997). PubMed PMID: 9142435
General / background references:Dmytrenko GM et al. Dystrophin in a membrane skeletal network: localization and comparison to other proteins. J Neurosci 13:547-58 (1993). PubMed PMID: 8426227
Winkelmann JC & Forget BG Erythroid and nonerythroid spectrins. Blood 81:3173-85 (1993). PubMed PMID: 8507859

6 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Spectrin (erythrocyte) (alpha + beta) antibody

Spectrin (erythrocyte) Mouse IgM SPN-2/B12G3 Ig Fraction Hu C, E
1 mg / €370.00
  Acris Antibodies GmbH

Spectrin beta chain (erythrocyte) / SPTB antibody

Spectrin beta chain (erythrocyte) / SPTB Mouse IgG1 DB2 Purified Hu ICC/IF, IP, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Spectrin beta chain (erythrocyte) / SPTB antibody

Spectrin beta chain (erythrocyte) / SPTB Mouse IgG1 DB2 Hu ICC/IF, IP, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

Spectrin beta chain (erythrocyte) / SPTB antibody

Spectrin beta chain (erythrocyte) / SPTB Mouse IgG1 4C3 Ascites Hu, Ms, Rt ICC/IF, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Spectrin beta chain (erythrocyte) / SPTB antibody

Immunohistochemistry-Paraffin: Spectrin beta 1 Antibody [NBP1-87596] - Immunohistochemistry-Paraffin: Spectrin beta 1 Antibody [NBP1-87596] Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Spectrin beta chain (erythrocyte) / SPTB antibody

Immunohistochemistry-Paraffin: Spectrin beta 1 Antibody [NBP1-90350] - Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

6 Item(s)

per page
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