Spectrin beta II / SPTBN1 antibody

Principal name

Spectrin beta II / SPTBN1 antibody

Alternative names for Spectrin beta II / SPTBN1 antibody

SPTB2, Spectrin beta chain brain 1, Spectrin non-erythroid beta chain 1, Beta-II spectrin, Fodrin beta chain

SwissProt ID

Q01082 (Human), Q62261 (Mouse)

Gene ID

6711 (SPTBN1), 20742 (Spnb2)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Spectrin beta II / SPTBN1 antibody

Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin β I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of β-spectrin.

6 Item(s)

per page

CRISPR

Catalog No. Species Donor Vector  

SPTBN1 - human gene knockout kit via CRISPR

SPTBN1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPTBN1 - human gene knockout kit via CRISPR

SPTBN1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sptbn1 - mouse gene knockout kit via CRISPR

Sptbn1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sptbn1 - mouse gene knockout kit via CRISPR

Sptbn1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sptbn1 - mouse gene knockout kit via CRISPR

Sptbn1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sptbn1 - mouse gene knockout kit via CRISPR

Sptbn1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

6 Item(s)

per page
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