Sphingosine kinase 2 / SPK2 antibody

Principal name

Sphingosine kinase 2 / SPK2 antibody

Alternative names for Sphingosine kinase 2 / SPK2 antibody

SK2, SPHK2

SwissProt ID

Q6AYB2 (Rat), Q9JIA7 (Mouse), Q9NRA0 (Human)

Gene ID

56848 (SPHK2), 308589 (Sphk2), 56632

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of Sphingosine kinase 2 / SPK2 antibody

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide raange of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sphingosine kinase 2 / SPK2 antibody

  Rabbit polyclonal anti-Sphingosine Kinase 2 (SPK2) antibody  
Western blot analysis of Sphingosine Kinase 2 in Jurkat cell lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Sphingosine kinase 2 / SPK2 control peptide

Sphingosine kinase 2 / SPK2 Purified
50 µg / €220.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 antibody

Western blot analysis using Sphingosine Kinase 2 antibody on 50 ng of recombinant Sphinogsine Kinase 2 enzyme. Antibody used at 1:200 dilution. Visualized using Pierce West Femto substrate system. Secondary used at 1:30k dilution. Exposure for 45 seconds. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €510.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 (Long Form) antibody

Sphingosine kinase 2 / SPK2 Rabbit Purified Hu E, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 control peptide

Sphingosine kinase 2 / SPK2 Purified
50 µg / €220.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 (Long Form) antibody

Western blot of endogneous sphingosine kinase 2 LF detection in Jurkat cell lysate (4 µg/lane) using AP05265PU-N (1 µg/ml) developed using anti-rabbit HRp (1:75K) and Pierce Super Signal west Femto. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 (N-term) antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue (hepatocarcinoma) reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue (breast carcinoma) reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Sphingosine kinase 2 / SPK2 pThr614 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using SPHK2 (Phospho-Thr614) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €230.00
  Assay Biotech

Sphingosine kinase 2 / SPK2 pThr614 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using SPHK2 (Phospho-Thr614) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €330.00
  Assay Biotech

Sphingosine kinase 2 / SPK2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SPHK2 (Ab-614) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

Sphingosine kinase 2 / SPK2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SPHK2 (Ab-614) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

SPHK2 - human gene knockout kit via CRISPR

SPHK2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPHK2 - human gene knockout kit via CRISPR

SPHK2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPHK2 - human gene knockout kit via CRISPR

SPHK2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPHK2 - human gene knockout kit via CRISPR

SPHK2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sphk2 - mouse gene knockout kit via CRISPR

Sphk2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Sphk2 - mouse gene knockout kit via CRISPR

Sphk2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sphk2 - mouse gene knockout kit via CRISPR

Sphk2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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