SPINT2 / HAI2 antibody

Principal name

SPINT2 / HAI2 antibody

Alternative names for SPINT2 / HAI2 antibody

HAI-2, Placental bikunin, Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2

SwissProt ID

O43291 (Human), Q9WU03 (Mouse)

Gene ID

10653 (SPINT2), 20733 (Spint2)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Ye (Yeast)

Available hosts

Mouse, Rat, Rabbit, Goat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SPINT2 / HAI2 antibody

Tissue damage, such as hepatic and renal injury, initiates hepatocyte growth factor activator (HGFAC)-mediated limited proteolytic activation of the inactive single-chain precursor form of HGF. Initially, HGFAC is produced as a precursor protein, which is activated by limited proteolysis and is neutralized by specific inhibitors known as HGF activator inhibitors, designated HAIs. HAIs belong to the Kunitz-type serine protease inhibitor family. HAIs target HGF activator and are involved in the regulation of proteolytic activation of HGF in injured tissues. Human HAI-1 transcript is expressed in various human tissues, such as adult placenta, kidney, pancreas, prostate and small intestine, and fetal kidney and lung. It translates into a 478 amino acid protein. The human HAI-2 gene maps to chromosome 19q13.1 and encodes a 252 amino acid protein, also designated human placental bikunin or kop (Kunitz domain containing protein over-expressed in pancreatic cancer). HAI-1 and HAI-2 are produced in membrane-associated forms, which are secreted as active, proteolytically truncated proteins.

General readings

1. Sivagnanam M, Janecke AR, Müller T, Heinz-Erian P, Taylor S, Bird LM, Case of syndromic tufting enteropathy harbors SPINT2 mutation seen in congenital sodium diarrhea.
Clinical dysmorphology 2010 Jan 19 (1): 48. PMID: 20009592

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPINT2 / HAI2 antibody

TA311498 (0.3ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPINT2 / HAI2 antibody

WB Suggested Anti-SPINT2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human heart Rabbit IgG Purified Hu, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Rat IgG2 7F52 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

Western Blot analysis of SPINT2 expression in transfected 293T cell line (H00010653-T02) by SPINT2 MaxPab polyclonal antibody.

Lane 1: SPINT2 transfected lysate(27.83 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

Western Blot analysis of SPINT2 expression in transfected 293T cell line (H00010653-T03) by SPINT2 MaxPab polyclonal antibody.

Lane 1: SPINT2 transfected lysate(27.83 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

Western Blot analysis of SPINT2 expression in transfected 293T cell line (H00010653-T04) by SPINT2 MaxPab polyclonal antibody.

Lane 1: SPINT2 transfected lysate(27.72 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

Western Blot analysis of SPINT2 expression in transfected 293T cell line (H00010653-T04) by SPINT2 MaxPab polyclonal antibody.

Lane 1: SPINT2 transfected lysate(27.72 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Mouse IgG2a 2D1 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SPINT2 / HAI2 antibody

Human Heart; WB Suggested Anti-SPINT2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human heart; SPINT2 antibody - middle region (ARP49615_P050) in Human Heart cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SPINT2 / HAI2 (C-term) antibody

SPINT2 / HAI2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SPINT2 / HAI2 antibody

Immunohistochemistry: SPINT2 Antibody [26950002] - Most of the normal tissues displayed moderate cytoplasmic positivity. Strong cytoplasmic staining was seen in exocrine pancreas and in neuronal cells while glandular cells in the intestinal tract showed strong staining of the brush border. Squamous epithelia, liver, kidney and lymphoid tissues were weakly stained or negative. Malignant tissues mainly exhibited weak to moderate cytoplasmic immunoreactivity. Lymphomas and skin cancers were negative.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit Hu E, P
50 µg / €440.00
  Novus Biologicals Inc.

SPINT2 / HAI2 antibody

SPINT2 / HAI2 Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

SPINT2 / HAI2 antibody

Immunohistochemistry-Paraffin: SPINT2 Antibody [NBP1-83299] - Immunohistochemical staining of human placenta shows distinct membranous and moderate cytoplasmic positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SPINT2 / HAI2

SPINT2 / HAI2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SPINT2 / HAI2 (transcript variant a)

SPINT2 / HAI2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

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