SPOP antibody

Principal name

SPOP antibody

Alternative names for SPOP antibody

Speckle-type POZ protein, TEF2, HIB homolog 1, Roadkill homolog 1

SwissProt ID

O43791 (Human), Q0VCW1 (Bovin), Q6ZWS8 (Mouse), Q7T330 (Danre)

Gene ID

8405 (SPOP), 20747 (Spop)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SPOP antibody

SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

General readings

Kwon J.E., et al. (2006) J. Biol. Chem. 281:12664-12672.
Furukawa M., et al. (2003) Nat. Cell Biol. 5:1001-1007.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SPOP antibody

  Rabbit Polyclonal Anti-SPOP Antibody  
WB Suggested Anti-SPOP Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysateSPOP is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SPOP - human gene knockout kit via CRISPR

SPOP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPOP - human gene knockout kit via CRISPR

SPOP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPOP - human gene knockout kit via CRISPR

SPOP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPOP - human gene knockout kit via CRISPR

SPOP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spop - mouse gene knockout kit via CRISPR

Spop - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Spop - mouse gene knockout kit via CRISPR

Spop - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spop - mouse gene knockout kit via CRISPR

Spop - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spop - mouse gene knockout kit via CRISPR

Spop - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SPOP (transcript variant 6)

  Recombinant protein of human speckle-type POZ protein (SPOP), transcript variant 6  
SPOP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SPOP (1-347, His-tag)

SPOP Human Purified > 90 % E. coli
0.25 mg / €1,000.00
  Acris Antibodies GmbH

SPOP (1-347, His-tag)

SPOP Human Purified > 90 % E. coli
50 µg / €370.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

SPOP overexpression lysate

SPOP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SPOP overexpression lysate

SPOP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SPOP overexpression lysate

SPOP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SPOP overexpression lysate

SPOP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SPOP overexpression lysate

SPOP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SPOP overexpression lysate

SPOP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SPOP (mGFP-tagged)-Human speckle-type POZ protein (SPOP), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPOP (mGFP-tagged)-Human speckle-type POZ protein (SPOP), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPOP (mGFP-tagged) - Human speckle-type POZ protein (SPOP), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPOP (mGFP-tagged) - Human speckle-type POZ protein (SPOP), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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