SPRED1 antibody

Principal name

SPRED1 antibody

Alternative names for SPRED1 antibody

Spred-1, NFLS, EVH1/Sprouty domain containing protein, Suppressor of Ras/MAPK activation

SwissProt ID

Q7Z699 (Human), Q924S8 (Mouse)

Gene ID

161742 (SPRED1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of SPRED1 antibody

The Ras-MAP kise pathway is essential for the differentiation of neurol cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF sigling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.

General readings

Nonami A., et al. (2005) Genes Cells 10:887-895.King J.A.J., et al. (2005) Biochem. J. 388:445-454.

13 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SPRED1 (Center) antibody

Western blot analysis of Spred1 in mouse brain tissue lysate with Spred1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPRED1 (Center) antibody

Western blot analysis of Spred1 in human brain tissue lysate with Spred1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPRED1 (C-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with SPRED1 antibody (C-term) (AP11428PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SPRED1 (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with SPRED1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SPRED1 antibody

Human Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SPRED1 Control Peptide

SPRED1
50 µg / €160.00
  Acris Antibodies GmbH

SPRED1 Control Peptide

SPRED1
50 µg / €160.00
  Acris Antibodies GmbH

SPRED1 antibody

SPRED1 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SPRED1 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with SPRED1 polyclonal antibody ( Cat # PAB3100 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SPRED1 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with SPRED1 polyclonal antibody ( Cat # PAB3102 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SPRED1 antibody

Immunohistochemistry-Paraffin: Spred-1 Antibody [NBP1-89836] - Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in subsets of hematopoietic cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SPRED1 (1-444, His-tag)

SPRED1 Human Purified > 80 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

SPRED1 (1-444, His-tag)

SPRED1 Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

13 Item(s)

per page
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