Sprouty homolog 1 / SPRY1 antibody

Principal name

Sprouty homolog 1 / SPRY1 antibody

Alternative names for Sprouty homolog 1 / SPRY1 antibody

Spry-1, Sprouty 1

SwissProt ID

A5D992 (Bovin), O43609 (Human), Q9PTL1 (Chick), Q9QXV9 (Mouse)

Gene ID

10252 (SPRY1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of Sprouty homolog 1 / SPRY1 antibody

Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well conserved cysteine-rich C-terminal domain with their Drosophilacounterpart. Both Sprouty 1 and 2 are anchored to membranes by palmitoylation, associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on Serine residues. Upon stimulation, a subset is recruited to the leading edge of the plasma membrane.
Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibits the activities of several growth factors. Sprouty 2 also functions as a negative regulator of embryonic lung morphogenesis and growth. The wellconserved C-terminus of Sprouty contains two domains which are necessary for Sprouty 2 colocalization with microtubules and translocation to membrane ruffles. In addition, the C-terminus is required for the inhibition of cell migration and proliferation. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.

General readings

Cabrita,M.A., (2006) J. Biol. Chem. 281 (39), 29201-22912

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sprouty homolog 1 / SPRY1 (1-111) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3H4 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Sprouty homolog 1 / SPRY1 antibody

Immunoperoxidase of monoclonal antibody to SPRY1 on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml] Mouse IgG2a 3H4 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 (C-term) antibody

Sprouty homolog 1 / SPRY1 Goat Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 1 / SPRY1 antibody

WB Suggested Anti-SPRY1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 antibody

Immunoprecipitation of SPRY1 transfected lysate using anti-SPRY1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SPRY1 MaxPab mouse polyclonal antibody (B01) (H00010252-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 antibody

Western Blot analysis of SPRY1 expression in transfected 293T cell line (H00010252-T02) by SPRY1 MaxPab polyclonal antibody.

Lane 1: SPRY1 transfected lysate(35.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Mouse IgG2a 2F1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Goat Hu, Ms E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1 antibody

Human 293T; WB Suggested Anti-SPRY1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: 293T cell lysate; SPRY1 Antibody - N-terminal region (ARP50521_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Rabbit Serum Bov, Chk, Hu, Ms P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Goat Aff - Purified Hu, Ms E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sprouty homolog 1 / SPRY1 (transcript variant 2)

Sprouty homolog 1 / SPRY1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Sprouty homolog 1 / SPRY1

Sprouty homolog 1 / SPRY1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1

Sprouty homolog 1 / SPRY1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1

Sprouty homolog 1 / SPRY1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Sprouty homolog 1 / SPRY1

Sprouty homolog 1 / SPRY1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SPRY1 293T Cell Transient Overexpression Lysate(Denatured)

SPRY1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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