Sprouty homolog 1 / SPRY1 antibody

Principal name

Sprouty homolog 1 / SPRY1 antibody

Alternative names for Sprouty homolog 1 / SPRY1 antibody

Spry-1, Sprouty 1

SwissProt ID

A5D992 (Bovin), O43609 (Human), Q9PTL1 (Chick), Q9QXV9 (Mouse)

Gene ID

10252 (SPRY1), 24063 (Spry1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of Sprouty homolog 1 / SPRY1 antibody

Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well conserved cysteine-rich C-terminal domain with their Drosophilacounterpart. Both Sprouty 1 and 2 are anchored to membranes by palmitoylation, associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on Serine residues. Upon stimulation, a subset is recruited to the leading edge of the plasma membrane.
Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibits the activities of several growth factors. Sprouty 2 also functions as a negative regulator of embryonic lung morphogenesis and growth. The wellconserved C-terminus of Sprouty contains two domains which are necessary for Sprouty 2 colocalization with microtubules and translocation to membrane ruffles. In addition, the C-terminus is required for the inhibition of cell migration and proliferation. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.

General readings

Cabrita,M.A., (2006) J. Biol. Chem. 281 (39), 29201-22912

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sprouty homolog 1 / SPRY1 (1-111) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3H4 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Sprouty homolog 1 / SPRY1 (C-term) antibody

  Goat Anti-Sprouty Antibody  
Sprouty homolog 1 / SPRY1 Goat Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 1 / SPRY1 antibody

  Rabbit Polyclonal Anti-SPRY1 Antibody  
WB Suggested Anti-SPRY1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 1 / SPRY1 antibody

Sprouty homolog 1 / SPRY1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SPRY1 - human gene knockout kit via CRISPR

SPRY1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPRY1 - human gene knockout kit via CRISPR

SPRY1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPRY1 - human gene knockout kit via CRISPR

SPRY1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPRY1 - human gene knockout kit via CRISPR

SPRY1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spry1 - mouse gene knockout kit via CRISPR

Spry1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Spry1 - mouse gene knockout kit via CRISPR

Spry1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spry1 - mouse gene knockout kit via CRISPR

Spry1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spry1 - mouse gene knockout kit via CRISPR

Spry1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sprouty homolog 1 / SPRY1 (transcript variant 2)

  Purified recombinant protein of Homo sapiens sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1), transcript variant 2  
Sprouty homolog 1 / SPRY1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SPRY1 overexpression lysate

SPRY1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SPRY1 overexpression lysate

SPRY1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SPRY1 (mGFP-tagged) - Human sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPRY1 (mGFP-tagged) - Human sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPRY1 (Myc-DDK tagged) - Human sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SPRY1 (Myc-DDK tagged) - Human sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Spry1 (GFP-tagged) - Mouse sprouty homolog 1 (Drosophila) (cDNA clone MGC:18307 IMAGE:3672353), 200 uL, >10^7 TU/mL

Lenti ORF particles, Spry1 (GFP-tagged) - Mouse sprouty homolog 1 (Drosophila) (cDNA clone MGC:18307 IMAGE:3672353), 200 uL, >10^7 TU/mL  
200 µl / €790.00
  OriGene Technologies, Inc.

Lenti ORF particles, Spry1 (GFP-tagged) - Mouse sprouty homolog 1 (Drosophila) (Spry1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Spry1 (GFP-tagged) - Mouse sprouty homolog 1 (Drosophila) (Spry1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Spry1 (Myc-DDK-tagged) - Mouse sprouty homolog 1 (Drosophila) (cDNA clone MGC:18307 IMAGE:3672353), 200 uL, >10^7 TU/mL

Lenti ORF particles, Spry1 (Myc-DDK-tagged) - Mouse sprouty homolog 1 (Drosophila) (cDNA clone MGC:18307 IMAGE:3672353), 200 uL, >10^7 TU/mL  
200 µl / €700.00
  OriGene Technologies, Inc.

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