Sprouty homolog 2 / SPRY2 antibody

Principal name

Sprouty homolog 2 / SPRY2 antibody

Alternative names for Sprouty homolog 2 / SPRY2 antibody

Spry-2, Sprouty 2

SwissProt ID

O43597 (Human), Q08E39 (Bovin), Q9PTL2 (Chick), Q9QXV8 (Mouse)

Gene ID

10253 (SPRY2), 24064 (Spry2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Chk (Chicken), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Sprouty homolog 2 / SPRY2 antibody

SPRY2 is a protein belonging to the sprouty family. It contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. SPRY2 is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. SPRY2 may play a role in alveoli branching during lung development as shown by a similar mouse protein.This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Lee,S.A., (2008) Hepatology 47 (4), 1200-1210

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sprouty homolog 2 / SPRY2 antibody

Immunoperoxidase of monoclonal antibody to SPRY2 on formalin-fixed paraffin-embedded human lymphoma. [antibody concentration 3ug/ml] Mouse IgG 1E10 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Sprouty homolog 2 / SPRY2 antibody

  Rabbit polyclonal Sprouty-2 antibody  
Immunohistochemistry of Rabbit anti-Sprouty2 antibody. Tissue: human kidney clear cell tumor. Fixation: formalin fixed, paraffin embedded. Antigen retrieval: yes. Primary antibody: Sprouty2 antibody at 1:250. Secondary antibody: alexafluor 488 secondary at 1:500 overnight at 4°C. Localization: nucleus and cytoplasm. Staining: green = sprouty2, Blue = dapi, red= vhl. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 2 / SPRY2 antibody

  Rabbit Polyclonal Anti-SPRY2 Antibody  
WB Suggested Anti-SPRY2 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 2 / SPRY2 antibody

  Rabbit Polyclonal Anti-SPRY2 Antibody  
WB Suggested Anti-SPRY2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Sprouty homolog 2 / SPRY2 antibody

Sprouty homolog 2 / SPRY2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Sprouty homolog 2 / SPRY2 antibody

Western Blot analysis of SPRY2 expression in transfected 293T cell line (H00010253-T02) by SPRY2 MaxPab polyclonal antibody.

Lane 1: SPRY2 transfected lysate(34.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Sprouty homolog 2 / SPRY2 antibody

Human HepG2; WB Suggested Anti-SPRY2 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; SPRY2 antibody - N-terminal region (ARP50523_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Sprouty homolog 2 / SPRY2 antibody

Human THP-1; WB Suggested Anti-SPRY2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: THP-1 cell lysate; SPRY2 antibody - middle region (ARP50524_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

SPRY2 - human gene knockout kit via CRISPR

SPRY2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SPRY2 - human gene knockout kit via CRISPR

SPRY2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPRY2 - human gene knockout kit via CRISPR

SPRY2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SPRY2 - human gene knockout kit via CRISPR

SPRY2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spry2 - mouse gene knockout kit via CRISPR

Spry2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Spry2 - mouse gene knockout kit via CRISPR

Spry2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spry2 - mouse gene knockout kit via CRISPR

Spry2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Spry2 - mouse gene knockout kit via CRISPR

Spry2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sprouty homolog 2 / SPRY2

  Recombinant protein of human sprouty homolog 2 (Drosophila) (SPRY2)  
Sprouty homolog 2 / SPRY2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Sprouty homolog 2 / SPRY2

Sprouty homolog 2 / SPRY2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Sprouty homolog 2 / SPRY2

Sprouty homolog 2 / SPRY2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SPRY2 overexpression lysate

SPRY2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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