SPTLC1 antibody

Principal name

SPTLC1 antibody

Alternative names for SPTLC1 antibody

Serine palmitoyltransferase 1, SPT 1, SPT1, LCB 1, LCB1, Serine-palmitoyl-CoA transferase 1, Long chain base biosynthesis protein 1

SwissProt ID

O15269 (Human), O35704 (Mouse), Q3MHG1 (Bovin)

Gene ID

10558 (SPTLC1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ye (Yeast), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP)

Background of SPTLC1 antibody

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5\'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5\'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.

General readings

1. Dawkins, J. L., Hulme, D. J., Brahmbhatt, S. B., Auer-Grumbach, M., Nicholson, G. A.Mutations in
SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary
sensory neuropathy type I.Nature Genet. 27: 309-312, 2001.
2. McCampbell, A., Truong, D., Broom, D. C., Allchorne, A., Gable, K., Cutler, R. G., Mattson, M. P.,
Woolf, C. J., Frosch, M. P., Harmon, J. M., Dunn, T. M., Brown, R. H., Jr.Mutant SPTLC1 dominantly
inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.Hum.
Molec. Genet. 14: 3507-3521, 2005.
3. Verhoeven, K., Coen, K., De Vriendt, E., Jacobs, A., Van Gerwen, V., Smouts, I., Pou-Serradell, A.,
Martin, J.-J., Timmerman, V., De Jonghe, P.SPTLC1 mutation in twin sisters with hereditary sensory
neuropathy type I.Neurology 62: 1001-1002, 2004.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SPTLC1 (C-term) antibody

Western blot analysis of SPT1 in human lung tissue lysate with SPT1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPTLC1 antibody

WB Suggested Anti-SPTLC1 Antibody Titration: 0.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ye, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SPTLC1 antibody

WB Suggested Anti-SPTLC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SPTLC1 antibody

SPTLC1 Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

SPTLC1 Control Peptide

SPTLC1 Purified C, WB
50 µg / €210.00
  Acris Antibodies GmbH

SPTLC1 antibody

Immunohistochemical staining of normal Human lung tissue with Serine Palmitoyltransferase 1 antibody (Cat.-No AP05280PU-N) at 15 μg/ml. Rabbit IgG Aff - Purified Hu C, WB
10 Blots / €480.00
  Acris Antibodies GmbH

SPTLC1 (N-term) antibody

Western blot analysis of anti-SPTLC1 Antibody (N-term)(Cat.#AP12258PU-N) in 293 cell line lysates (35ug/lane). SPTLC1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SPTLC1 (C-term) antibody

Western blot analysis of anti-SPTLC1 Antibody (C-term)(Cat.#AP12259PU-N) in 293 cell line lysates (35ug/lane). SPTLC1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SPTLC1 antibody

SPTLC1 Mouse IgG2a 3D11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SPTLC1 antibody

The SPTLC1 polyclonal antibody ( Cat # PAB2501 ) is used in Western blot to detect SPTLC1 in 293 cell lysate. Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SPTLC1 antibody

The SPTLC1 polyclonal antibody ( Cat # PAB4378 ) is used in Western blot to detect SPTLC1 in mouse liver tissue lysate . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SPTLC1 antibody

Human kidney; SPTLC1 antibody - middle region (ARP46721_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

SPTLC1 antibody

Human Brain; WB Suggested Anti-SPTLC1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human brain; SPTLC1 antibody - middle region (ARP46722_P050) in Human Brain cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

SPTLC1 antibody

SPTLC1 Rabbit IgG Aff - Purified Hu P, WB
0.1 mg / €290.00
  Boster Immunoleader

SPTLC1 antibody

Western Blot: SPTLC1 Antibody [NBP1-59643] - This Anti-SPTLC1 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 0.5ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €440.00
  Novus Biologicals Inc.

SPTLC1 antibody

Western Blot: SPTLC1 Antibody [NBP1-59644] - This Anti-SPTLC1 antibody was used in Western Blot of Fetal Brain tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Xen, Ze WB
50 µg / €440.00
  Novus Biologicals Inc.

SPTLC1 antibody

Immunohistochemistry-Paraffin: SPTLC1 Antibody [NBP1-81737] Immunohistochemical staining of human breast shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SPTLC1 (transcript variant 1)

SPTLC1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SPTLC1

SPTLC1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SPTLC1

SPTLC1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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