SPTLC1 antibody

Principal name

SPTLC1 antibody

Alternative names for SPTLC1 antibody

Serine palmitoyltransferase 1, SPT 1, SPT1, LCB 1, LCB1, Serine-palmitoyl-CoA transferase 1, Long chain base biosynthesis protein 1

SwissProt ID

O15269 (Human), O35704 (Mouse), Q3MHG1 (Bovin)

Gene ID

10558 (SPTLC1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ye (Yeast), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of SPTLC1 antibody

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5\'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5\'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.

General readings

1. Dawkins, J. L., Hulme, D. J., Brahmbhatt, S. B., Auer-Grumbach, M., Nicholson, G. A.Mutations in
SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary
sensory neuropathy type I.Nature Genet. 27: 309-312, 2001.
2. McCampbell, A., Truong, D., Broom, D. C., Allchorne, A., Gable, K., Cutler, R. G., Mattson, M. P.,
Woolf, C. J., Frosch, M. P., Harmon, J. M., Dunn, T. M., Brown, R. H., Jr.Mutant SPTLC1 dominantly
inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.Hum.
Molec. Genet. 14: 3507-3521, 2005.
3. Verhoeven, K., Coen, K., De Vriendt, E., Jacobs, A., Van Gerwen, V., Smouts, I., Pou-Serradell, A.,
Martin, J.-J., Timmerman, V., De Jonghe, P.SPTLC1 mutation in twin sisters with hereditary sensory
neuropathy type I.Neurology 62: 1001-1002, 2004.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SPTLC1 (C-term) antibody

  Rabbit Polyclonal SPT1 Antibody  
Western blot analysis of SPT1 in human lung tissue lysate with SPT1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SPTLC1 antibody

  Rabbit Polyclonal Anti-SPTLC1 Antibody  
WB Suggested Anti-SPTLC1 Antibody Titration: 0.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ye, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SPTLC1 antibody

  Rabbit Polyclonal Anti-SPTLC1 Antibody  
WB Suggested Anti-SPTLC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SPTLC1 antibody

SPTLC1 Rabbit IgG Purified Hu WB
0.1 mg / €380.00
  Acris Antibodies GmbH

SPTLC1 Control Peptide

SPTLC1 Purified C, WB
50 µg / €220.00
  Acris Antibodies GmbH

SPTLC1 antibody

Immunohistochemical staining of normal Human lung tissue with Serine Palmitoyltransferase 1 antibody (Cat.-No AP05280PU-N) at 15 μg/ml. Rabbit IgG Aff - Purified Hu C, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

SPTLC1 (N-term) antibody

Western blot analysis of anti-SPTLC1 Antibody (N-term)(Cat.#AP12258PU-N) in 293 cell line lysates (35ug/lane). SPTLC1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SPTLC1 (C-term) antibody

Western blot analysis of anti-SPTLC1 Antibody (C-term)(Cat.#AP12259PU-N) in 293 cell line lysates (35ug/lane). SPTLC1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SPTLC1 (transcript variant 1)

  Recombinant protein of human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 1  
SPTLC1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

SPTLC1 overexpression lysate

SPTLC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SPTLC1 (mGFP-tagged) - Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPTLC1 (mGFP-tagged) - Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,080.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPTLC1 (mGFP-tagged)-Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPTLC1 (mGFP-tagged)-Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPTLC1 (Myc-DDK tagged) - Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SPTLC1 (Myc-DDK tagged) - Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

Lenti ORF particles, SPTLC1 (Myc-DDK-tagged)-Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SPTLC1 (Myc-DDK-tagged)-Human serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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