SQSTM1 antibody

Principal name

SQSTM1 antibody

Alternative names for SQSTM1 antibody

Sequestosome-1, EBIAP, ORCA, OSIL, p60, p62, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa

SwissProt ID

O08623 (Rat), Q13501 (Human), Q64337 (Mouse)

Gene ID

8878 (SQSTM1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Ze (Zebrafish), African clawed frog, Sh (Sheep), Mky (Monkey), Prim (Primate)

Available hosts

Guinea Pig, Mouse, Rabbit, Sheep

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP)

Background of SQSTM1 antibody

p62/SQSTM1 (sequestosome 1) is ubiquitously-expressed cytoplasmic/adapter protein conserved in vertebrates and it can be induced by proteasomal inhibitor PSI, PGJ2/prostaglandin J2 as well as phorbol 12-myristate 13-acetate (PMA). SQSTM1 has the ability of ubiquitin binding as well as regulating NFkB1 activation by TNF-alpha, NGF (nerve growth factor) and interleukin-1. SQSTM1 acts as an adapter that mediates the interaction between TRAF6 and CYLD, and SQSTM1-TRAF6 interaction leads to K63-linked polyubiquitition of TRAF6 followed by subsequent activation of NFkB pathway. SQSTM1 plays a role in TITIN/TTN downstream sigling in muscle cells and regulate sigling cascades through ubiquitition. SQSTM1 is essential both for formation and autophagic degradation of polyubiquitin-containing bodies which are known as aggresome-like induced structures (ALIS) and SQSTM1 connects ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. Moreover, while autophagy modulates SQSTM1 protein levels, SQSTM1 suppresses autophagy via activation of mTORC1. SQSTM1 interacts with KEAP1, which is a cytoplasmic inhibitor of NRF2, a key transcription factor involved in cellular responses to oxidative stress. SQSTM1 functions as a sigling hub for various sigl transduction pathways, apoptosis, cell differentiation, apoptosis, immune response, regulation of K+ channels and Nrf2 activation, and its dysregulation is associated with Paget disease of bone and tumorigenesis.

General readings

Strausberg, R.L et al. Proc. Natl. Acad. Sci. U.S.S. 99 (26) 16899-16903 (2002)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SQSTM1 antibody

Anti-SQSTM1 mouse monoclonal antibody (TA502239) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SQSTM1(RC203214). Mouse IgG2a OTI6A7 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

SQSTM1 Mouse IgG2b UMAB12 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of human liver tissue using anti-SQSTM1mouse monoclonal antibody. (Clone UMAB13, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB13 Purified Hu F, ICC/IF, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

SQSTM1 antibody

SQSTM1 Mouse IgG2b UMAB12 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of human liver tissue using anti-SQSTM1mouse monoclonal antibody. (Clone UMAB13, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB13 Purified Hu F, ICC/IF, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

SQSTM1 (C-term) antibody

Western blot analysis of SQSTM1 Antibody (C331) Pab (Cat.#TA300177) pre-incubated without(lane 1) and with(lane 2) blocking peptide in MCF-7 cell line lysate. SQSTM1 Antibody (C331) (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SQSTM1 antibody

Western Blot: p62/SQSTM1 Antibody (5H7E2) [TA336949] - Western blot analysis using p62/SQSTM1 mAb against human SQSTM1 recombinant protein. (Expected MW is 39.1 kDa) Mouse IgG1 5H7E2 Purified Hu, Prim C, E, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502127) Mouse IgG2b OTI1E9 Purified Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502128) Mouse IgG1 OTI4A12 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502129) Mouse IgG2b OTI5D5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502130) Mouse IgG1 OTI4E2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502131) Mouse IgG1 OTI5A2 Purified Hu, Mky F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502132) Mouse IgG1 OTI4G9 Purified Hu, Mky F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Anti-SQSTM1 mouse monoclonal antibody (TA502133) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SQSTM1(RC203214). Mouse IgG2a OTI4C8 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Anti-SQSTM1 mouse monoclonal antibody (TA502174) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SQSTM1(RC203214). Mouse IgG1 OTI7F6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502238) Mouse IgG2a OTI5A1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SQSTM1 antibody

Human Pancreas; Pancreas; SQSTM1 antibody - middle region (ARP54262_P050) in Human Pancreas cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

SQSTM1 (C-term) antibody

Western blot analysis of SQSTM1 in Human spleen tissue lysate with SQSTM1 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SQSTM1 antibody

Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with polyclonal anti-p62 antibody (Clone Poly6477). Proteins were visualized using donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Poly6477 Purified Hu WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

SQSTM1 antibody

Western Blot: p62/SQSTM1 Antibody [TA336759] - Analysis of SQSTM1 in HeLa whole cell extracts Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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