SR-alpha / SRPR antibody

Principal name

SR-alpha / SRPR antibody

Alternative names for SR-alpha / SRPR antibody

Signal recognition particle receptor subunit alpha, SR alpha, Docking protein alpha, DP-alpha

SwissProt ID

O43032 (Schpo), P06625 (Canfa), P08240 (Human), P32916 (Yeast), Q3MHE8 (Bovin), Q9DBG7 (Mouse), Q9U5L1 (Drome)

Gene ID

6734 (SRPR)

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Sheep, Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of SR-alpha / SRPR antibody

The receptor for Signal Recognition Particle (SRP) is the site on the endoplasmic reticulum that ribosomes translating secreted and integral membrane proteins are initially targeted to. Once the ribosome-SRP complex arrives at the SRP receptor the protein being translated is transferred to the translocation complex (Sec61) in the ER membrane. The SRP receptor is composed of two subunits SRalpha and SRbeta. The SRalpha subunit is a translocation GTPase peripherally bound to the endoplasmic reticulum by its interaction with SRbeta. SRalpha also binds to the GTPase of SRP (SRP54) and these two proteins appear to function as each others GTPase activating proteins (GAPs). Hydrolysis of GTP by SRalpha and SRP54 is thought to be involved in transfer of the nascent protein to the Sec61 complex in the ER. SRalpha has an apparent molecular weight of 72 kDa. SRbeta is a Type I transmembrane protein that spans the membrane once and contains Ras type GTPase domain. The function of the GTPase in SRbeta is unknown. The membrane spanning domain is at the amino-terminus of SRbeta. The GTPase domain encompasses three quarters of the protein and is carboxyl- of the transmembrane region. SRalpha binds to the GTPase domain of SRbeta. Heterodimerization of SRalpha and SRbeta masks the carboxyl-terminal epitope of SRbeta.

General readings

Rush,J., (2005) Nat. Biotechnol. 23 (1), 94-101

14 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SR-alpha / SRPR antibody

WB Suggested Anti-SRPR Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SR-alpha / SRPR antibody

WB Suggested Anti-SRPR Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SR-alpha / SRPR antibody

SR-alpha / SRPR Sheep IgG Purified Can, Chk WB
0.25 mg / €360.00
  Acris Antibodies GmbH

SR-alpha / SRPR antibody

Western Blot analysis of SRPR expression in transfected 293T cell line (H00006734-T01) by SRPR MaxPab polyclonal antibody.

Lane 1: SRPR transfected lysate(70.18 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SR-alpha / SRPR antibody

Western Blot analysis of SRPR expression in transfected 293T cell line (H00006734-T01) by SRPR MaxPab polyclonal antibody.

Lane 1: SRPR transfected lysate(70.18 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SR-alpha / SRPR antibody

SR-alpha / SRPR Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SR-alpha / SRPR antibody

Western blot analysis using SR alpha polyclonal antibody ( Cat # PAB10405 ) on canine microsomal protein. Sheep IgG Hu IP, WB
0.25 mg / €400.00
  Abnova Taiwan Corp.

SR-alpha / SRPR antibody

Human HeLa; WB Suggested Anti-SRPR Antibody Titration: 0.2-1 ug/ml. Positive Control: Hela cell lysate; SRPR antibody - N-terminal region (ARP40459_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SR-alpha / SRPR antibody

Human HepG2; WB Suggested Anti-SRPR Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; SRPR antibody - middle region (ARP40460_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SR-alpha / SRPR antibody

Western Blot: SRPR alpha Antibody [NBP1-32421] - (30 µg of whole cell lysate) A:293T B:A431 7.5% SDS PAGE diluted at 1:1000 Rabbit IgG Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SR-alpha / SRPR (transcript variant 2)

SR-alpha / SRPR Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SR-alpha / SRPR

SR-alpha / SRPR Human
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SRPR 293T Cell Transient Overexpression Lysate(Denatured)

SRPR 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

SRPR overexpression lysate

SRPR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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