SR-beta antibody

Principal name

SR-beta antibody

Alternative names for SR-beta antibody

Signal recognition particle receptor subunit beta, SR beta, SRPRB, PSEC0230, APMCF1

SwissProt ID

P47758 (Mouse), Q4FZX7 (Rat), Q9Y5M8 (Human)

Gene ID

58477 (SRPRB), 20818 (Srprb), 300965

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Dros (Drosophila), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), Rb (Rabbit), Ye (Yeast), GP (Guinea Pig)

Available hosts

Sheep, Mouse, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E)

Background of SR-beta antibody

The receptor for Signal Recognition Particle (SRP) is the site on the endoplasmic reticulum that ribosomes translating secreted and integral membrane proteins are initially targeted to. Once the ribosome-SRP complex arrives at the SRP receptor the protein being translated is transferred to the translocation complex (Sec61) in the ER membrane. The SRP receptor is composed of two subunits SRalpha and SRbeta. The SRalpha subunit is a translocation GTPase peripherally bound to the endoplasmic reticulum by its interaction with SRbeta. SRalpha also binds to the GTPase of SRP (SRP54) and these two proteins appear to function as each others GTPase activating proteins (GAPs). Hydrolysis of GTP by SRalpha and SRP54 is thought to be involved in transfer of the nascent protein to the Sec61 complex in the ER. SRalpha has an apparent molecular weight of 72 kDa. SRbeta is a Type I transmembrane protein that spans the membrane once and contains Ras type GTPase domain. The function of the GTPase in SRbeta is unknown. The membrane spanning domain is at the amino-terminus of SRbeta. The GTPase domain encompasses three quarters of the protein and is carboxyl- of the transmembrane region. SRalpha binds to the GTPase domain of SRbeta. Heterodimerization of SRalpha and SRbeta masks the carboxyl-terminal epitope of SRbeta.

General readings

Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SR-beta antibody

  Rabbit Polyclonal Anti-SRPRB Antibody  
WB Suggested Anti-SRPRB Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate. SRPRB is supported by BioGPS gene expression data to be expressed in HeLa Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt, Ye, Ze ICC/IF, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SR-beta antibody

  SRPRB mouse monoclonal antibody, clone OTI2B9 (formerly 2B9)  
Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504698) Mouse IgG2b OTI2B9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

  SRPRB mouse monoclonal antibody, clone OTI1D9 (formerly 1D9)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504712) Mouse IgG1 OTI1D9 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

  SRPRB mouse monoclonal antibody, clone OTI3E6 (formerly 3E6)  
Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504715) Mouse IgG1 OTI3E6 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

  SRPRB mouse monoclonal antibody, clone OTI2D4 (formerly 2D4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504724) Mouse IgG1 OTI2D4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

  SRPRB mouse monoclonal antibody, clone OTI2D7 (formerly 2D7)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504725) Mouse IgG1 OTI2D7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

  Rabbit Polyclonal Anti-SRPRB Antibody  
WB Suggested Anti-SRPRB Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SR-beta antibody

  Rabbit Polyclonal Anti-SRPRB Antibody  
Gel: 8%SDS-PAGE,Lysate: 40 ug,Lane 1-7: Jurkat cells, Hela cells, 293T cells, 231 cells, HepG2 cells, Human normal liver tissue, Human bladder carcinoma tissue,Primary antibody: (SRPRB Antibody) at dilution 1/500 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SR-beta antibody

  SRPRB mouse monoclonal antibody, clone OTI5G5 (formerly 5G5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SRPRB (RC209486, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SRPRB. Mouse IgG1 OTI5G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Western blot analysis using SRbeta antibody (AP05313PU-N) on 3 (1), 6 (2) and 12 (3) ng of canine microsomal protein Sheep IgG Purified Can, Chk C, WB
0.25 mg / €370.00
  Acris Antibodies GmbH

SR-beta (C-term) antibody

Western blot analysis of SRPRB Antibody (C-term) Cat.-No AP54047PU-N in MCF-7 cell line lysates (35ug/lane).This demonstrates the SRPRB antibody detected the SRPRB protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SRPRB - human gene knockout kit via CRISPR

SRPRB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SRPRB - human gene knockout kit via CRISPR

SRPRB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SRPRB - human gene knockout kit via CRISPR

SRPRB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SRPRB - human gene knockout kit via CRISPR

SRPRB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SR-beta

  Recombinant protein of human signal recognition particle receptor, B subunit (SRPRB)  
SR-beta Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SRPRB (mGFP-tagged) - Human signal recognition particle receptor, B subunit (SRPRB), 200 uL, >10^7 TU/mL

Lenti ORF particles, SRPRB (mGFP-tagged) - Human signal recognition particle receptor, B subunit (SRPRB), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, SRPRB (Myc-DDK tagged) - Human signal recognition particle receptor, B subunit (SRPRB) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SRPRB (Myc-DDK tagged) - Human signal recognition particle receptor, B subunit (SRPRB) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Srprb (GFP-tagged) - Mouse signal recognition particle receptor, B subunit (Srprb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Srprb (GFP-tagged) - Mouse signal recognition particle receptor, B subunit (Srprb), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Srprb (Myc-DDK-tagged) - Mouse signal recognition particle receptor, B subunit (Srprb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Srprb (Myc-DDK-tagged) - Mouse signal recognition particle receptor, B subunit (Srprb), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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