SR-beta antibody

Principal name

SR-beta antibody

Alternative names for SR-beta antibody

Signal recognition particle receptor subunit beta, SR beta, SRPRB, PSEC0230, APMCF1

SwissProt ID

P47758 (Mouse), Q4FZX7 (Rat), Q9Y5M8 (Human)

Gene ID

58477 (SRPRB)

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Dros (Drosophila), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), Rb (Rabbit), Ye (Yeast), GP (Guinea Pig)

Available hosts

Sheep, Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F)

Background of SR-beta antibody

The receptor for Signal Recognition Particle (SRP) is the site on the endoplasmic reticulum that ribosomes translating secreted and integral membrane proteins are initially targeted to. Once the ribosome-SRP complex arrives at the SRP receptor the protein being translated is transferred to the translocation complex (Sec61) in the ER membrane. The SRP receptor is composed of two subunits SRalpha and SRbeta. The SRalpha subunit is a translocation GTPase peripherally bound to the endoplasmic reticulum by its interaction with SRbeta. SRalpha also binds to the GTPase of SRP (SRP54) and these two proteins appear to function as each others GTPase activating proteins (GAPs). Hydrolysis of GTP by SRalpha and SRP54 is thought to be involved in transfer of the nascent protein to the Sec61 complex in the ER. SRalpha has an apparent molecular weight of 72 kDa. SRbeta is a Type I transmembrane protein that spans the membrane once and contains Ras type GTPase domain. The function of the GTPase in SRbeta is unknown. The membrane spanning domain is at the amino-terminus of SRbeta. The GTPase domain encompasses three quarters of the protein and is carboxyl- of the transmembrane region. SRalpha binds to the GTPase domain of SRbeta. Heterodimerization of SRalpha and SRbeta masks the carboxyl-terminal epitope of SRbeta.

General readings

Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SR-beta antibody

WB Suggested Anti-SRPRB Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate. SRPRB is supported by BioGPS gene expression data to be expressed in HeLa Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt, Ye, Ze ICC/IF, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SR-beta antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504698) Mouse IgG2b OTI2B9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504712) Mouse IgG1 OTI1D9 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504715) Mouse IgG1 OTI3E6 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504724) Mouse IgG1 OTI2D4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SRPRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA504725) Mouse IgG1 OTI2D7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Human Bronchial Epithelial Tissue; Rabbit Anti-SRPRB Antibody . Catalog Number: ARP49643_P050 . Formalin Fixed Paraffin Embedded Tissue: Human Bronchial Epithelial Tissue . Observed Staining: Cytoplasmic . Primary Antibody Concentration: 1:100 . Other Working Concentrations: 1/600 . Secondary Antibody: Donkey anti-Rabbit-Cy3 . Secondary Antibody Concentration: 1:200 . Magnification: 20X . Exposure Time: 0.5 - 2.0 sec .; Rabbit Anti-SRPRB Antibody (ARP49643_P050) ) in Human Bronchial Epithelial Tissue using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Can, Chk, Dros, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

SR-beta antibody

WB Suggested Anti-SRPRB Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SR-beta antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SRPRB (RC209486, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SRPRB. Mouse IgG1 OTI5G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SR-beta antibody

Western blot analysis using SRbeta antibody (AP05313PU-N) on 3 (1), 6 (2) and 12 (3) ng of canine microsomal protein Sheep IgG Purified Can, Chk C, WB
0.25 mg / €360.00
  Acris Antibodies GmbH

SR-beta (C-term) antibody

Western blot analysis of SRPRB Antibody (C-term) Cat.-No AP54047PU-N in MCF-7 cell line lysates (35ug/lane).This demonstrates the SRPRB antibody detected the SRPRB protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SR-beta antibody

SRPRB MaxPab polyclonal antibody. Western Blot analysis of SRPRB expression in human kidney. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SR-beta antibody

Western blot analysis using SR beta polyclonal antibody ( Cat # PAB10406 ) on 3 (1),6 (2) and 12 (3) ng of canine microsomal protein. Sheep IgG Hu IP, WB
0.25 mg / €400.00
  Abnova Taiwan Corp.

SR-beta antibody

Human HepG2; WB Suggested Anti-SRPRB Antibody Titration: 5.0ug/ml. Positive Control: HepG2 cell lysate; SRPRB antibody - C-terminal region (ARP49644_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

SR-beta antibody

SR-beta Rabbit IgG Hu WB
0.1 ml / €340.00
  Novus Biologicals Inc.

SR-beta antibody

Western Blot: SRPRB Antibody [NBP1-59710] - This Anti-SRPRB antibody was used in Western Blot of Hela tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

SR-beta antibody

Immunohistochemistry-Paraffin: SRPRB Antibody [NBP1-89035] - Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SR-beta

SR-beta Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SR-beta

SR-beta Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SR-beta

SR-beta Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Items 1 to 20 of 21 total

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