SSH1 antibody

Principal name

SSH1 antibody

Alternative names for SSH1 antibody

SSH1L, SSH-1L, SSH-like protein 1, Slingshot homolog 1, KIAA1298, Protein phosphatase Slingshot homolog 1

SwissProt ID

Q8WYL5 (Human)

Gene ID

54434 (SSH1)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of SSH1 antibody

Slingshot 1 is a member of slingshot (SSH) family of protein phosphatases; it is located at human chromosome 12q24.11. Slingshot is one of the primary dedicated cofilin phosphatases. It plays an important role in cell migration by dephosphorylating cofilin at Ser3 and activating it in a variety of cell types such as keratinocytes and aortic smooth muscle cells (1). Slingshot (SSH) activity can be modulated by F-actin binding, calcium acting via calcinerium, and by its association in inhibitory complexes with 14-3-3 regulatory proteins (2). 14-3-3zeta/tau heterodimers are key regulators of slingshot 1 isoform 1 (SSH1) activity in keratinocytes (3). SSH1 is involved in H2O2 induced cofilin dephosphorylation and activation. Such activation of SSH1-cofilin pathway stimulates the SSH1 dependent formation of cofilin-actin rods in HeLa cells (4). By dephosphorylating and activating cofilin, SSH1 plays a critical role in insulin-induced membrane protrusion and cytokinesis.
SSH1 has the SSH family-specific, N-terminal, noncatalytic (SSH-N) domain. This domain has been shown to play critical roles in P-cofilin recognition, F-actin-mediated activation, and subcellular localization of SSH1 (5). Recently it was shown that expression of phosphatase-dead versions of SSH proteins resulted in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in human keratinocytes (6). SSH1 mutations were seen in patients with disseminated superficial actinic porokeratosis. SSH1 is expressed in a various cell types including keratinocytes, HeLa cells and smooth muscle cells.
It is approximately a 126kDa protein (1049 amino acids).

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CRISPR

Catalog No. Species Donor Vector  

SSH1 - human gene knockout kit via CRISPR

SSH1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SSH1 - human gene knockout kit via CRISPR

SSH1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SSH1 - human gene knockout kit via CRISPR

SSH1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SSH1 - human gene knockout kit via CRISPR

SSH1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SSH1 overexpression lysate

SSH1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SSH1 (mGFP-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SSH1 (mGFP-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, SSH1 (mGFP-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SSH1 (mGFP-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,560.00
  OriGene Technologies, Inc.

Lenti ORF particles, SSH1 (mGFP-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SSH1 (mGFP-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,580.00
  OriGene Technologies, Inc.

Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,400.00
  OriGene Technologies, Inc.

Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SSH1 (Myc-DDK-tagged)-Human slingshot homolog 1 (Drosophila) (SSH1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,420.00
  OriGene Technologies, Inc.

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