SSH1 antibody

Principal name

SSH1 antibody

Alternative names for SSH1 antibody

SSH1L, SSH-1L, SSH-like protein 1, Slingshot homolog 1, KIAA1298, Protein phosphatase Slingshot homolog 1

SwissProt ID

Q8WYL5 (Human)

Gene ID

54434 (SSH1)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of SSH1 antibody

Slingshot 1 is a member of slingshot (SSH) family of protein phosphatases; it is located at human chromosome 12q24.11. Slingshot is one of the primary dedicated cofilin phosphatases. It plays an important role in cell migration by dephosphorylating cofilin at Ser3 and activating it in a variety of cell types such as keratinocytes and aortic smooth muscle cells (1). Slingshot (SSH) activity can be modulated by F-actin binding, calcium acting via calcinerium, and by its association in inhibitory complexes with 14-3-3 regulatory proteins (2). 14-3-3zeta/tau heterodimers are key regulators of slingshot 1 isoform 1 (SSH1) activity in keratinocytes (3). SSH1 is involved in H2O2 induced cofilin dephosphorylation and activation. Such activation of SSH1-cofilin pathway stimulates the SSH1 dependent formation of cofilin-actin rods in HeLa cells (4). By dephosphorylating and activating cofilin, SSH1 plays a critical role in insulin-induced membrane protrusion and cytokinesis.
SSH1 has the SSH family-specific, N-terminal, noncatalytic (SSH-N) domain. This domain has been shown to play critical roles in P-cofilin recognition, F-actin-mediated activation, and subcellular localization of SSH1 (5). Recently it was shown that expression of phosphatase-dead versions of SSH proteins resulted in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in human keratinocytes (6). SSH1 mutations were seen in patients with disseminated superficial actinic porokeratosis. SSH1 is expressed in a various cell types including keratinocytes, HeLa cells and smooth muscle cells.
It is approximately a 126kDa protein (1049 amino acids).

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SSH1 control peptide

SSH1
0.1 mg / €250.00
  Acris Antibodies GmbH

SSH1 (Isoform 1) antibody

SSH1 Rabbit Aff - Purified E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SSH1 antibody

Western Blot analysis of SSH1 expression in transfected 293T cell line (H00054434-T01) by SSH1 MaxPab polyclonal antibody.

Lane1:SSH1 transfected lysate(115.39 KDa).
Lane2:Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SSH1 antibody

SSH1 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

SSH1 antibody

Western Blot analysis of SSH1 expression in transfected 293T cell line (H00054434-T02) by SSH1 MaxPab polyclonal antibody.

Lane 1: SSH1 transfected lysate(115.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SSH1 antibody

SSH1 Mouse IgG2a 1D2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SSH1 antibody

SSH1 Mouse IgG2a 2F9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SSH1 antibody

Western Blot and Immunoprecipitation: SSH1 Antibody [NB100-60671] - Detection of Human SSH1 on HeLa whole cell lysate using NB100-60671. SSH1 was also immunoprecipitated by rabbit anti-SSH1 antibodies NB100-60672 and NB100-60673. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

SSH1 antibody

Western Blot and Immunoprecipitation: SSH1 Antibody [NB100-60672] - Detection of Human SSH1 on HeLa whole cell lysate using NB100-60672. SSH1 was also immunoprecipitated by rabbit anti-SSH1 antibodies NB100-60671 and NB100-60673. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

SSH1 antibody

Western Blot and Immunoprecipitation: SSH1 Antibody [NB100-60673] - Detection of Human SSH1 on HeLa whole cell lysate using NB100-60673. SSH1 was also immunoprecipitated by rabbit anti-SSH1 antibodies NB100-60671 and NB100-60672. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SSH1

SSH1 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

SSH1

SSH1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SSH1

SSH1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

SSH1

SSH1 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

SSH1

SSH1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SSH1

SSH1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SSH1 293T Cell Transient Overexpression Lysate(Denatured)

SSH1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

SSH1 overexpression lysate

SSH1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

18 Item(s)

per page
  • LinkedIn