SSRP1 / FACT80 antibody

Principal name

SSRP1 / FACT80 antibody

Alternative names for SSRP1 / FACT80 antibody

FACT complex subunit SSRP1, FACTp80, T160, Facilitates chromatin transcription complex subunit SSRP1, FACT 80 kDa subunit, Chromatin-specific transcription elongation factor 80 kDa subunit, Structure-specific recognition protein 1, Recombination signal sequence recognition protein 1

SwissProt ID

Q04678 (Chick), Q04931 (Rat), Q08943 (Mouse), Q08945 (Human), Q9W602 (Xenla)

Gene ID

6749 (SSRP1), 20833 (Ssrp1), 81785

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), African clawed frog, Dros (Drosophila), Ze (Zebrafish), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), ChIP assay (ChIP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of SSRP1 / FACT80 antibody

SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. It also functions as a co-activator of the transcriptional activator p63. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Li,Y., (2007) J. Biol. Chem. 282 (10), 6936-6945

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SSRP1 / FACT80 antibody

  Rabbit polyclonal antibody to SSRP1 (structure specific recognition protein 1)  
Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. TA308461 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 (308-524) antibody

  Mouse Monoclonal anti-SSRP1 Antibody  
Hela cell lysate was resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal anti-SSRP1 antibody. Proteins were detected using a goat anti-mouse Ig secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG2b 10D1 Purified Hu ChIP, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

  Mouse Monoclonal anti-SSRP1 Antibody  
293E cell extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified anti-SSRP1 Antibody (clone 3E4). Proteins were visualized using a goat anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG1 3E4 Purified Hu ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

  Rabbit Polyclonal anti-SSRP1 antibody  
WB Suggested Anti-SSRP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: OVCAR-3 cell lysateSSRP1 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

  Rabbit Polyclonal Anti-SSRP1 Antibody  
WB Suggested Anti-SSRP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Spleen Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

  Rabbit Polyclonal Anti-SSRP1 Antibody  
SSRP1 / FACT80 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

  Rabbit Polyclonal SSRP1 Antibody  
WB was performed on nuclear extracts from HeLa cells (20 ug) using the antibody against SSRP1 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. A molecular weight marker (in kDa) is shown on the right. The location of the protein of interest is indicated by an arrow. Rabbit IgG Purified Hu
0.1 ml / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

  Rabbit Polyclonal SSRP1 Antibody  
WB was performed on nuclear extracts from HeLa cells (20 ug) using the antibody against hSSRP1 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. A molecular weight marker (in kDa) is shown on the left. The location of the protein of interest is indicated by an arrow. Rabbit IgG Purified Hu
50 µg / €325.00
  OriGene Technologies, Inc.

SSRP1 / FACT80 antibody

SSRP1 / FACT80 Rabbit IgG Purified Hu, Ms IP, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

SSRP1 / FACT80 antibody

SSRP1 / FACT80 Rabbit IgG Purified Hu, Ms IP, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

SSRP1 / FACT80 (C-term) antibody

Western blot analysis of SSRP1 / FACT80 Antibody (C-term) Cat.-No AP54054PU-N in CEM cell line lysates (35ug/lane). This demonstrates the SSRP1 antibody detected the SSRP1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SSRP1 - human gene knockout kit via CRISPR

SSRP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SSRP1 - human gene knockout kit via CRISPR

SSRP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SSRP1 - human gene knockout kit via CRISPR

SSRP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SSRP1 - human gene knockout kit via CRISPR

SSRP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ssrp1 - mouse gene knockout kit via CRISPR

Ssrp1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SSRP1 / FACT80

  Recombinant protein of human structure specific recognition protein 1 (SSRP1)  
SSRP1 / FACT80 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SSRP1 (mGFP-tagged) - Human structure specific recognition protein 1 (SSRP1), 200 uL, >10^7 TU/mL

Lenti ORF particles, SSRP1 (mGFP-tagged) - Human structure specific recognition protein 1 (SSRP1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SSRP1 (Myc-DDK tagged) - Human structure specific recognition protein 1 (SSRP1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SSRP1 (Myc-DDK tagged) - Human structure specific recognition protein 1 (SSRP1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ssrp1 (GFP-tagged) - Mouse structure specific recognition protein 1 (cDNA clone MGC:30412 IMAGE:5005209), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ssrp1 (GFP-tagged) - Mouse structure specific recognition protein 1 (cDNA clone MGC:30412 IMAGE:5005209), 200 uL, >10^7 TU/mL  
200 µl / €1,390.00
  OriGene Technologies, Inc.

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