ST13 / HIP antibody

Principal name

ST13 / HIP antibody

Alternative names for ST13 / HIP antibody

Hsc70-interacting protein, FAM10A1, NY-REN-33, SNC6, Suppression of tumorigenicity 13 protein, Putative tumor suppressor ST13, Progesterone receptor-associated p48 protein

SwissProt ID

C4NYP8 (Drome), P50502 (Human), P50503 (Rat), Q5ZLF0 (Chick), Q99L47 (Mouse)

Gene ID

6767 (ST13), 5167670 (acpS)

Available reactivities

Chk (Chicken), Hu (Human), Rb (Rabbit), Bov (Bovine), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of ST13 / HIP antibody

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP90, HSP70), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and three other proteins termed p23, p60 and heat shock cognate protein 70 kDa (HSC70)-interacting protein (Hip), also known as p48. Hip, along with HSP70 and p60, combine with steroid receptors as transient intermediate complex members.
In vitro studies have suggested that Hip transiently interacts with progesterone receptor in a cell free system prior to hormone binding competency and dissociates from the receptor complex with the binding of an HSP90:Immunophilin:p23 subcomplex which then results in a hormone-binding-competent receptor complex. While neither its exact function nor mechanism of action have been identified, Hip appears to be an important factor in steroid receptor function. Hip also appears to regulate the function of HSC70 in an ATP hydrolysis and HSP40 dependent fashion.

General readings

This product has been used in:Prapapanich V et al. Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly. Mol Cell Biol 18:944-52 (1998). PubMed PMID: 9447991
General / background references:Prapapanich V et al. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. Mol Endocrinol 10:420-31 (1996). PubMed PMID: 8721986
Hohfeld J et al. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Cell 83:589-98 (1995). PubMed PMID: 7585962

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ST13 / HIP antibody

Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B) using ST13 mouse mAb with DAB staining. Mouse IgG1 3B10 Ascites Hu, Mky E, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

ST13 / HIP antibody

Paraffin embedded sections of human gastric cancer tissue were incubated with anti-human HIP/ST13 (1:25) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG1 AT1F1 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

ST13 / HIP antibody

Paraffin embedded sections of human gastric cancer tissue were incubated with anti-human HIP/ST13 (1:25) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG1 AT1F1 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

ST13 / HIP antibody

AP15795PU ST13 antibody staining of Human Colon Carcinoma. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

ST13 / HIP antibody

AP15795PU ST13 antibody staining of Human Colon Carcinoma. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

ST13 / HIP antibody

AP15795PU ST13 antibody staining of Human Colon Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

ST13 / HIP antibody

Host: Rabbit; Target Name: St13; Sample Tissue: Mouse Heart lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

ST13 / HIP antibody

ST13 / HIP Mouse IgG2a AT5C6 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

ST13 / HIP antibody

ST13 / HIP Mouse IgG2a AT5C6 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

ST13 / HIP (60-75) antibody

Figure 1. Staining ST13 (HIP) in Adrenal by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

ST13 / HIP (N-term) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with ST13 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ST13 / HIP antibody

ST13 MaxPab polyclonal antibody. Western Blot analysis of ST13 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

ST13 / HIP antibody

ST13 / HIP Mouse IgG2a 2B2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ST13 / HIP antibody

Paraffin embedded sections of human gastric cancer tissue were incubated with ST13 monoclonal antibody, clone AT1F1 ( Cat # MAB3212 ; 1 : 25 ) for 2 hours at room temperature.
Antigen retrieval was performed in 100 mM sodium citrate buffer and detected using Diaminobenzidine ( DAB ). Mouse IgG1 AT1F1 Hu E, P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

ST13 / HIP antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with ST13 polyclonal antibody ( Cat # PAB4827 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

ST13 / HIP antibody

ST13 / HIP Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

ST13 / HIP antibody

ST13 / HIP Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

ST13 / HIP antibody

ST13 / HIP Mouse IgG 2G6 Purified Chk, Hu, Rb ICC/IF, IP, WB
0.125 mg / €400.00
  Novus Biologicals Inc.

ST13 / HIP antibody

Western Blot: Hsp70 interacting protein HIP Antibody [NB120-13490] - analysis of rat testis tissue extract, probed with Hsp70 interacting protein HIP [NB120-13490] polyclonal antibody. Rabbit IgG Serum Bov, Hu, Ms, Rt P, WB
0.2 mg / €510.00
  Novus Biologicals Inc.

ST13 / HIP antibody

ST13 / HIP Mouse IgG1 AT1F1 Purified Hu E, P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

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