STAT2 antibody

Principal name

STAT2 antibody

Alternative names for STAT2 antibody

p113, Signal transducer and activator of transcription 2

SwissProt ID

O02799 (Pig), P52630 (Human), Q5XI26 (Rat), Q9WVL2 (Mouse)

Gene ID

6773 (STAT2), 288774 (Stat2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of STAT2 antibody

STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STAT2 antibody

Immunohistochemistry (IHC) analyzes of STAT2 antibody (Cat.-No.: AP06326PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

STAT2 pTyr690 antibody

Western blot using affinity purified anti-Stat2pY690 antibody shows detection of Stat2pY690 protein (arrowhead) in Jurkat cells without (left lane) and with (right lane) 1000U/mL of IFN-alpha for 15 min at 37°C. Primary antibody was used at 1:1,000. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STAT2 antibody

HeLa whole cell lysate was loaded at 1 µg. The blot was blocked with 1% BSA in TBST for 30 min at RT, then washed and incubated with anti-Stat2 antibody in 3% BSA/TBST at 1:1,000 overnight at 4C. After washing, blot was incubated with HRP Rb a-Ms IgG (p/n 610-4302) antibody in blocking buffer (p/n MB-070) for 30 minutes at RT. Data was collected using Bio-Rad VersaDoc® 4000 MP. Mouse 19G8.H2.H6 Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STAT2 antibody

Predicted band size: 98 kDa . Positive control: Hela cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: Hela cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STAT2 antibody

Western blot analysis of STAT2 expression in IFN treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STAT2 antibody

Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-STAT2 polyclonal antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Poly6245 Purified Hu IP, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

STAT2 pTyr689 antibody

STAT2 Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €460.00
  Acris Antibodies GmbH

STAT2 antibody

Tonsil: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

STAT2 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2 Antibody AP08100PU. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

STAT2 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2 Antibody AP08100PU. Rabbit Aff - Purified Hu P, WB
50 µl / €230.00
  Acris Antibodies GmbH

STAT2 pTyr690 antibody

Western blot using affinity purified anti-Stat2pY690 antibody shows detection of Stat2pY690 protein (arrowhead) in Jurkat cells without (left lane) and with (right lane) 1000U/mL of IFN-alpha for 15 min at 37°C. Primary antibody was used at 1:1,000. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
25 µl / €190.00
  Acris Antibodies GmbH

STAT2 (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

STAT2 antibody

Immunofluorescence of monoclonal antibody to STAT2 on A-431 cell. [antibody concentration 10 ug/ml] Mouse IgG1 5G7 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

STAT2 antibody

STAT2 monoclonal antibody (M02), clone 2E9 Western Blot analysis of STAT2 expression in A-431 ( Cat # L015V1 ). Mouse IgG1 2E9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

STAT2 antibody

Western blot analysis of STAT2 on 10 ug/lane Jurkat cell lysate. Using STAT2 polyclonal antibody ( Cat # PAB0168 ) . Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

STAT2 antibody

Western blot analysis of STAT2 polyclonal antibody ( Cat # PAB0831 ) in expression in A-431 ( A ) and HeLa ( B ) whole cell lysates. Rabbit Hu WB
0.2 mg / €390.00
  Abnova Taiwan Corp.

STAT2 antibody

Immunoblot analysis of cell lysates. Lane 1 : HeLa cell lysate. Lane 2 : K-562 cell lysate. Lane 3 : A-431 cell lysate. N.S: Non specific band. Rabbit Hu WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

STAT2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with STAT2 polyclonal antibody ( Cat # PAB3578 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

STAT2 pTyr689 antibody

STAT2 Rabbit Hu, Ms WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

STAT2 antibody

Western blot analysis of Stat2 expression in lysate from Jurkat cells ( Lane 1, 2 ) and NIH/3T3 cells ( Lane 3 ) . Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

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