STAT6 antibody

Principal name

STAT6 antibody

Alternative names for STAT6 antibody

IL-4 Stat, Signal transducer and activator of transcription 6

SwissProt ID

P42226 (Human), P52633 (Mouse), Q1KQ07 (Rat)

Gene ID

6778 (STAT6), 362896

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Por (Porcine), Mky (Monkey), Bov (Bovine), Rb (Rabbit), Sh (Sheep), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), EPair for Elisa (EPair), ChIP assay (ChIP)

Background of STAT6 antibody

Signal Transducers and Activators of Transcription (STATs) are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors (1). Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases, and STATs are activated by tyrosine phosphorylation (2). Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including severe combined immunodeficiency and leukemia (4). STATs have been implicated in programming gene expression in biological events such as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation in many organisms (3). STAT1 knockout mice are defective in interferon-mediated functions. STAT 4 and STAT 6 knockout mice show defective responses to IL-12 and IL-4, respectively. Analyses of STAT 5a and STAT 5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT 3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland (5). Abnormal activity of certain STAT family members, particularly STAT 3 and STAT 5, is associated with a wide variety of human malignancies, including hematologic, breast, head and neck, and prostate cancers (1). STAT 5A and STAT 6 are selectively activated when the heart is subjected to ischemic injury, whereas activation of STAT3 and STAT 5A is involved in myocardial hypertrophy (6), (7).

General readings

Blanchard,C., (2005) Int. J. Biochem. Cell Biol. 37 (12), 2559-2573

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STAT6 antibody

Immunoperoxidase of monoclonal antibody to STAT6 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Mouse IgG2b 6C10 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

STAT6 antibody

Human Prostate; STAT6 antibody - C-terminal region (ARP31048_P050) in Human Prostate cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu, Ms, Por, Rt P
50 µg / €350.00
  AVIVA Systems Biology

STAT6 (C-term) antibody

Human placental stained with Anti-STAT6 antibody Rabbit Purified Hu, Ms, Rt IP, P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

STAT6 (C-term) antibody

Human placental stained with Anti-STAT6 antibody Rabbit Purified Hu, Ms, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

STAT6 (C-term) antibody

Human placental stained with Anti-STAT6 antibody Rabbit Purified Hu, Ms, Rt IP, P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

STAT6 antibody

Western blot analysis of extracts from HeLa cells, using STAT6 (Ab-641) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STAT6 antibody

Western Blot of Rabbit anti-STAT6 pY641 antibody. Lane 1: unstimulated Hela cell lysate. Lane 2: IL-4 stimulated Hela cell lysate. Load: 10 µg per lane. Primary antibody: STAT6 pY641 antibody at 1:1000 for overnight at 4°C. Secondary antibody: HRP goat anti-rabbit at 1:40,000 for 30 min at RT. Block: 5% Blotto, 30 min at RT. Predicted/Observed size: 94 kDa, 90 kDa. Other band(s): unspecific bands. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STAT6 antibody

Western blot analysis of STAT6 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STAT6 antibody

Western blot analysis of STAT6 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STAT6 antibody

STAT6 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

STAT6 pTyr641 (incl. pos. control) antibody

Phosphospecificity Whole cell lysates of untreated (Lane 1) and IL4-treated (Lane 2) HepG2 cells were applied to SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with STAT6 antibody clone 16E12 at 1µg/ml for 1h at 15-22°C and developed by ECL (exposure time: 3min). Mouse IgG1 16E12 Purified Hu C, E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

STAT6 (incl. pos. control) antibody

Detection of Endogenous STAT6: Whole cell lysates of serum starved tumor cells (20.000 cells per lane) were applied to SDS-PAGE and transferred to a PVDF membrane. The immunoblots was probed with mab STAT6-8C12 (0.5 µg/ ml) for 1h at RT and developed by ECL (exp. time: 30 sec).
Lane 1: A431.
Lane 2: SW480 
Lane 3: SW620
Lane 4: HT29.
Lane 5: MCF7.
Lane 6: MDA-MB231
Lane 7: T47D Mouse IgG1 8C12 Purified Can, Hu C, E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

STAT6 antibody

Immunofluorescence analysis of Hela cells using STAT6 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin Mouse IgG1 7D3 Ascites Hu, Mky, Ms, Rt E, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

STAT6 pThr645 antibody

STAT6 Rabbit Aff - Purified Hu, Ms E, IP, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

STAT6 pTyr641 antibody

Immunohistochemistry (IHC) analyzes of STAT6 pTyr641 antibody (Cat.-No.: AP01698PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

STAT6 pTyr641 antibody

Figure 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6 (phospho- Tyr641) antibody AP02349PU. Rabbit Aff - Purified Hu P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

STAT6 pTyr641 antibody

Figure 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6 (phospho- Tyr641) antibody AP02349PU. Rabbit Aff - Purified Hu P, WB
50 µl / €240.00
  Acris Antibodies GmbH

STAT6 pThr645 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6 (phospho-Thr645) antibody AP02350PU. Rabbit Aff - Purified Hu P
0.1 ml / €320.00
  Acris Antibodies GmbH

STAT6 pThr645 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6 (phospho-Thr645) antibody AP02350PU. Rabbit Aff - Purified Hu P
50 µl / €240.00
  Acris Antibodies GmbH

STAT6 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6 antibody. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

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