STIL / SIL antibody

Principal name

STIL / SIL antibody

Alternative names for STIL / SIL antibody

SCL-interrupting locus protein, TAL-1-interrupting locus protein, MCPH7, DKFZp686O0916

SwissProt ID

P92189 (Drome), Q15468 (Human), Q4V7H1 (Xenla), Q60988 (Mouse), Q8JGS1 (Danre)

Gene ID

6491 (STIL)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of STIL / SIL antibody

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STIL / SIL antibody

STIL / SIL Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

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