STIM1 / GOK antibody

Principal name

STIM1 / GOK antibody

Alternative names for STIM1 / GOK antibody

Stromal interaction molecule 1

SwissProt ID

P70302 (Mouse), P84903 (Rat), Q13586 (Human), Q58CP9 (Bovin)

Gene ID

6786 (STIM1), 361618 (Stim1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat, Sheep

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of STIM1 / GOK antibody

Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, and cell growth and proliferation. The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become of great interest. Recently, several key players of the store-operated complex have been identified.The Orai family consists of three members, Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2. Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor. The majority of STIM1 appears to be localized intracellularly at the ER membrane while low expression of STIM1 has been detected on the cell surface of several cell types. STIM1 has an amino-termil EF hand Ca2+ -binding domain facing the lumen of the ER. Upon Ca2+ store depletion, STIM1 molecules are redistributed in punctae underneath the plasma membrane and activate SOCs. Several possible interactions between STIM1 and Orai1 have been suggested. The most simple and cited is a dymic interaction between the cytosolic C-terminus of STIM1 and the cytoplasmic domain of the Orai1 channel. STIM1 is assumed to regulate the activity of all known SOCs, including tive SOCs.Consistent with their important role as calcium sensors within the ER, STIM1 proteins are ubiquitously expressed.

General readings

1. López JJ, Jardín I, Bobe R, Pariente JA, Enouf J, Salido GM, Rosado JA. STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets.
Biochem Pharmacol. 2008 Jun 1;75(11):2157-64. PMID: 18439569. In WB on Human Platelets (80kDa)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STIM1 / GOK antibody

Immunofluorescence staining of HeLa human cervix carcinoma cell line using anti-STIM1 (CDN3H4; methanol-aceton fixation; detection by Goat anti-mouse IgG1 Alexa Fluor® 598; red). Nuclei were stained with DAPI (blue). Mouse IgG1 CDN3H4 Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

Human Small Intestine, submucosal plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 5A2 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

Immunoperoxidase of monoclonal antibody to STIM1 on formalin-fixed paraffin-embedded human malignant lymphoma, diffuse large B. [antibody concentration 3ug/ml] Mouse IgG2a 5A2 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

Western Blot: Stromal interaction molecule 1 Antibody - Detection of STIM-1 in HeLa WCE. Rabbit IgG Purified Bov, Can, Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STIM1 / GOK antibody

Western blot analysis of STIM1 in mouse thymus tissue lysate with STIM1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STIM1 / GOK antibody

Western blot analysis of RBL (lanes 1 and 4), HL-60 (lanes 2 and 5), and Jurkat (lanes 3 and 6) cell lysates: 1, 2, 3. Anti-STIM1 (extracellular) antibody, (1:1000). 4, 5, 6. Anti-STIM1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

STIM1 / GOK antibody

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

STIM1 / GOK Control Peptide

STIM1 / GOK
50 µg / €160.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

STIM1 / GOK Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

STIM1 / GOK (N-term) antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Sheep IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

STIM1 / GOK (C-term) antibody

STIM1 Antibody (C-term) (Cat. #AP54072PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the STIM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

Western Blot analysis of STIM1 expression in transfected 293T cell line (H00006786-T02) by STIM1 MaxPab polyclonal antibody.

Lane 1: STIM1 transfected lysate(77.40 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

STIM1 / GOK Mouse IgG2a 6C6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

STIM1 / GOK Mouse IgG2a 1B12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

Immunofluorescence staining of HeLa cells using STIM1 monoclonal antibody, clone CDN3H4 ( Cat # MAB3602 ). Preparation by methanol-aceton fixation and detection by Goat anti-mouse IgG1 Alexa Fluor® ( red ). Nuclei were stained with DAPI ( blue ). Mouse IgG1 CDN3H4 Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

Western blot analysis of STIM1 in HeLa whole cell extract with STIM1 polyclonal antibody ( Cat# PAB12017 ). Rabbit Bov, Hu, Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

Immunohistochemistry of STIM1 in human spleen tissue with STIM1 polyclonal antibody ( Cat # PAB12992 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

STIM1 / GOK antibody

Human PANC1; WB Suggested Anti-STIM1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: PANC1 cell lysate. STIM1 is supported by BioGPS gene expression data to be expressed in PANC1.; STIM1 antibody - middle region (ARP45434_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

STIM1 / GOK antibody

Immunofluorescence: Stromal interaction molecule 1 Antibody (CDN3H4) [NB110-55300]- staining of HeLa human cervix carcinoma cell line using anti-STIM1 (CDN3H4; methanol-aceton fixation; detection by Goat anti-mouse IgG1 Alexa Fluor® 598; red). Nuclei were stained with DAPI (blue). Mouse IgG1 CDN3H4 Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

STIM1 / GOK antibody

STIM1 / GOK Rabbit Biotin Bov, Can, Hu, Ms, Rt WB
0.1 ml / €360.00
  Novus Biologicals Inc.

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