STIM1 / GOK antibody

Principal name

STIM1 / GOK antibody

Alternative names for STIM1 / GOK antibody

Stromal interaction molecule 1

SwissProt ID

P70302 (Mouse), P84903 (Rat), Q13586 (Human), Q58CP9 (Bovin)

Gene ID

6786 (STIM1), 361618 (Stim1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat, Sheep

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of STIM1 / GOK antibody

Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, and cell growth and proliferation. The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become of great interest. Recently, several key players of the store-operated complex have been identified.The Orai family consists of three members, Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2. Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor. The majority of STIM1 appears to be localized intracellularly at the ER membrane while low expression of STIM1 has been detected on the cell surface of several cell types. STIM1 has an amino-termil EF hand Ca2+ -binding domain facing the lumen of the ER. Upon Ca2+ store depletion, STIM1 molecules are redistributed in punctae underneath the plasma membrane and activate SOCs. Several possible interactions between STIM1 and Orai1 have been suggested. The most simple and cited is a dymic interaction between the cytosolic C-terminus of STIM1 and the cytoplasmic domain of the Orai1 channel. STIM1 is assumed to regulate the activity of all known SOCs, including tive SOCs.Consistent with their important role as calcium sensors within the ER, STIM1 proteins are ubiquitously expressed.

General readings

1. López JJ, Jardín I, Bobe R, Pariente JA, Enouf J, Salido GM, Rosado JA. STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets.
Biochem Pharmacol. 2008 Jun 1;75(11):2157-64. PMID: 18439569. In WB on Human Platelets (80kDa)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STIM1 / GOK antibody

Immunofluorescence staining of HeLa human cervix carcinoma cell line using anti-STIM1 (CDN3H4; methanol-aceton fixation; detection by Goat anti-mouse IgG1 Alexa Fluor® 598; red). Nuclei were stained with DAPI (blue). Mouse IgG1 CDN3H4 Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

Human Small Intestine, submucosal plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 5A2 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

  Rabbit Polyclonal Antibody against STIM-1  
Western Blot: Stromal interaction molecule 1 Antibody - Detection of STIM-1 in HeLa WCE. Rabbit IgG Purified Bov, Can, Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STIM1 / GOK antibody

  Rabbit Polyclonal STIM1 Antibody  
Western blot analysis of STIM1 in mouse thymus tissue lysate with STIM1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STIM1 / GOK antibody

  Rabbit Polyclonal Anti-STIM1 (extracellular)  
Western blot analysis of RBL (lanes 1 and 4), HL-60 (lanes 2 and 5), and Jurkat (lanes 3 and 6) cell lysates: 1, 2, 3. Anti-STIM1 (extracellular) antibody, (1:1000). 4, 5, 6. Anti-STIM1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

STIM1 / GOK antibody

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

STIM1 / GOK antibody

STIM1 / GOK Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

STIM1 / GOK (N-term) antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Sheep IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

STIM1 / GOK (C-term) antibody

STIM1 Antibody (C-term) (Cat. #AP54072PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the STIM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

STIM1 - human gene knockout kit via CRISPR

STIM1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

STIM1 - human gene knockout kit via CRISPR

STIM1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

STIM1 - human gene knockout kit via CRISPR

STIM1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

STIM1 / GOK

  Recombinant protein of human stromal interaction molecule 1 (STIM1)  
STIM1 / GOK Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

STIM1 / GOK (23-213, CaM-tag)

STIM1 / GOK Human Purified > 90 % by SDS PAGE E. coli
0.5 mg / €800.00
  Acris Antibodies GmbH

STIM1 / GOK (23-213, CaM-tag)

STIM1 / GOK Human Purified > 90 % by SDS PAGE E. coli
0.1 mg / €310.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

STIM1 overexpression lysate

STIM1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, STIM1 (Myc-DDK tagged) - Human stromal interaction molecule 1 (STIM1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, STIM1 (Myc-DDK tagged) - Human stromal interaction molecule 1 (STIM1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Stim1 (GFP-tagged ORF) - Rat stromal interaction molecule 1 (Stim1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Stim1 (GFP-tagged ORF) - Rat stromal interaction molecule 1 (Stim1), 200 uL, >10^7 TU/mL  
200 µl / €1,360.00
  OriGene Technologies, Inc.

Lenti ORF particles, Stim1 (Myc-DDK-tagged ORF) - Rat stromal interaction molecule 1 (Stim1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Stim1 (Myc-DDK-tagged ORF) - Rat stromal interaction molecule 1 (Stim1), 200 uL, >10^7 TU/mL  
200 µl / €1,223.00
  OriGene Technologies, Inc.

19 Item(s)

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